DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and dyrk2

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_002937581.2	Gene:	dyrk2 / 100485120	XenbaseID:	XB-GENE-854514	Length:	625	Species:	Xenopus tropicalis

Alignment Length:	517	Identity:	160/517 - (30%)
Similarity:	240/517 - (46%)	Gaps:	88/517 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TATTDGTRH------------QEQQQQQLQQQQQQH--ILRQPATSASTSSVAAAATSKRKRQTD 97
            |.||.|.:|            |.|.||..::...:.  :..||....:.........|:|:
Frog    90 THTTGGNKHTMNEHLHVTSHGQIQVQQLFEENSNKRTVLTTQPNGLTTVGKSTLPVVSERQ---- 150

  Fly    98 CDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANT 162
                 ::|.:...|    ..||..:..|....|:.|      :.|..::|....|:.....|...
Frog   151 -----LESTHRRQG----SSSSLKSAEGITKLKSSS------LTPEQAMKQYMQKLTAFEHHEIF 200

  Fly   163 QPP---------SKR-------SSSGAD---GDYQLVQHE-VLYSLSAEYEVLEFLGRGTFGQVV 207
            ..|         .||       ::.|.|   |.|..|.|: |.|    .||||:.:|:|:|||||
Frog   201 NYPEIYFLGPNAKKRQGVIGGPNNGGYDDDQGSYVQVPHDHVAY----RYEVLKVIGKGSFGQVV 261

  Fly   208 KCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFE 271
            |.:.....:.||:|:::|...:.||...|:.||..|.:::.| ..|.:...|.|..:||.|:.||
Frog   262 KAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICMTFE 326

  Fly   272 MLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVK 336
            :|..|||:.:|:|||....|..:|.....:|..|..|.:..:||.|||||||:|....|.  .:|
Frog   327 LLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRS--GIK 389

  Fly   337 VIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFD 401
            ||||||:.:..:.| .||:|||:|||||:|||..:...||||||||::|||..|:||.||..|.|
Frog   390 VIDFGSSCYEHQRV-YTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGD 453

  Fly   402 QIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCL 466
            |:..:.:..|:|::.:|: |||..|.|:.  ...||.:...|:....:......:..|
Frog   454 QLACMIELLGMPSQKLLD-ASKRGKNFFS--SKGYPRYCTVTSLPDGSVVLNGGRSRR------- 508

  Fly   467 DDIGQVNVP-------TDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTR 521
               |::..|       |.|:|       .|...|:|.|.:.|..|...|:||::||.|.:.|
Frog   509 ---GKLRGPPGSRDWVTALKG-------CDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	124/335 (37%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
dyrk2	XP_002937581.2	PKc_DYRK2_3	180..559	CDD:271126	139/405 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940