DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and dyrk3

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001108400.1	Gene:	dyrk3 / 100141364	ZFINID:	ZDB-GENE-080219-31	Length:	581	Species:	Danio rerio

Alignment Length:	467	Identity:	153/467 - (32%)
Similarity:	212/467 - (45%)	Gaps:	87/467 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 DSYN------SSHG---------PP-------VQQDSSAAAGAGSVG-SKAGSGPGPDG------ 139
            ||||      |.|.         ||       |..:||..:...|.. :|.||...|:.
Zfish    78 DSYNRKLNGVSQHNGTSQVPAKPPPAISKERSVDSNSSVKSSESSTKVTKLGSPMTPEQALKQHR 142

  Fly   140 -------------------IGPISSLKTAHTKVATSGGHANTQPPSKRSSSGAD---GDYQLVQH 182
                               :||     .|..:.|.:||..|         ||.|   |.|..|.|
Zfish   143 QQMTTLEQQEIHNYSEIYFLGP-----NAKKRQAVAGGTNN---------SGYDDDQGGYIHVPH 193

  Fly   183 EVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRL-SQE 246
            :   .|:..||.|:.:|:|:||||.|.:.....:.||:||::|...:.||...|:.||..| .|:
Zfish   194 D---HLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQD 255

  Fly   247 NADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQL 311
            .....|.|...|.|..:||.|:.||:|..|||:.:|:|||....|..:|.....:|..|..|.:.
Zfish   256 KTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRH 320

  Fly   312 GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAID 376
            .:||.|||||||:|....|.  .:|||||||:....:.| .||:|||:|||||:|||..:...||
Zfish   321 KIIHCDLKPENILLKQQGRS--GIKVIDFGSSCFDHQRV-YTYIQSRFYRAPEVILGSRYGMPID 382

  Fly   377 MWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRL 441
            |||.||::|||..|:||:||..|.||:..:.:..|:|...:|..|.:...|.   ....:|.:..
Zfish   383 MWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFI---SSKGHPRYCT 444

  Fly   442 KTTEEHEAETNTKSKEARKYIFNCLDDIGQV-NVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQ 505
            .:|..:.......|:..|          |:: ..|...|.|..|....| ..|||.||:.|..|.
Zfish   445 VSTLSNGTIVLNGSRSRR----------GKMRGAPGSKEWGTALKGCED-ATFIDFLKKCLDWDP 498

  Fly   506 ERRLTPAEALNH 517
            ..|:||.:||.|
Zfish   499 STRMTPVQALRH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	122/328 (37%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
dyrk3	NP_001108400.1	PKc_DYRK2_3	134..513	CDD:271126	138/411 (34%)
dyrk3	NP_001108400.1	S_TKc	200..513	CDD:214567	122/328 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810