DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and Clk3

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_006243208.1	Gene:	Clk3 / 171305	RGDID:	621259	Length:	640	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	121/408 - (29%)
Similarity:	201/408 - (49%)	Gaps:	64/408 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 GPISSLKTAH------TKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS---LSAEYEVLE 196
            ||..:.|.||      |: :.|...:.:|..|||||...:.|.:  .|.|...   |...||::.
  Rat   249 GPYRTRKHAHHCHKRRTR-SCSSASSRSQQSSKRSSRSVEDDKE--GHLVCRIGDWLQERYEIVG 310

  Fly   197 FLGRGTFGQVVKC--WKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFE 258
            .||.||||:||:|  ..||.|: ||:||::|...|....::|:::|.::.:::.: :|..|...:
  Rat   311 NLGEGTFGKVVECLDHARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSD 374

  Fly   259 CFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENI 323
            .|....|.|:.||:|.:|.::|||:|.|.|.||.::|.:..|:..||..|.:..|.|.|||||||
  Rat   375 WFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENI 439

  Fly   324 MLVDPVRQPY---------------RVKVIDFGSAS--HVSKTVCNTYLQSRYYRAPEIILGLPF 371
            :.|:...:..               .::|.|||||:  |...|   |.:.:|:||.||:||.|.:
  Rat   440 LFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT---TIVATRHYRPPEVILELGW 501

  Fly   372 CEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTY 436
            .:..|:||:||::.|.:.|:.|:......:.:..:.:..|....||::...| .|:||:.    .
  Rat   502 AQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRK-QKYFYKG----G 561

  Fly   437 PFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRML 501
            ..|...:::....:.|.|..::                       .:|.:..:..:..||::|||
  Rat   562 LVWDENSSDGRYVKENCKPLKS-----------------------YMLQDSLEHVQLFDLMRRML 603

  Fly   502 TIDQERRLTPAEALNHSF 519
            ..|..:|:|.||||.|.|
  Rat   604 EFDPAQRITLAEALLHPF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	104/348 (30%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Clk3	XP_006243208.1	PHA03247	29..>162	CDD:223021
Clk3	XP_006243208.1	PKc_CLK3	292..622	CDD:271116	107/362 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810