Protein Alignment trh and Hif3a

DIOPT Version :9

• Sequence 1: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_001375441.1
• Gene: Hif3a / 64345
• RGDID: 70332
• Length: 664
• Species: Rattus norvegicus
• Alignment Length: 827
• Identity: 210/827 - (25%)
• Similarity: 333/827 - (40%)
• Gaps: 227/827 - (27%)

  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPW 149
            |||||||||||||||.:|....|:||..||....:::.||||||:|||||||::......|:  |
  Rat    13 ELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGE--W 75

  Fly   150 TREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQV 214
            .:.......|.:.                  .|::|:||.:.:.|:|...|:||.||.:|||||:
  Rat    76 NQVGKEGEPLDAC------------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQL 122

  Fly   215 EMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGT 279
            |:.|.||||:||..|..|:.|.|
  Rat   123 ELIGHSIFDFIHPCDQEELQDAL------------------------------------------ 145

  Fly   280 HGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNGNNAS 342
              |..|.::...::|:|.      |.|.:|||||||.||  .:.|::.::..          :.|
  Rat   146 --TPRPSLSKKKSEAATG------RHFSLRMKSTLTSRGRTLNLKAATWKVL----------HCS 192

  Fly   343 NNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMFVT 407
            .:.:..|.|.              |.:.:.|.:|:|||..:|.:..|:|.|:..|..|....|::
  Rat   193 GHMRAYKPPA--------------QTSPAGSPRSEPPLQCLVLICEAIPHPASLEPPLGRGAFLS 243

  Fly   408 RVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMN 472
            |.:.|::..:|:.|::::..|||:||:..|.|...||.|::.:.:|...|:.|||.:||.||.:.
  Rat   244 RHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQAVTGQYRFLA 308

  Fly   473 KSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEEGLGNDK 537
            ::|||.|.||.||||...:....::||||:::||..|...::|   .||.:....:....||...
  Rat   309 RTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEENGVVL---SLEQTEQHTRRPPQLGTSS 370

  Fly   538 SSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDSPTPLG 602
            ..|.||                                             |||    |.|.|
  Rat   371 KKGIPG---------------------------------------------NSL----DPPAP-- 384

  Fly   603 VEIDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPKLPTMEQRDQQP 667
             .|.:.:.|..::....||.|....:...|:..|          .::...|....|:..|..::|
  Rat   385 -RILAFLHPPALSEASLAADPRRFCSPDLRRLMA----------PILDGPPTAATPSTPQAARRP 438

  Fly   668 RSRLPSIVDEQPSSAADSAVK------------DLEQAMSKHLPSPAAVVSVAP---PNTDF--- 714
            :|.||:.:.:|.:...::|.:            ||:.|..   |....:..:||   .:.||
  Rat   439 QSPLPADLPDQLAVGLENAHRLSTARKNKTMETDLDIAQD---PDTLDLEMLAPYISMDDDFQLN 500

  Fly   715 SADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAPMPATALLRQLYANRESVIRATARQTPTG 779
            |::.|.|..::..:.....::.:...:     .||.| .||.|.|                  .|
  Rat   501 SSEQLPKVHRRPPRTARRPRARSFHGL-----SPPIP-EATLLPR------------------WG 541

  Fly   780 VGPGVFYGDQQTGPLPTPPGSESSYENQYLQLHSAASGGHPGGQKTSADAFTNLVSTYGGYHS-S 843
            ..|.:.......|..||.|.:..:.:....|              :|.|....|:.|.....| .
  Rat   542 SDPRLNCSSSSKGDPPTAPLTPRTRKRALAQ--------------SSEDKGLELLETKPPKRSPR 592

  Fly   844 IDYHNAMTPPSSVS------PRDSNQPGKAAPVLASNGGYDYAPDPL 884
            ::..:.:.||.|:|      ....|||...||::.|:.....||..|
  Rat   593 LEPGSVLLPPLSLSFLLQGRQLPGNQPDPRAPLVDSHEPLGLAPSLL 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	33/51 (65%)
		PAS	176..236	CDD:214512	26/59 (44%)
		PAS	180..>236	CDD:279347	26/55 (47%)
		PAS	403..505	CDD:238075	38/101 (38%)
		PAS_3	415..502	CDD:285623	34/86 (40%)
Hif3a	NP_001375441.1	bHLH-PAS_HIF3a_PASD7	12..74	CDD:381572	34/60 (57%)
		PAS	90..145	CDD:214512	27/54 (50%)
		PAS_3	251..338	CDD:369881	34/86 (40%)
		PHA03247	<360..633	CDD:223021	67/375 (18%)
		HIF-1	477..506	CDD:402842	6/31 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351085
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740