DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and CLK1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001155879.1	Gene:	CLK1 / 1195	HGNCID:	2068	Length:	526	Species:	Homo sapiens

Alignment Length:	451	Identity:	133/451 - (29%)
Similarity:	219/451 - (48%)	Gaps:	77/451 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 QTDCDCGCVDSYNS-SHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGG 158
            :.|...||...:.. .|....|..||.::|      ::|.          ||.|:.| ::..|..
Human   119 RNDYTQGCEPGHRQRDHESRYQNHSSKSSG------RSGR----------SSYKSKH-RIHHSTS 166

  Fly   159 HANTQPPS---KRSSSGADGDYQLVQHEVLYS---LSAEYEVLEFLGRGTFGQVVKC--WKRGTS 215
            |..:...|   ||:.|..|.:   ..|.:..|   |||.||:::.||.|.||:||:|  .|.| .
Human   167 HRRSHGKSHRRKRTRSVEDDE---EGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAG-G 227

  Fly   216 EIVAIKILKNHPSYARQGQIEVSILSRLSQENADE-FNFVRAFECFQHKNHTCLVFEMLEQNLYD 279
            ..||:||:||...|....:.|:.:|..|:..:.:. |..|:..|.|:|..|.|:|||:|..:.||
Human   228 RHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYD 292

  Fly   280 FLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVD---------PVRQPYR- 334
            |:|:|.|.|..|.:||.:..|:..::..|....|.|.|||||||:.|.         .:::..|
Human   293 FIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERT 357

  Fly   335 -----VKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLY 394
                 :||:|||||::..:. .:|.:.:|:|||||:||.|.:.:..|:||:||::.|.:||:.::
Human   358 LINPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVF 421

  Fly   395 PGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRD-VDSTYPFWRLKTTEEHEAETNTKSKEA 458
            |.....:.:..:.:..|...:||:....| .|:|:.| :|     |     :||.:        |
Human   422 PTHDSKEHLAMMERILGPLPKHMIQKTRK-RKYFHHDRLD-----W-----DEHSS--------A 467

  Fly   459 RKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSF 519
            .:|:......:.:.          :|::..:.....||:::||..|..:|:|..|||.|.|
Human   468 GRYVSRRCKPLKEF----------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	108/347 (31%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
CLK1	NP_001155879.1	PKc_CLK1_4	190..519	CDD:271115	113/360 (31%)
CLK1	NP_001155879.1	S_TKc	203..519	CDD:214567	108/347 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810