DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and HIPK3

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_005725.3	Gene:	HIPK3 / 10114	HGNCID:	4915	Length:	1215	Species:	Homo sapiens

Alignment Length:	1277	Identity:	473/1277 - (37%)
Similarity:	607/1277 - (47%)	Gaps:	341/1277 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 ATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIV 218
            ||:|        ||::.:..:|||||||||||.|:...||||:||||||||||||||||||:|||
Human   167 ATTG--------SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIV 223

  Fly   219 AIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQ 283
            ||||||||||||||||||||||:|||.|||||:|||||:|||||:||||||||||||||||||||
Human   224 AIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ 288

  Fly   284 NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 348
            |||||||||.|||||:||.|||.|||.||||||||||||||||||||||||||||||||||||||
Human   289 NKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 353

  Fly   349 TVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLP 413
            |||:|||||||||||||||||||||||||||||||:||||||||||||:.|:|||||||||||||
Human   354 TVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLP 418

  Fly   414 TEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDL 478
            .|.:||..:|:::||.::.|.::..|||||.|||||||..|||||||||||.|||:..||...||
Human   419 GEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDL 483

  Fly   479 EGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEV 543
            ||..|||||.|||||:.|||:||.||.:.|:||||.|||.|..:.||:|:.:.|:||:...:|::
Human   484 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDI 548

  Fly   544 CRR------GDFHTVQPASTLVTNFVPSSTENMTF------TINNQ-LTSQVQRLVRDGRPLAYE 595
            |:.      .:.|.   .::|:.....|||..:|.      |:.:| ||:....:|..|.|| ..
Human   549 CKSHLNSCDTNNHN---KTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPL-QA 609

  Fly   596 GLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPS----PTKHVV-----VGSATMQP 651
            |..|...|            |:||..|   |:|||:.|.:|:    ||.:.:     |...|..|
Human   610 GTAQFGCG------------DAFQQTL---IICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAP 659

  Fly   652 ---PLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGV---AWPQTGR-QMALVPSWPQQAP 709
               |||:.|                              ||   .|  :|| |..|||:|.|..|
Human   660 AVQPLQIRP------------------------------GVLSQTW--SGRTQQMLVPAWQQVTP 692

  Fly   710 AHSLIVDSTPLFNVEEIYPKHHLN---------------LPR----NDLKKESPAHHIAKGNSYR 755
                :..:|.....|.:...|.|.               :|:    |.:...:| ..::.|.::.
Human   693 ----LAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAP-QPVSVGIAHV 752

  Fly   756 V---PRHEKKEHQ-QLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSV 816
            |   |...||..| |...:..::.|..|..::.                    |...:|.|..:.
Human   753 VWPQPATTKKNKQCQNRGILVKLMEWEPGREEI--------------------NAFSWSNSLQNT 797

  Fly   817 -VASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAH 880
             :..||..|..|:||...    ..|.....|...:|.|.  ..||....      :.|...:...
Human   798 NIPHSAFISPKIINGKDV----EEVSCIETQDNQNSEGE--ARNCCETS------IRQDSDSSVS 850

  Fly   881 QQHGQQPHPQSSQHPQHVKQPTITIHDTPSP-TAVITISDSEDEGGEAGGAQVPVLKQRAHAQSQ 944
            .:..|                ||.|.|:||| .:|||||...||         ....|| |:..:
Human   851 DKQRQ----------------TIIIADSPSPAVSVITISSDTDE---------EETSQR-HSLRE 889

  Fly   945 TSGSLLQHA---------------PSSSCSRSSAHQ-------QPHPHPQQQQQQQINYGDHDPE 987
            ..|||...|               |.|:.|.||:.|       :|:....::|:...:..|..|.
Human   890 CKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPT 954

  Fly   988 DARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQK 1052
            .....|.:..|.:......|.:.:....|        ..:.:|....|:   .|.::.|.|.:..
Human   955 SDSSGHDSPFAESTFVEDTHENTELVSSA--------DTETKPAVCSVV---VPPVELENGLNAD 1008

  Fly  1053 KRILAMAQSECGYQPQVP--------SQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRSS 1109
            :.   ||.::...||.:.        :|||:      :.|:|:      :..:|..||
Human  1009 EH---MANTDSICQPLIKGRSAPGRLNQPSA------VGTRQQ------KLTSAFQQQ------- 1051

  Fly  1110 WAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAA 1174
                                                    |...|......|
Human  1052 ----------------------------------------HLNFSQVQHFGS------------- 1063

  Fly  1175 AAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGH------HHHQAG- 1232
                  |...|.             |:.|........|:||..:|...|||.      |.|.||
Human  1064 ------GHQEWN-------------GNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGN 1109

  Fly  1233 TPLGGSP-----------SSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAY------ANRAV 1280
            |.|||.|           ||.|..|.|.........:.:.||..:|.  ||...      .|..:
Human  1110 THLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISH--PSGIVHQVPVGLNPRL 1172

  Fly  1281 VAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQVA 1322
            :..|..|.:..:.:.|.|   ::|.....|:.| ||||.:::
Human  1173 LPSPTIHQTQYKPIFPPH---SYIAASPAYTGF-PLSPTKLS 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	269/327 (82%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065	50/267 (19%)
HIPK3	NP_005725.3	STKc_HIPK3	196..525	CDD:271131	269/328 (82%)
		S_TKc	197..525	CDD:214567	269/327 (82%)
		Interaction with AR. /evidence=ECO:0000250	767..944		49/234 (21%)
		Interaction with FAS. /evidence=ECO:0000250	796..891		31/132 (23%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	855..1011		41/195 (21%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	866..918		16/61 (26%)
		Interaction with UBL1. /evidence=ECO:0000305	870..880		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..987		14/82 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159838
Domainoid	1	1.000	581	1.000	Domainoid score	I211
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	696	1.000	Inparanoid score	I683
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38932at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40540
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790