Protein Alignment Cypl and Ranbp2

DIOPT Version :10

• Sequence 1: NP_523874.1
• Gene: Cypl / 38069
• FlyBaseID: FBgn0035141
• Length: 176
• Species: Drosophila melanogaster
• Sequence 2: NP_035370.2
• Gene: Ranbp2 / 19386
• MGIID: 894323
• Length: 3053
• Species: Mus musculus
• Alignment Length: 127
• Identity: 63/127 - (49%)
• Similarity: 83/127 - (65%)
• Gaps: 5/127 - (3%)

  Fly    29 MGEITVELYWKHAPNTCRNFAEL--SRRGY-YNNVVFHRIIRDFMIQGGDPTG-TGRGGASIYGS 89
            :|.|.:||:....|.|..||..|  ..:|: :.|.:|||::.||:.||||.|. .|.||.||||.
Mouse  2906 LGRIIMELFSNIVPQTAENFRALCTGEKGFGFKNSIFHRVVPDFICQGGDITKYNGTGGQSIYGD 2970

  Fly    90 EFADELHGDLRHTGAGILSMANSGPDTNGSQFFITLAPTQWLDGKHTIFGRVYTGMEVVKRI 151
            :|.|| :.||:|||.|:|||||.|.:||.|||||||...:.||.||.:||.|..||:.|::|
Mouse  2971 KFDDE-NFDLKHTGPGLLSMANYGQNTNSSQFFITLKKAEHLDFKHVVFGFVKDGMDTVRKI 3031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cypl	NP_523874.1	cyclophilin	24..170	CDD:469651	63/127 (50%)
Ranbp2	NP_035370.2	TPR 1	26..59
		LapB	<33..221	CDD:442196
		TPR repeat	59..89	CDD:276809
		TPR 2	60..93
		TPR 3	94..128
		TPR 4	165..201
		TPR 5	288..319
		TPR 6	583..616
		TPR 7	648..681
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	773..802
		20 X 2 AA repeats of F-G. /evidence=ECO:0000305	1000..3035		63/127 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1171
		RanBD1_RanBP2-like	1180..1296	CDD:270203
		zf-RanBP	1345..1374	CDD:395516
		RanBP2-type Zn finger	1350..1369	CDD:275375
		zf-RanBP	1410..1438	CDD:395516
		RanBP2-type Zn finger	1414..1433	CDD:275375
		zf-RanBP	1469..1498	CDD:395516
		RanBP2-type Zn finger	1473..1492	CDD:275375
		zf-RanBP	1499..1524	CDD:395516
		RanBP2-type Zn finger	1502..1521	CDD:275375
		zf-RanBP	1558..1587	CDD:395516
		RanBP2-type Zn finger	1562..1581	CDD:275375
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1587..1609
		zf-RanBP	1617..1645	CDD:395516
		RanBP2-type Zn finger	1621..1640	CDD:275375
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1648..1675
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1744..1772
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1819..1846
		RanBD2_RanBP2-like	1864..1980	CDD:269998
		Interaction with BICD2. /evidence=ECO:0000250|UniProtKB:P49792	1984..2124
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2030..2060
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2111..2144
		RanBD3_RanBP2-like	2161..2277	CDD:270204
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2316..2348
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2394..2430
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2443..2463
		IR1-M	2468..2530	CDD:463488
		Interaction with sumoylated RANGAP1. /evidence=ECO:0000250	2468..2472
		2 X 50 AA approximate repeats	2470..2596
		Required for E3 SUMO-ligase activity. /evidence=ECO:0000250	2470..2545
		Interaction with UBE2I. /evidence=ECO:0000250	2470..2522
		Interaction with SUMO1. /evidence=ECO:0000250	2523..2596
		IR1-M	2544..2604	CDD:463488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2598..2666
		RanBD4_RanBP2-like	2754..2870	CDD:269999
		cyclophilin_ABH_like	2893..3051	CDD:238907	63/127 (50%)