DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cypl and Ppid

DIOPT Version :9

Sequence 1:NP_523874.1 Gene:Cypl / 38069 FlyBaseID:FBgn0035141 Length:176 Species:Drosophila melanogaster
Sequence 2:NP_080628.1 Gene:Ppid / 67738 MGIID:1914988 Length:370 Species:Mus musculus


Alignment Length:147 Identity:67/147 - (45%)
Similarity:86/147 - (58%) Gaps:16/147 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 MGEITVELYWKHAPNTCRNFAEL--------SRRG---YYNNVVFHRIIRDFMIQGGD-PTGTGR 81
            :|.|.:||:....|.|..||..|        |..|   ::....|||||:.||||||| ....|.
Mouse    29 VGRIVLELFADIVPKTAENFRALCTGEKGTGSTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGT 93

  Fly    82 GGASIYGSEFADE-LHGDLRHTGAGILSMANSGPDTNGSQFFITLAPTQWLDGKHTIFGRVYTGM 145
            ||.||||.:|.|| .|  .:|...|:|||||:||:|||||||||..||..|||||.:||:|..|:
Mouse    94 GGESIYGEKFEDENFH--YKHDREGLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVIKGL 156

  Fly   146 EVVKRIGMVETDKNDRP 162
            .|.:.:..||.: .::|
Mouse   157 GVARTLENVEVN-GEKP 172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CyplNP_523874.1 cyclophilin 24..170 CDD:294131 67/147 (46%)
PpidNP_080628.1 cyclophilin_ABH_like 16..182 CDD:238907 67/147 (46%)
Chaperone activity. /evidence=ECO:0000250 185..215
Interaction with HSP90AB1. /evidence=ECO:0000250 214..370
TPR_11 223..304 CDD:290150
TPR repeat 223..251 CDD:276809
TPR repeat 272..302 CDD:276809
TPR_11 277..338 CDD:290150
TPR 277..306 CDD:197478
TPR repeat 307..335 CDD:276809
TPR_1 308..340 CDD:278916
TPR repeat 341..364 CDD:276809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0652
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000032
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.900

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