DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment klar and anc-1

DIOPT Version :9

Sequence 1:NP_001261211.1 Gene:klar / 38067 FlyBaseID:FBgn0001316 Length:2272 Species:Drosophila melanogaster
Sequence 2:NP_491353.2 Gene:anc-1 / 172034 WormBaseID:WBGene00000140 Length:8545 Species:Caenorhabditis elegans


Alignment Length:2875 Identity:532/2875 - (18%)
Similarity:903/2875 - (31%) Gaps:1030/2875 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 NSEKEVA---LISNQE-----TEKAAMIS---GGKEGSVRDLESPNETA-----TTQKIEHTTK- 64
            |:||.||   |||:.:     .||...:.   ..|:.::....:.||.|     .:|:::...: 
 Worm  6080 NNEKAVAPSSLISHDDLVVGLPEKVFQLQHAIDDKKQALNKAAAVNEIAPKLQLVSQQLQSVPQE 6144

  Fly    65 -PLKLD-----------------GIFA-MPATPPNRAGLTTKSA-SSSRSSSLKKQRRGSRGS-- 107
             |..||                 .:.| :|...|....|..||. ..||...|.||...:.|.  
 Worm  6145 VPASLDEQKQLLEDVENQKHNLENLLANLPENDPTADELRQKSQWDLSRLKDLLKQLGSAVGDKL 6209

  Fly   108 ---ANLNVA--GTGDGAPKRSAPGGGQLNYGTNSVGNDLMKQSQSMTSL----------KASNEE 157
               |..|.|  ...|.....:...||..|...:.:.:||.|:.:::..|          :..::|
 Worm  6210 AALAAFNAARKNAEDALLDITREDGGDDNKSPDELIDDLAKKEETVAKLLDTVSGVKPDELDDKE 6274

  Fly   158 QQESRDVIQAKLHLERPYNSLKKNSHSNKMHRYSWGSGNSQCSSTSLHSSATLGLGS-----SGK 217
            :.|..|:: |:|....   .:.||..:....     :..::....|||.|....:..     ...
 Worm  6275 RAEYNDLL-ARLATAA---DVLKNKRAELEQ-----AVKAKADEKSLHDSVDRIVSRLVPLVRES 6330

  Fly   218 DDL---WAAIQTNYNYIMDTNLLDTCKEARCEIEGAATVLEK--SSECSFKMLDET--------- 268
            |:|   ..|:.|.|        ....:|.:.|:|.|..|:..  ||:...:.|::.         
 Worm  6331 DELRHNAEAVPTQY--------APKAEELKKEVEAAKAVIANAPSSDAHVQQLEQAVATAETLIP 6387

  Fly   269 --------------------------QRP------------EGLCEDPKELR---RWLREMENKL 292
                                      |:|            |...:|.:.||   :.|.:::||:
 Worm  6388 DLEERARLWNEFLAARNDIDALIEQLQQPLDAVLAQPKRSAEEAAQDVENLRNNSQQLSDLDNKI 6452

  Fly   293 ESSPTITEL-----------TLFG-NAELQRHLAVHSVLYHEIASHARVVSSCIRAAEKEQQLQQ 345
            .:...|:||           ..|. :||..||      .|.::.:..        |||.|.:...
 Worm  6453 ANLQRISELLDPLESAYADVRFFDVDAEQTRH------QYDDVLNDV--------AAELEDETLL 6503

  Fly   346 QQQLSSQQPASLTSNCSSESTSESATKSSSLSSGF-ASDPVTTPIGTAAAAPPSSSTHPSKKGEG 409
            :|                 |.|:.|.:...:|... ::||..:.:.|.|     .|..|:.|.: 
 Worm  6504 KQ-----------------SASQVANEIDDISKMIDSTDPERSILDTIA-----KSDIPALKAQ- 6545

