DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Hipk3

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_034564.2	Gene:	Hipk3 / 15259	MGIID:	1314882	Length:	1192	Species:	Mus musculus

Alignment Length:	1420	Identity:	496/1420 - (34%)
Similarity:	649/1420 - (45%)	Gaps:	381/1420 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RATSFYGDQTVTATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDC 100
            ::::|...:.:.....|...||:...|:....:......|:|..|........|..|..
Mouse    16 QSSAFCSVKKLKVEPSGCVFQERTYPQIHVNGRNFGNSHPSTKGSAFQTKIPFTKPRGH------ 74

  Fly   101 GCVDSYNSSHGPPVQQDSSA-----AAGAGSVGSKAGSG----------PGPDGIG--------- 141
                |::...|..|.:|::.     ||.|...|.:|...          .||...|
Mouse    75 ----SFSLQAGAIVVKDTAGATKVLAAQAQQAGVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELE 135

  Fly   142 -------PISSLKTAHTKVATSGGHANT----QPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVL 195
                   .:..|......:.|:.|:..|    ...||::.:..:|||||||||||.|:...||||
Mouse   136 NHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSGEGDYQLVQHEVLCSMKNTYEVL 200

  Fly   196 EFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECF 260
            :||||||||||||||||||:|||||||||||||||||||||||||:|||.|||||:|||||:|||
Mouse   201 DFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECF 265

  Fly   261 QHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIML 325
            ||:|||||||||||||||||||||||||||||.|||:|:||.|||.|||.|||||||||||||||
Mouse   266 QHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIML 330

  Fly   326 VDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLG 390
            ||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||:||||||
Mouse   331 VDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLG 395

  Fly   391 WPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKS 455
            ||||||:.|:|||||||||||||.|.:||..:|:::||.|:.|.::..|||||.|||||||..||
Mouse   396 WPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKS 460

  Fly   456 KEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFT 520
            |||||||||.||||..||...|||||.|||||.|||||::|||:||.||.:.|:||.|.|||.|.
Mouse   461 KEARKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFV 525

  Fly   521 RLTHLVDYVYCNNVKASVQMMEVCR---------RGDFHTVQPAST-----LVTNFVPSSTENMT 571
            .:.||:|:.:.|:||:...:|::|:         ......::|.::     |..||....
Mouse   526 NMKHLLDFPHSNHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVASNGTAALAANFTKVG----- 585

  Fly   572 FTINNQ-LTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTM 635
             |:.:| ||:....:|..|.|| ..|..|...|            |:| ||.:  |:|||:.|.:
Mouse   586 -TLRSQALTTSAHSVVHHGIPL-QAGTAQFGCG------------DAF-HQTL--IICPPAIQGI 633

  Fly   636 PS----PTKHVV-----VGSATMQP---PLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASG 688
            |:    ||.:.:     |...|..|   |||:.|                              |
Mouse   634 PAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRP------------------------------G 668

  Fly   689 VAWPQT--GR-QMALVPSWPQ---QAPAHSLIVD-----STPLFNVEEIYP-KHHLN------LP 735
            |...||  || |..|:|:|.|   .|||.:.:..     |..|.:..::.| .:|.|      |.
Mouse   669 VLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLL 733

  Fly   736 RNDLKKESPAHHIAKGNSYRV---PRHEKKEH--QQLSPVKKRVKESSPPHQQRYQRAAHVSPQY 795
            .|.:...:| ..|:.|.::.|   |...||..  |..|   ..::.::.||      :|.:||:
Mouse   734 TNQITLSAP-QPISVGIAHVVWPQPATTKKNKLCQNRS---NSLQNTNIPH------SAFISPK- 787

  Fly   796 HAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNC 860
                                           |::|...    ..|.....|...:|.|.  ...|
Mouse   788 -------------------------------IISGKEV----EEVSCVDTQDNHTSEGE--AGTC 815

  Fly   861 NANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSP-TAVITI-SDSEDE 923
            ..      |.|.|.......|:.                  ||.|.|:||| .:|||| |||:||
Mouse   816 RE------ASVRQDSSVSDKQRQ------------------TIIIADSPSPAVSVITISSDSDDE 856

  Fly   924 GGEAGGAQVPVLKQ-RAHAQSQTSGSLLQ-------HAPSSSCSRSSAHQ-------QPHPHPQQ 973
                ..:..|.|:: :.....:...|.|.       .:|.|:.|.||:.|       :|:.....
Mouse   857 ----ETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDD 917

  Fly   974 QQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQ 1038
            :|:......|..|......|.:..|........|.:.:....|.|..:.......:||
Mouse   918 EQESGCETVDGSPTSDSSGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAVEPP------- 975

  Fly  1039 PQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIP-----TKQEPAEFYPE--YA 1096
                :..|.|.|..:.   ||.::...||....||:....  |.|     .:|:||..:|:  ..
Mouse   976 ----VGRESGLSVDEH---MANTDSTCQPLRKGQPAPGKL--HQPPALGARQQKPAAAFPQQHLN 1031

  Fly  1097 AAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSS 1161
            .:..|...|....|    :|:      ..|.:::|       |:
Mouse  1032 LSQVQHFGTGHQEW----NGN------FGHRRQQA-------YI--------------------- 1058

  Fly  1162 ISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGH 1226
                                                              |:||..:|...|||.
Mouse  1059 --------------------------------------------------PTSVTSNPFTLSHGS 1073

  Fly  1227 ------HHHQAG-TPLGGSP-----------SSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSY 1273
                  |.|.|| |.|||.|           ||.|..|.|.........:.:.||..:|.  ||.
Mouse  1074 PNHTAVHAHLAGSTHLGGQPTLLPYPSSASLSSAAPVAHLLASPCTSRPMLQHPTYNISH--PSG 1136

  Fly  1274 AY------ANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQVA 1322
            ..      .|..::..|..|.:..:.:.|.|   ::|.....|:.| ||||.:::
Mouse  1137 IVHQVPVGINPRLLPSPTIHQTQYKPIFPPH---SYIAASPAYTGF-PLSPTKLS 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	270/327 (83%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065	51/274 (19%)
Hipk3	NP_034564.2	PKc_like	196..525	CDD:304357	270/328 (82%)
		S_TKc	197..525	CDD:214567	270/327 (83%)
		Interaction with AR. /evidence=ECO:0000250	767..921		46/228 (20%)
		Interaction with FAS. /evidence=ECO:0000269\|PubMed:11034606	775..868		34/164 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..829		7/37 (19%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	832..988		40/191 (21%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	843..895		15/55 (27%)
		Interaction with UBL1. /evidence=ECO:0000250	847..857		8/13 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..943		11/53 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..1023		17/82 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850207
Domainoid	1	1.000	582	1.000	Domainoid score	I212
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	693	1.000	Inparanoid score	I681
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42611
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.780