DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cypl and PPWD1

DIOPT Version :9

Sequence 1:	NP_523874.1	Gene:	Cypl / 38069	FlyBaseID:	FBgn0035141	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	NP_056157.1	Gene:	PPWD1 / 23398	HGNCID:	28954	Length:	646	Species:	Homo sapiens

Alignment Length:	151	Identity:	86/151 - (56%)
Similarity:	103/151 - (68%)	Gaps:	1/151 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LETSMGEITVELYWKHAPNTCRNFAELSRRGYYNNVVFHRIIRDFMIQGGDPTGTGRGGASIYGS 89
            :.||||:|..:|:....|.|..||...||.||||...|||||:.||||.|||||||.||.||:|.
Human   496 IHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGG 560

  Fly    90 EFADELHGDLRHTGAGILSMANSGPDTNGSQFFITLAPTQWLDGKHTIFGRVYTGMEVVKRIGMV 154
            ||.||.|..|||.....|||||:|.:|||||||||:.||.|||.|||:||||..|||||:||..|
Human   561 EFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNV 625

  Fly   155 ETD-KNDRPVDPLRIIKAKVE 174
            :.: |.|:|.:.:.||...|:
Human   626 KVNPKTDKPYEDVSIINITVK 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cypl	NP_523874.1	cyclophilin	24..170	CDD:294131	84/145 (58%)
PPWD1	NP_056157.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		WD 1	80..118
		WD40	89..>318	CDD:421866
		WD 2	124..162
		WD40 repeat	136..177	CDD:293791
		WD 3	168..208
		WD40 repeat	191..219	CDD:293791
		WD 4	213..252
		WD40 repeat	226..277	CDD:293791
		WD 5	271..309
		WD40 repeat	283..326	CDD:293791
		WD 6	345..386
		WD 7	401..453
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..490
		cyclophilin_WD40	495..643	CDD:238908	85/146 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920