  Fly   410 NLERLRDRY--------HL-----------------------------------------LYLKA 425
             :.|::||.        |:                                         |.:..
 Worm  6546 -INRIKDRIVNADASRKHVTTDPKIAEDLDNKLAKLQTELDDAIKTSDEHDKEQLILSLKLNISQ 6609

  Fly   426 FEL----QLCLDNLLRKRSSAANGLDDDEDE------EEDTEDDSFGYEGEATEDD----LNEVN 476
            ||.    ||..|:|........|.|..:|.|      :|..|....|.|..:...|    |.:..
 Worm  6610 FEQIPLDQLKSDDLKTAEKEITNSLKPEEAEPLLAKIQELREAKRVGDEARSAAHDQIVALEKEA 6674

  Fly   477 SDLDLENS-----ESKSATPAELI-------------LQRCQIA-------------ATQIVCGL 510
            .|:..:.|     :.|..:|.|:|             :.:.:.|             |.|:|..|
 Worm  6675 EDVTAKESAKKKKKDKKKSPQEMIDELSAKVVEAKALIPKIEEAAKNENLPADDKPKAEQLVSNL 6739

  Fly   511 D------ETQSQSRSQQ-------------------------VPSQAKSPSADQPRDCLAP---- 540
            :      |||...:..:                         |||..  |:..:.:|.:||    
 Worm  6740 EAFVKDVETQVSEKQDELDKLNNANDAIKRLGDALDDAEKTVVPSSV--PALSEFKDRIAPHLAT 6802

  Fly   541 ----------------------------------QKPGDEADEELEEEDEDPDIGTDV--VDFLI 569
                                              ||.||  ||:..:|.:: |:|..|  |:.::
 Worm  6803 LVEAVNDVPASVEPSAVALRDRAAKFVSDLEKNIQKTGD--DEKRADELKN-DVGNAVKNVEDVV 6864

  Fly   570 AKRSWRQVNHPNPSGT---------ATLTDFEADSESSD----------------FEQVQQLSRR 609
            :|..    |.|.|...         ||:......:||||                .:::.|...:
 Worm  6865 SKYQ----NQPQPLDVAKDDANKLKATVEQLTKLAESSDKIDPQVAKDIKDSKTKAKELLQALEK 6925

  Fly   610 GLP-----------------------------------PTVGSTRRVLNLIEMPQSSN------- 632
            .:|                                   |.|.......|.::....||       
 Worm  6926 AIPQEDAIRREQAEINDRLNNLEKELTKVDEFKPEDALPIVDQLAANTNTLKTATDSNNEKAVAP 6990

  Fly   633 SNISSSNSLLQ-------QRNHNIGNKMLPNKAHGKNIAVAVITPNSHGNTSHGHGLGHGLGHEL 690
            |::.|.:.|:.       |..|.|.:|   .:|..|..||..|.|..           ..:..:|
 Worm  6991 SSLISHDDLVVGLPEKVFQLQHAIDDK---KQALNKAAAVNEIAPKL-----------QLVSQQL 7041

  Fly   691 NKSP------LGLRKTRHHHNDTSKFNRSN---------------RKSKNCAIFYFKHLDTDNEQ 734
            ...|      |..:|......:..|.|..|               |:.....:...|  |...:.
 Worm  7042 QSVPQEVPASLDEQKQLLEDVENQKHNLENLLANLPENDPTADELRQKSQWDLSRLK--DLLKQL 7104

  Fly   735 GNAAGSDL----------QSEDDPSLIHRRRAGGDILKSADASTD-------------------- 769
            |:|.|..|          ::.:|..|...|..|||..||.|...|                    
 Worm  7105 GSAVGDKLAALAAFNAARKNAEDALLDITREDGGDDNKSPDELIDDLAKKEETVAKLLDTVSGVK 7169

  Fly   770 ----DDDEGWLYT------ATAAATL-----EVATAATAAPTAAAATSSVDGLQSTAVSSTTATG 819
                ||.|...|.      ||||..|     |:..|..|.....:...|||.:.|..|       
 Worm  7170 PDELDDKERAEYNDLLARLATAADVLKNKRAELEQAVKAKADEKSLHDSVDRIVSRLV------- 7227

