DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and Dyrk4

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_011239406.1	Gene:	Dyrk4 / 101320	MGIID:	1330292	Length:	685	Species:	Mus musculus

Alignment Length:	357	Identity:	135/357 - (37%)
Similarity:	190/357 - (53%)	Gaps:	41/357 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 SKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYA 230
            ||.|.....|.|..|.|:   .::..|||||.:|:|:||||.||.....:|:||:||::|...:.
Mouse   249 SKTSFDDEHGSYMKVLHD---HIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFH 310

  Fly   231 RQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYI 294
            .|..:|:.||..|.:::.| ..|.|...:.|..:||.|:.||:|..|||:.:|.|.|....|..:
Mouse   311 HQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIV 375

  Fly   295 RPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRY 359
            |.....:|..|..|....:||.|||||||:|..  |....||||||||:.:..:.| .||:|||:
Mouse   376 RRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQ--RGQVTVKVIDFGSSCYEHQKV-YTYIQSRF 437

  Fly   360 YRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKT 424
            ||:||:|||.|:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|||..|...:||:.
Mouse   438 YRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRR 502

  Fly   425 SKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVP--TDLEGGQLLAEK 487
            ..||                         .||...|.|.|   :.|....|  .||    .:..|
Mouse   503 QVFF-------------------------DSKGLPKNINN---NRGGKRYPDSKDL----TMVVK 535

  Fly   488 TDRREFIDLLKRMLTIDQERRLTPAEALNHSF 519
            |....|:|.|:|.|..:...|:||.:||.|::
Mouse   536 TYDSSFLDFLRRCLVWEPSLRMTPEQALKHAW 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	128/331 (39%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Dyrk4	XP_011239406.1	PKc_DYRK4	228..568	CDD:271127	135/357 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840