DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and dyrk1aa

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001074158.1	Gene:	dyrk1aa / 100005019	ZFINID:	ZDB-GENE-050302-29	Length:	737	Species:	Danio rerio

Alignment Length:	680	Identity:	199/680 - (29%)
Similarity:	289/680 - (42%)	Gaps:	172/680 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVR 255
            ||:...:|:|:||||||.:.|...|.|||||:||..::..|.||||.:|..:::.:.: ::..|.
Zfish   164 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVH 228

  Fly   256 AFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKL--KQLGLIHADL 318
            ....|..:||.|||||||..||||.|:...|..:.|...|...:|:.||||.|  .:|.:||.||
Zfish   229 LKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDL 293

  Fly   319 KPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCV 383
            |||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::||:|:..|||||||||:
Zfish   294 KPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLGMPYDLAIDMWSLGCI 355

  Fly   384 VAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHE 448
            :.|:..|.||:.|::|.||:..|.:..|:|..|:|..|.|..|||.:..||   .|..|.|::.:
Zfish   356 LVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARKFFEKMPDS---MWCAKKTKDGK 417

  Fly   449 AETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEK----TDRREFIDLLKRMLTIDQERRL 509
               ..|...:||     |..|  :.|.....||:...|.    .|..:|.||:.|||..|.:.|:
Zfish   418 ---RYKPAGSRK-----LHSI--LGVEAGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRI 472

  Fly   510 TPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTI 574
            .|..||.|||.:.|  .|  ...|..:||.......       |..|:..|:...||:...:.|.
Zfish   473 QPYYALQHSFFKKT--AD--EGTNTSSSVSTSPALE-------QSQSSGTTSSTSSSSGGSSGTS 526

  Fly   575 NNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQ----------LVSNILCP 629
            .                          :||  ||..|   |...:|.          :..:.|||
Zfish   527 T--------------------------SGR--ARSDP---THQHRHSGGGHFSAAVAMDCHNLCP 560

  Fly   630 PSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQT 694
            .:.|..                   ||...:|.           .|.:       ||||...|..
Zfish   561 QARQAF-------------------VPALGWVG-----------DGLQ-------QASGETHPVQ 588

  Fly   695 GRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRH 759
            .....:.|..|:....|                 :||              ||         ..|
Zfish   589 ETTFHVPPHQPKALHPH-----------------QHH--------------HH---------HHH 613

  Fly   760 EKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASS 824
            ....|.| .|.:.|.:..||.|....|.:..|:   |.|.:.             :.::|||:||
Zfish   614 HPPPHGQ-GPARPRPRLYSPSHSASTQDSMEVT---HGHLSM-------------TSLSSSASSS 661

  Fly   825 SNIVNGSSSSSHHHHVPVAHAQPYSSSSGH 854
            |   ..|||:.:||:...:...|:....||
Zfish   662 S---TSSSSTGNHHYAYQSRPLPHGLGFGH 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	134/334 (40%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
dyrk1aa	NP_001074158.1	PKc_DYRK1	151..488	CDD:271128	136/341 (40%)
dyrk1aa	NP_001074158.1	S_TKc	164..483	CDD:214567	134/334 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840