  Fly   820 GPLPPSDDSDKENKVALVSATTITAAATATATSIATLHSSNYDSSSACSSSNSNSNSNSNSNGRL 884
             ||....|..:.|             |.|..|..|...........|..:..:|:.|:.....:|
 Worm  7228 -PLVRESDELRHN-------------AEAVPTQYAPKAEELKKEVEAAKAVIANAPSSDAHVQQL 7278

  Fly   885 TETSATSRVTQLQMQIHSQSQSQSQMELQINGNAIDGRHIISNNNCYSSMQHQPQNNNEGEAAED 949
            .:..||:......:    :.:::...|.....|.||.. |........::..||:.:.| |||:|
 Worm  7279 EQAVATAETLIPDL----EERARLWNEFLAARNDIDAL-IEQLQQPLDAVLAQPKRSAE-EAAQD 7337

  Fly   950 LAKIKMGDDEAAADMAN--GNATKSQQMSNGVYSR-ADSCNFTVWAAETVASCHLPPRSPAKSAK 1011
            :..:: .:.:..:|:.|  .|..:..::.:.:.|. ||...|.|.|.:|               :
 Worm  7338 VENLR-NNSQQLSDLDNKIANLQRISELLDPLESAYADVRFFDVDAEQT---------------R 7386

  Fly  1012 SSKSQASN---ATVSGSTLVSPVKGKVSH--DSIKQLVLEAEHLVRDAQETALKTPTKQKHSIIK 1071
            .......|   |.:...||:.....:|::  |.|.:::...     |.:.:.|.|..|.....:|
 Worm  7387 HQYDDVLNDVAAELEDETLLKQSASQVANEIDDISKMIDST-----DPERSILDTIAKSDIPALK 7446

  Fly  1072 ----------ISSTVKKREVTMPHPIKQRVEEWL-EHQPSTPQLLTRSHTH---ELLPSCKPDDC 1122
                      :::...::.||....|.:.::..| :.|......:..|..|   :|:.|.|.:  
 Worm  7447 AQINRIKDRIVNADASRKHVTTDPKIAEDLDNKLAKLQTELDDAIKTSDEHDKEQLILSLKLN-- 7509

  Fly  1123 EASGEASETDSVPQAGAGVNGGAPNGAGSDTSEGFTDSIATCMQTSTNSYGNSTERIGGSAEPIG 1187
                 .|:.:.:|                 ..:..:|.:.|..:..|||....      .|||:.
 Worm  7510 -----ISQFEQIP-----------------LDQLKSDDLKTAEKEITNSLKPE------EAEPLL 7546

  Fly  1188 QPVTPLGFGSSNQSLNVKIVKRSQTRRKSERPWSVSCLSQLTTDAAQLTTA----RIVENSPSGL 1248
            ..:..|           :..||.....:|.....:..|.:...|.....:|    :..:.||   
 Worm  7547 AKIQEL-----------REAKRVGDEARSAAHDQIVALEKEAEDVTAKESAKKKKKDKKKSP--- 7597

  Fly  1249 ASHSISESALDSLSPGPRPRAASSSGTGSNAAKKADSKGSLRR--RKARKKRISAASAGRKSDSG 1311
                  :..:|.||                 ||..::|..:.:  ..|:.:.:.|....:.....
 Worm  7598 ------QEMIDELS-----------------AKVVEAKALIPKIEEAAKNENLPADDKPKAEQLV 7639

  Fly  1312 SELGGDLTQTLMKSCESMSSQ---QLQEFTNALLSIQKGAVVAPLSPKGDV----------SGVP 1363
            |.|     :..:|..|:..|:   :|.:..||..:|::         .||.          |.||
 Worm  7640 SNL-----EAFVKDVETQVSEKQDELDKLNNANDAIKR---------LGDALDDAEKTVVPSSVP 7690

