DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and SIM1

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001361698.1	Gene:	SIM1 / 6492	HGNCID:	10882	Length:	766	Species:	Homo sapiens

Alignment Length:	908	Identity:	250/908 - (27%)
Similarity:	377/908 - (41%)	Gaps:	254/908 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDPPWT 150
            ||||::|||:||.|||.|||||||:||||:|||||||||||||||.||||:|..  .|.|: .|.
Human     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGE-AWG 65

  Fly   151 REASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQVE 215
            ..:           |.|| :|...:..|:|:||:||||...||.||:.:|||||.|::|||||||
Human    66 HSS-----------RTSP-LDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVE 118

  Fly   216 MTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGTH 280
            :||:||::|||.|||.|:...|                                  .:.....:|
Human   119 LTGNSIYEYIHPADHDEMTAVL----------------------------------TAHQPYHSH 149

  Fly   281 GTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCNNGNNASNNA 345
            .....::               :|||.:|||..|.||.......||:    ..:|
Human   150 FVQEYEI---------------ERSFFLRMKCVLAKRNAGLTCGGYK----VIHC---------- 185

  Fly   346 KNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPL------LGMVALAIALPPPSVHEIRLECDM 404
                   |.|      .|:| ||:...|     |.      :|:||:..:|||.:|.||:|..:|
Human   186 -------SGY------LKIR-QYSLDMS-----PFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNM 231

  Fly   405 FVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYR 469
            |:.|.:.|:::...:.||::|..|.|:||:.|:||...|..|...||.:|..|:.||||.|.|||
Human   232 FMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296

  Fly   470 LMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPS----------- 523
            .:.|.||:.|:|:.||:|.:::::....|:.||||:::.|.:.:.|...|:..|
Human   297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSST 361

  Fly   524 PDSIKHEEGL------GNDKSSGSPGGDASG------EGNSHLSAGDMKLN---SPK----TDSE 569
            |....:.:|.      ...||..||....||      |.:.....|...|.   ||:    .|..
Human   362 PTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRP 426

  Fly   570 GHSH------RGRGRSAAASHGSSMNSLTMIKD----SPTPLGVEIDSGVLPTTVATPVPAATPP 624
            |..|      |.....::..:|.:::...::::    :....|...::|  ...:.||.....|.
Human   427 GSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAG--RYFLGTPQAGREPW 489

  Fly   625 VQSTKRKRKTKASQHAEDQGQEQVISEQPLPKLPTMEQRDQQPRSRLPSIVDE-QPSSAADSA-- 686
            ..|......||||..:.:      ..|..:|.:.::.:...:......|:|.. .|.||::|.
Human   490 WGSRAALPLTKASPESRE------AYENSMPHIASVHRIHGRGHWDEDSVVSSPDPGSASESGDR 548

  Fly   687 VKDLEQAMSKHLPSPAAVVSVAPPNTDFSADSLLKQQQQQQQL--DPNEKSSTIQWIG------- 742
            .:..:...|.|.||....:..|       ...::|:::.:.||  .|:::.::|...|
Human   549 YRTEQYQSSPHEPSKIETLIRA-------TQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCF 606

  Fly   743 TPYQQPPAPMPATALLRQLYANRESVIRATARQTPTGVGPGVFYG------------DQQTGPLP 795
            ..|||||                           |||   .|.:|            .|:.|.:.
Human   607 ANYQQPP---------------------------PTG---EVCHGSALANTSPCDHIQQREGKML 641

  Fly   796 TPPGSESSYENQYLQLHSAASGGHPGGQKTSADAFTNLVSTYGGYHSSIDYHNAMTPPSSVSPR- 859
            :|  .|:.|:|....|...:|   |...:.|.   ::|:......||.|..|.......:|||.
Human   642 SP--HENDYDNSPTALSRISS---PNSDRISK---SSLILAKDYLHSDISPHQTAGDHPTVSPNC 698

  Fly   860 ------------------------DSNQPGKAAPVLASNGG-YDYA------PDPLRGQYATS 891
                                    ||......:  |..||. :|..      |||.:|...||
Human   699 FGSHRQYFDKHAYTLTGYALEHLYDSETIRNYS--LGCNGSHFDVTSHLRMQPDPAQGHKGTS 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	40/48 (83%)
		PAS	176..236	CDD:214512	36/59 (61%)
		PAS	180..>236	CDD:279347	35/55 (64%)
		PAS	403..505	CDD:238075	40/101 (40%)
		PAS_3	415..502	CDD:285623	33/86 (38%)
SIM1	NP_001361698.1	bHLH-PAS_SIM1	1..71	CDD:381581	47/80 (59%)
		PAS	88..>158	CDD:238075	34/118 (29%)
		PAS_3	243..329	CDD:369881	33/85 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..431		15/77 (19%)
		SIM_C	360..669	CDD:369005	67/361 (19%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..563		9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157121
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.770