DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and hif1aa

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001295488.1	Gene:	hif1aa / 797150	ZFINID:	ZDB-GENE-080917-55	Length:	717	Species:	Danio rerio

Alignment Length:	699	Identity:	195/699 - (27%)
Similarity:	312/699 - (44%)	Gaps:	167/699 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPW 149
            |.||||||||||.|||||:..||||::.||||.::||.|||||::||.:|||:||..
Zfish    14 ERRKEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKL-------- 70

  Fly   150 TREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQV 214
                     |.|..:.:..|:|  .|..|: .|::||||.|.::|||..:|:||.||..|||.|:
Zfish    71 ---------LNSDVLEKETALD--TQWNGS-FLKALDGFLLVLSADGDIVYLSENVSKCLGLPQI 123

  Fly   215 EMTGSSIFDYIHQADHSEIADQL----GLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDD 275
            |:||.|:|::.|..||.|:.:.|    |||..|                             .|.
Zfish   124 ELTGHSVFEFTHPCDHEELREMLAHRFGLSKKS-----------------------------KDQ 159

  Fly   276 GSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNG 338
            .:                         :|||.:|||.|||.||  .:.||:.::....:...:..
Zfish   160 NT-------------------------NRSFLLRMKCTLTSRGRTVNVKSASWKVLRCSGRIHTA 199

  Fly   339 NNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECD 403
            :.........||..|.|  ::|:|:                         ::|.|:..|..|:..
Zfish   200 DGVEKEVCEEKNTCSTY--LVLICE-------------------------SIPHPANIEAPLDSR 237

  Fly   404 MFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYY 468
            .|::|...|:|..:|:.|:::||.:.|||::..|:|...||.|::.:.|:|..|..||||.||.|
Zfish   238 TFLSRHTLDMRFTYCDERITELLGFDPEDVLQHSVYEYYHALDSDHMTKTHHSLFVKGQVCTGQY 302

  Fly   469 RLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEEGL 533
            ||:.|:||:.|.:|.|||:.::||:..|.::||||::|..|....||...|...:  .||.||
Zfish   303 RLLAKAGGFVWAETQATVIYNSKNSQAQCVVCVNYILSGIEQPKQILSLQQTNST--KIKQEE-- 363

  Fly   534 GNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGH-------SHRG-RGRSAAASHGSSMNS 590
                          .:....::..::|....:.|.|..       .|.. :|.:.|.:....:.:
Zfish   364 --------------HQEEVEVTMAELKEEEKEMDKEDEECVQPVVQHNSLKGETEALTVADPVLT 414

  Fly   591 LTM-IKDSPTPLGVEI---DSGVLPTT-VATPVPAATPPVQS-TKRKRKTKASQHAEDQGQEQVI 649
            |.: |.||...:..||   :..:||:: |..|:...:||..| ...:..|...||.:...|:...
Zfish   415 LDINITDSAISVLTEIPLYNDVMLPSSDVLLPLSPLSPPCSSLNDDEASTGHLQHDQFPFQQSSD 479

  Fly   650 SEQPLPKLPTMEQRDQQPRSRLPSIVDEQPSSAADSAVK----DLEQAMSKHLP----------- 699
            |.:....||...:...|.:   |..|::..|...:|..:    |||. ::.::|
Zfish   480 SSRSQVDLPVDSELCDQLK---PDHVEKHFSMDIESKTQGVGLDLEM-LAPYIPMDDDFQLRTVS 540

  Fly   700 -------SPAAVVSVAPPNTDFSADSLLKQQQQQQQLDP--NEKSSTIQ 739
                   ||.:.:.:.|.::..::.:|..........||  .:..:|:|
Zfish   541 PVRPMCSSPCSGLDLTPSSSTQTSPALSAATPDSLSCDPVQQKNKTTVQ 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	35/51 (69%)
		PAS	176..236	CDD:214512	28/59 (47%)
		PAS	180..>236	CDD:279347	27/55 (49%)
		PAS	403..505	CDD:238075	43/101 (43%)
		PAS_3	415..502	CDD:285623	36/86 (42%)
hif1aa	NP_001295488.1	HLH	13..71	CDD:238036	38/73 (52%)
		PAS	85..150	CDD:214512	30/65 (46%)
		PAS	236..335	CDD:238075	39/98 (40%)
		PAS_3	249..336	CDD:285623	36/86 (42%)
		HIF-1	<519..541	CDD:288296	4/22 (18%)
		HIF-1a_CTAD	683..716	CDD:285931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592836
Domainoid	1	1.000	101	1.000	Domainoid score	I6867
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740