DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Dyrk1b

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001258299.1	Gene:	Dyrk1b / 13549	MGIID:	1330302	Length:	689	Species:	Mus musculus

Alignment Length:	718	Identity:	200/718 - (27%)
Similarity:	291/718 - (40%)	Gaps:	199/718 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 HGPPVQQDSSA-----AAGAGSVGS---KAGSG----PG-------------PDGIGPISSL--K 147
            |..|..:..||     .:|.||.|:   ||..|    ||             |.|.||.|..  .
Mouse    12 HRAPAPRGPSAIPDPGLSGGGSRGAGCEKAPPGRAPAPGLTPLRPSEPTMAVPPGHGPFSGFPGP 76

  Fly   148 TAHTKV------------------------------------------ATSGGHANTQPPSKRSS 170
            ..||:|                                          |.....|...||...|:
Mouse    77 QEHTQVLPDVRLLPRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSST 141

  Fly   171 S--------GADGDYQLVQHEVLYSLSAE-----YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKI 222
            .        |.|.|    .|:.:.. |.|     ||:...:|:|:||||||.:...|.|:|||||
Mouse   142 KKEKKVLNHGYDDD----NHDYIVR-SGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKI 201

  Fly   223 LKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKF 286
            :||..::..|.|||:.:|..::|.:.: ::..|.....|..:||.|||||:|..||||.|:...|
Mouse   202 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF 266

  Fly   287 SPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT 349
            ..:.|...|.:.:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.
Mouse   267 RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQR 329

  Fly   350 VCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPT 414
            :.. |:|||:||:||::||.|:..|||||||||::.|:..|.||:.||:|.||:..|.:..|:|.
Mouse   330 IYQ-YIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPP 393

  Fly   415 EHMLNSASKTSKFFYRDVDSTYP--FWRLKTTEE----HEAETNTKSKEARKYIFNCLDDIGQVN 473
            ..||..|.|..|:|.|     .|  .|.|:.|:|    ::.....:.:|.             :.
Mouse   394 APMLEQAPKARKYFER-----LPGGGWTLRRTKELRKDYQGPGTRRLQEV-------------LG 440

  Fly   474 VPTDLEGGQLLAE----KTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYV----- 529
            |.|...||:...|    ..|...|.||:.|||..:...|::|..||.|.|.|.|  .|..
Mouse   441 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT--ADEATNTGP 503

  Fly   530 YCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVP------SSTENMTFTINNQLTSQVQRLVRD 588
            ..::...|...::.|         |:|:..::...      ||.:|..:..:|:........:.|
Mouse   504 AGSSASTSPAPLDTC---------PSSSTASSISSSGGSSGSSNDNRAYRYSNRYCGGPGPPITD 559

  Fly   589 ----------GRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVV 643
                      .:||      :.:.|..|..:         .||      .|.|..|:|
Mouse   560 CEMNSPQVLPSQPL------RPWAGGDVPHK---------THQ------APISASTLP------- 596

  Fly   644 VGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQA 708
             |:....|||   |:.....|.|.|...|......|:.:....|              |..|..|
Mouse   597 -GTGAQLPPL---PRCLGRPPSPTSPPPPELMDVSLVGSPPDCS--------------PPPPAPA 643

  Fly   709 PAH 711
            |.|
Mouse   644 PQH 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	129/340 (38%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Dyrk1b	NP_001258299.1	PKc_DYRK1	157..496	CDD:271128	135/362 (37%)
Dyrk1b	NP_001258299.1	S_TKc	171..491	CDD:214567	129/340 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840