DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and SIM2

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_005060.1	Gene:	SIM2 / 6493	HGNCID:	10883	Length:	667	Species:	Homo sapiens

Alignment Length:	849	Identity:	243/849 - (28%)
Similarity:	358/849 - (42%)	Gaps:	245/849 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDPPWT 150
            ||||::||::||.|||.|||||||:||||:|||||||||||||||.||||:|..  .|.|| .|.
Human     2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGD-AWG 65

  Fly   151 REASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQVE 215
            :.:            |:..:|...:..|:|:||:||||...||:||:.:|||||.|::|||||||
Human    66 QPS------------RAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVE 118

  Fly   216 MTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGTH 280
            :||:||::|||.:||.|:...|
Human   119 LTGNSIYEYIHPSDHDEMTAVL------------------------------------------- 140

  Fly   281 GTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCNNGNNASNNA 345
             |.:..:...:.|.    |: .:|||.:|||..|.||......|||:    ..:|
Human   141 -TAHQPLHHHLLQE----YE-IERSFFLRMKCVLAKRNAGLTCSGYK----VIHC---------- 185

  Fly   346 KNVKNPGSNYSVVLLLCKLRPQYTFSHS-RKSQPPLLGMVALAIALPPPSVHEIRLECDMFVTRV 409
                   |.|      .|:| ||....| ..|...::|:||:..:|||.::.||:|..:||:.|.
Human   186 -------SGY------LKIR-QYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRA 236

  Fly   410 NFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMNKS 474
            :.||::...:.||:::..|.|:||:.|:||...|..|...||.:|..|:.||||.|.||||::|.
Human   237 SLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKR 301

  Fly   475 GGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEEGLGNDKSS 539
            ||:.|:|:.||||.:::::....|:.||||::..|.:.:.|...|:..:.........|...:.:
Human   302 GGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQET 366

  Fly   540 GSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDSPTPLGV- 603
                               .||..||                     :....|.::.:|.|...
Human   367 -------------------RKLVKPK---------------------NTKMKTKLRTNPYPPQQY 391

  Fly   604 ------EIDSGVLPTTVAT-PVPAATPPVQSTKRKRKTKASQHAEDQ----------------GQ 645
                  :::.|.|....|: |..||.||          :...|:|..                |.
Human   392 SSFQMDKLECGQLGNWRASPPASAAAPP----------ELQPHSESSDLLYTPSYSLPFSYHYGH 446

  Fly   646 EQVISEQPLPKLPTMEQRDQQPR-----------SRLPSIVDEQ--------PSSAADSAVKDLE 691
            ..:.|.....|.|.:..:..||:           |.||:..:.|        |||::.
Human   447 FPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSP------- 504

  Fly   692 QAMSKHLPSPAAVVSVAPPNT-------DFSADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPP 749
               :|:.|.|       |.||       .:.|.:...::..:....|:..|.      ..|::.|
Human   505 ---AKNPPEP-------PANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSC------GHYREEP 553

  Fly   750 APMPATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTPPGSESSYENQYLQLHSA 814
            |..||.| .||  |.|:....|.||..|....|          |.|..||:.:......|..|..
Human   554 ALGPAKA-ARQ--AARDGARLALARAAPECCAP----------PTPEAPGAPAQLPFVLLNYHRV 605

  Fly   815 -ASGGHPGGQKTSADAFTNLVSTYGGYHSSIDYHNAMTP-PSSVSPRDSNQPGKAAP------VL 871
             |..|..||   :|.|.:.|....||..::........| |::.||     ||...|      |:
Human   606 LARRGPLGG---AAPAASGLACAPGGPEAATGALRLRHPSPAATSP-----PGAPLPHYLGASVI 662

  Fly   872 ASNG 875
            .:||
Human   663 ITNG 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	39/48 (81%)
		PAS	176..236	CDD:214512	35/59 (59%)
		PAS	180..>236	CDD:279347	34/55 (62%)
		PAS	403..505	CDD:238075	42/101 (42%)
		PAS_3	415..502	CDD:285623	34/86 (40%)
SIM2	NP_005060.1	HLH	2..52	CDD:238036	40/49 (82%)
		PAS	79..>159	CDD:279347	39/128 (30%)
		PAS	88..>158	CDD:238075	35/118 (30%)
		PAS	229..328	CDD:238075	39/98 (40%)
		PAS_3	243..329	CDD:285623	34/85 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..389		8/72 (11%)
		SIM_C	359..660	CDD:284122	77/394 (20%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:14697214	367..386		5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..428		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..520		8/36 (22%)
		DUF4712	578..>653	CDD:292458	23/92 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.770