  Fly  1364 SLADGEGGETQLMLPKFRVGSFTTAGLLATDTRLGALAALSNYMNEDEQQAAPKPVQTRLKELST 1428
            :|::            |:            |.....||.|...:|:......|..|..|      
 Worm  7691 ALSE------------FK------------DRIAPHLATLVEAVNDVPASVEPSAVALR------ 7725

  Fly  1429 EDHHSSISETAWDNYQEKYNSENYSEGFDSD---AARRLLEFGDDYRNF---IDSQSDCCSSLSA 1487
             |..:........|.|:..:.|..::...:|   |.:.:.:....|:|.   :|...|..:.|.|
 Worm  7726 -DRAAKFVSDLEKNIQKTGDDEKRADELKNDVGNAVKNVEDVVSKYQNQPQPLDVAKDDANKLKA 7789

  Fly  1488 --------ANNLDSFSP------------------------PRMDSLQKHELKTLHINQ-----D 1515
                    |.:.|...|                        |:.|::::.:.:   ||.     :
 Worm  7790 TVEQLTKLAESSDKIDPQVAKDIKDSKTKAKELLQALEKAIPQEDAIRREQAE---INDRLNKLE 7851

  Fly  1516 TITSTVDHARRQRALEL--QYERRRKTLEVRRKSCQDMDESLMASPQS-----------DQQQQQ 1567
            ...:.||..:.:.||.:  |......||    |:..|.:.....:|.|           .::..|
 Worm  7852 KELTKVDEFKPEDALPIVDQLAANTNTL----KTATDSNNEKAVAPSSLISHDDLVVGLPEKVFQ 7912

  Fly  1568 LQ-----VTPSLSASATALMTTPKIQSTSHQISHRAESVGRKL--------DFGGMSHSAQSLLR 1619
            ||     ...:|:.:|......||:|..|.|:....:.|...|        |.....|:.::||.
 Worm  7913 LQHAIDDKKQALNKAAAVNEIAPKLQLVSQQLQSVPQEVPASLDEQKQLLEDVENQKHNLENLLA 7977

  Fly  1620 RTSESDTSTRRRRTVTADERRRSS-------RNLEKCI------KLIPATTSSSSGSDSEDGEQE 1671
            ...|:|.        ||||.|:.|       ::|.|.:      ||......:::..::||    
 Worm  7978 NLPENDP--------TADELRQKSQWDLSRLKDLLKQLGSAVGEKLAALAAFNAARKNAED---- 8030

  Fly  1672 MRSLLQQSR-DRLDDTRALKIRCHLLRPEDYNEIINTCRDNIRCLEAVLRGPPGTVLSNHCAGQT 1735
              :||..:| |..||.::         |:   |:|                              
 Worm  8031 --ALLDITREDGGDDNKS---------PD---ELI------------------------------ 8051

  Fly  1736 KDLLGAWEDLLSWSENASAARKLQQEMSVLKSSLQRLGDKPTPELLDTEPAIQIAVEALKLEQTQ 1800
                   :||....|..:   ||...:|.:|.  ..|.||...|..|....:..|.:.||.::.:
 Worm  8052 -------DDLAKKEETVA---KLLDTVSGVKP--DELDDKERAEYNDLLARLATAADVLKNKRAE 8104

  Fly  1801 LTSYRTNMLRLNA---SVHSWLTKQERRLQSALEEQEQ-QQESEQLKQQKLVEEEKGADVQKELA 1861
            |    ...::..|   |:|..:.:...||...:.|.:: :..:|.:..|   ...|..:::||:.
 Worm  8105 L----EQAVKAKADEKSLHDSVDRIVSRLVPLVRESDELRHNAEAVPTQ---YAPKAEELKKEVE 8162

