DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and HIF3A

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_016882621.1	Gene:	HIF3A / 64344	HGNCID:	15825	Length:	755	Species:	Homo sapiens

Alignment Length:	904	Identity:	233/904 - (25%)
Similarity:	356/904 - (39%)	Gaps:	246/904 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GSLGMPAVPFTHSWMVPTQDLCAMPPYNKMTGHQQPPGAGMHAQQQPLEPGILELRKEKSRDAAR 96
            |.:..|..|..:|.  |.....|.||        .||| ...:|:.|......||||||||||||
Human    15 GVISPPCAPTRNSH--PGPGCTASPP--------APPG-WPFSQRGPGRWSTTELRKEKSRDAAR 68

  Fly    97 SRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPWTREASSSSKLKS 161
            |||.:|....|:||..||....:::.||||||:|||||||::......|:  |.:..:....|.:
Human    69 SRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGE--WNQVGAGGEPLDA 131

  Fly   162 AAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYIH 226
            .                  .|::|:||.:.:.|:|...|:||.||.:|||||:|:.|.||||:||
Human   132 C------------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIH 178

  Fly   227 QADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGTHGTNNPDVAASM 291
            ..|..|:.|.|                                            |....::...
Human   179 PCDQEELQDAL--------------------------------------------TPQQTLSRRK 199

  Fly   292 TQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNGNNASNNAKNVKNPGSN 354
            .:|.|      :|.|.:|||||||.||  .:.|::.::..          |.|.:.:..|.|.
Human   200 VEAPT------ERCFSLRMKSTLTSRGRTLNLKAATWKVL----------NCSGHMRAYKPPA-- 246

  Fly   355 YSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMFVTRVNFDLRVAHCE 419
                        |.:.:.|..|:|||..:|.:..|:|.|...|..|....|::|.:.|::..:|:
Human   247 ------------QTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCD 299

  Fly   420 PRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMNKSGGYTWLQTCA 484
            .|::::..|||:||:..|.|...||.|::.:.||...|:.|||.:||.||.:.:||||.|.||.|
Human   300 DRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQA 364

  Fly   485 TVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKH-----EEGLGNDKSSGSPGG 544
            |||...:....::|:||:::||..|...::|...|.|      :|     :.|..:.|.:.:||.
Human   365 TVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE------QHSRRPIQRGAPSQKDTPNPGD 423

  Fly   545 DASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKD-----SP---TPL 601
                           .|::|..           |..|..|..|::...:..|     ||   ..|
Human   424 ---------------SLDTPGP-----------RILAFLHPPSLSEAALAADPRRFCSPDLRRLL 462

  Fly   602 GVEIDSGVLPTTVATPVPAATP------------PVQSTKRKRKTKASQHAEDQGQEQVISEQPL 654
            |..:|...:..|.:||:....|            ||.:....|...:.:..|....:..|::...
Human   463 GPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQMRK 527

  Fly   655 PKLPTMEQRDQQPRSRLPSIVDEQPSSAADSAVKDLEQAMSKHLPSPAAVV--SVAPPNTDFSAD 717
            .||            ||.:...|..|..|.::.|       .| |||..::  ...||.   .||
Human   528 LKL------------RLLTTGTELRSDGAGTSAK-------VH-PSPRLILLPPSCPPQ---DAD 569

  Fly   718 SL-LKQQQQQQQLDPNEKSSTIQWIGTPYQQP----PAPM---------PA--TALLRQLYANRE 766
            :| |:.......:|.:.:.:..:.:...|.:|    |.|.         ||  .:||.:..::..
Human   570 ALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPR 634

  Fly   767 SVIRATARQTPTGVGP------------------GVFYGDQQTGPLPTPPGSESSYENQY---LQ 810
            ....:.:|..|:...|                  ||    :..|..|........:||..   |.
Human   635 LSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGV----ELLGVRPPKRSPSPEHENFLLFPLS 695

  Fly   811 LHSAASGG-HPGGQKTSADAFTNLVSTYGGYHSSIDYHNAMTPPSSVSP---RDSNQPG 865
            |....:|| .||..:..:....||....|            ..||.:||   .|:.|||
Human   696 LSFLLTGGPAPGSLQDPSTPLLNLNEPLG------------LGPSLLSPYSDEDTTQPG 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	33/51 (65%)
		PAS	176..236	CDD:214512	26/59 (44%)
		PAS	180..>236	CDD:279347	26/55 (47%)
		PAS	403..505	CDD:238075	39/101 (39%)
		PAS_3	415..502	CDD:285623	35/86 (41%)
HIF3A	XP_016882621.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740