DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cypl and PPIE

DIOPT Version :9

Sequence 1:	NP_523874.1	Gene:	Cypl / 38069	FlyBaseID:	FBgn0035141	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	NP_001181936.1	Gene:	PPIE / 10450	HGNCID:	9258	Length:	314	Species:	Homo sapiens

Alignment Length:	133	Identity:	66/133 - (49%)
Similarity:	83/133 - (62%)	Gaps:	5/133 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GEITVELYWKHAPNTCRNFAEL--SRRGY-YNNVVFHRIIRDFMIQGGDPTG-TGRGGASIYGSE 90
            |.|.:.|.....|.|..||..|  ..:|: :....|||||..||.||||.|. .|.||.||||.:
Human   154 GRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKK 218

  Fly    91 FADELHGDLRHTGAGILSMANSGPDTNGSQFFITLAPTQWLDGKHTIFGRVYTGMEVVKRIGMVE 155
            |.|| :..|:|||.|:||||||||:|||||||:|...|.||||||.:||.|..|::|:::|.:..
Human   219 FDDE-NFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLRQIEVAP 282

  Fly   156 TDK 158
            ..|
Human   283 DTK 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cypl	NP_523874.1	cyclophilin	24..170	CDD:294131	66/133 (50%)
PPIE	NP_001181936.1	RRM	<5..>84	CDD:223796
		RRM_PPIE	8..80	CDD:240793
		cyclophilin_ABH_like	140..279	CDD:238907	64/125 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900