  Fly  1862 STGAVAITV--TDSNGNQVE-ALATGEASTSTPAWDVHTLMSSEQEFHK----------HLKNEV 1913
            :..||....  :|::..|:| |:||.|  |..|  |:....|..:.|.|          .|:|.|
 Worm  8163 AAKAVIANAPSSDAHVQQLEQAVATAE--TLIP--DLEERASIWERFVKAKDDLYDYLEKLENNV 8223

  Fly  1914 SDMYS----SWDEADARINTQLEMLTNSLIAWRQLE---SGLSEFQLALGQDRGTLKGL------ 1965
            ||:.:    ...:|..|.| :|:..:..|...|.|:   ..|.|..|.|......|:.:      
 Worm  8224 SDVLNRPRLPVSQAQQRFN-KLKEQSYLLDRIRDLKIDFDDLGEALLPLTVAEDELRFMHVHVES 8287

  Fly  1966 -----EGALDKGQATPVELAQNVKLVAKL--LSEKVHVSQEQLLAVQQHLDPNHIYHITKFTASN 2023
                 |..:||..|   |:...|:|:..|  ||.::...:|.:                    :|
 Worm  8288 IERQYEDTMDKLNA---EITAEVELLRTLDILSNELSQCKEDI--------------------NN 8329

  Fly  2024 GSLSDSGISDGGATSDG-----------GLSERERRLGVLRRLAKQLELALAPGSEAMRSIAARM 2077
            .|:....:|.....:|.           ..||::|:. |....:..|:..||.....::.|..|:
 Worm  8330 PSVDVDELSRATMLNDAIAHLENQKVVVARSEKDRKF-VESSTSIDLDQLLAEAKRLLKEIEPRL 8393

  Fly  2078 ESAEADLKHLQNTCRDLIVRTAASHQQKQQIQQNQTQQVSPKANGHIKKQAAKGKAEPQSPGRRG 2142
            :.|:.|                  |..:..                  :...||..|        
 Worm  8394 QLAQPD------------------HDNEDD------------------EDEEKGSDE-------- 8414

  Fly  2143 KGARKARQAKKAGEDQQVEEPSLSPEQQKMVLKQLKTLTSGDGGDD-PSDDPSLL-FNLESSEED 2205
                |....:.|.|......|...|..   ||:.:       |.:: |||..|.. |:...|..|
 Worm  8415 ----KPYDVRAAAEVLSALYPDEHPHN---VLRNI-------GFEELPSDSESRSEFDSLDSRSD 8465

  Fly  2206 G--------EGADPAQTSKRGWAW-RIARAAVPMQVALFTIFCAACLMQPN-----CCDNLNNLS 2256
            |        ......|..::...| |:.|.|:|:|..|..:..||||: |:     ||..|||.:
 Worm  8466 GLLSPIPDDSTLSEEQLRRQRSRWRRVLRTALPLQALLVLLMGAACLV-PHCDDEYCCQLLNNFA 8529

  Fly  2257 MSFTPQLRYIRGPPP 2271
            .||.|.|.::.||||
 Worm  8530 KSFDPSLEFVNGPPP 8544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klarNP_001261211.1 KASH 2219..2272 CDD:287506 25/59 (42%)
anc-1NP_491353.2 CH 25..125 CDD:278723
CH 223..323 CDD:278723
mycoplas_twoTM <1952..>2078 CDD:275320
SbcC 2272..2886 CDD:223496
DUF2317 <3180..3300 CDD:302887
Smc 4938..5774 CDD:224117
DUF2317 <5037..5157 CDD:302887
Smc 5841..6677 CDD:224117 120/651 (18%)
DUF2317 <5940..6060 CDD:302887
Smc 6744..7580 CDD:224117 165/949 (17%)
DUF2317 <6843..6963 CDD:302887 18/124 (15%)
Smc 7647..8391 CDD:224117 173/894 (19%)
DUF2317 <7746..7866 CDD:302887 18/122 (15%)
KASH 8492..8544 CDD:287506 21/52 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR21524
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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