DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Hipk1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001288233.1	Gene:	Hipk1 / 15257	MGIID:	1314873	Length:	1210	Species:	Mus musculus

Alignment Length:	1419	Identity:	528/1419 - (37%)
Similarity:	650/1419 - (45%)	Gaps:	418/1419 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PPKASDFVDYAVAGGGGSGFCSGL-----GAGLSVRATS----FYGDQTVTATTDGTRHQEQQQQ 61
            ||..|           .|.|||..     .:|..|...|    :|   |.:.|...|:.|.....
Mouse    10 PPSVS-----------SSAFCSAKKLKIEPSGWDVSGQSSNDKYY---THSKTLPATQGQASSSH 60

  Fly    62 Q-----LQQQQQQHILRQPA------TSASTSSVAAAAT-----------------------SKR 92
            |     |....|..:|..||      |:|.:|..||.||                       .||
Mouse    61 QVANFNLPAYDQGLLLPAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKR 125

  Fly    93 KRQTDCDCGCVDSYNS----SHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKV 153
            |.:.      |:|..|    ...||:...:....||.:
Mouse   126 KSEE------VESNGSVQIIEEHPPLMLQNRTVVGAAA--------------------------- 157

  Fly   154 ATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIV 218
                  ..|...:|.|||..:|||||||||:|.|::..|||||||||||||||.|||||.|.|||
Mouse   158 ------TTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIV 216

  Fly   219 AIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQ 283
            ||||||||||||||||||||||||||.|||||:||||::||||||||||||||||||||||||||
Mouse   217 AIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 281

  Fly   284 NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 348
            |||||||||||||||:||.|||:|||.||||||||||||||||||||||||||||||||||||||
Mouse   282 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 346

  Fly   349 TVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLP 413
            .||:|||||||||||||||||||||||||||||||:||||||||||||:||:|||||||||||||
Mouse   347 AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 411

  Fly   414 TEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDL 478
            .|::|::.:||::||.||.:..||.|||||.||||.||..|||||||||||||||:.|||:.|||
Mouse   412 AEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDL 476

  Fly   479 EGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEV 543
            ||..:||||.||||:|||||:|||||.::|:||.:.|||.|..::||:|:.:.::||:..|.||:
Mouse   477 EGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMSHLLDFPHSSHVKSCFQNMEI 541

  Fly   544 CRR--GDFHTV-QPASTLVTNFVPSSTENMTFTINNQL-TSQVQRLVRDGRPLAYEGLYQIYNG- 603
            |:|  ..:.|| |..|...|:..|:::.|:|.:.:||| |...|..|......|......:.|.
Mouse   542 CKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSD 606

  Fly   604 ----RSVARQYPQ-----------------------TRTDSFQHQLVSNILCPPSYQT-MPSPTK 640
                ...:..||.                       |:||.||...   |:|||::|| :.:.||
Mouse   607 VSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTF---IVCPPAFQTGLQATTK 668

  Fly   641 H-----------VVVGSATMQPPLQVP------------------PQ------QYVNVPVPVSMV 670
            |           .:|..|....|||:.                  ||      ||. ||..:|
Mouse   669 HSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYA-VPFTLS-- 730

  Fly   671 EPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLP 735
              .:..|..|..:..|...||| .|.|..|:||..||.|..:|.....|...:.|
Mouse   731 --CAAGRPALVEQTAAVLQAWP-GGTQQILLPSAWQQLPGVALHNSVQPAAVIPE---------- 782

  Fly   736 RNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHN 800
                         |.|:|           |||:..:..                      |:|
Mouse   783 -------------AMGSS-----------QQLADWRNA----------------------HSH-- 799

  Fly   801 CNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGG 865
                 |:.||        :.....|.:.|         ||.:|.|||.:....|
Mouse   800 -----GNQYS--------TIMQQPSLLTN---------HVTLATAQPLNVGVAH----------- 831

  Fly   866 AGGAVVYQQPPAHAHQQHGQQPHPQSSQ-------------------------------HPQHVK 899
                ||.||..:....:..:|..|.||:                               ..||
Mouse   832 ----VVRQQQSSSLPSKKNKQSAPVSSKSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQH-- 890

  Fly   900 QPTITIHDTPS-PTAVITI-SDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRSS 962
            || |.|.|||| |.:|||| ||:::|...........||.|::..|..:   :..:|.|..|.||
Mouse   891 QP-IIIPDTPSPPVSVITIRSDTDEEEDNKYKPNSSSLKARSNVISYVT---VNDSPDSDSSLSS 951

  Fly   963 AHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQ 1027
                  |||.            |...|.|.:........|.|.......:....||.:.|.....
Mouse   952 ------PHPT------------DTLSALRGNSGTLLEGPGRPAADGIGTRTIIVPPLKTQLGDCT 998

  Fly  1028 PQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSEC-----GYQPQ------------VPSQPSS 1075
            .......:|......:....|||          |.|     ||:.|            ..:|.||
Mouse   999 VATQASGLLSSKTKPVASVSGQS----------SGCCITPTGYRAQRGGASAVQPLNLSQNQQSS 1053

  Fly  1076 SASLPHIPTKQE----PAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAP 1136
            |||     |.||    ||....:...||..|        ||.:...|.......|     |.:||
Mouse  1054 SAS-----TSQERSSNPAPRRQQAFVAPLSQ--------APYAFQHGSPLHSTGH-----PHLAP 1100

  Fly  1137 ISYVAPSVAPPLAHSKSSSASSSSSISAATAAAA------AAAAAAAASVGPPSWGPPQVYRQPS 1195
                ||:..|...|..:.:|.:|::...:|::.|      .::..|||....||....||
Mouse  1101 ----APAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQV----- 1156

  Fly  1196 QPPPGSVGLPGSTQPPPS-----SVAPHPHHHSHGHHHHQAGTP--LGGSPSST 1242
               |.|||        ||     ||||       ..:.||..|.  :|.|..||
Mouse  1157 ---PVSVG--------PSLLTSASVAP-------AQYQHQFATQSYIGSSRGST 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	274/327 (84%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065	47/180 (26%)
Hipk1	NP_001288233.1	STKc_HIPK1	174..528	CDD:271130	288/353 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856		6/20 (30%)
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847		0/2 (0%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093		64/254 (25%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998		36/128 (28%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..981		13/63 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069		11/27 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1104		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	582	1.000	Domainoid score	I212
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	693	1.000	Inparanoid score	I681
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38932at33208
OrthoFinder	1	1.000	-	-		FOG0002956
OrthoInspector	1	1.000	-	-		otm42611
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860