Protein Alignment trh and npas3

DIOPT Version :10

• Sequence 1: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: XP_017207251.1
• Gene: npas3 / 570491
• ZFINID: ZDB-GENE-090811-1
• Length: 979
• Species: Danio rerio
• Alignment Length: 1056
• Identity: 359/1056 - (33%)
• Similarity: 491/1056 - (46%)
• Gaps: 230/1056 - (21%)

  Fly    32 GSLGMPA---VP-FTHSWMVPTQDLCA---MPPYNKMTGH------QQPPGAGMHAQQQPLEPGI 83
            |..||||   || .|:......|.|.:   ..||.:.:.:      .:|....:..||....|.:
Zfish    22 GGGGMPAASRVPGATNGNPQNVQGLTSYQQSEPYWERSANASSCSAARPKTLHLGGQQHTSSPWL 86

  Fly    84 LELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPP 148
            ..||||||||||||||||||:|||||||||||||||||||||||||||||||||:|||:..||||
Zfish    87 QALRKEKSRDAARSRRGKENFEFYELAKMLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPP 151

  Fly   149 WTRE-----ASSSSKLKSAAIRRSP---AVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETV 205
            |...     .::|.|...:..||||   |.|:||.|.|:|||||||||..|:..:||||||||||
Zfish   152 WNLRIEGPPPNTSVKAIGSQRRRSPNAMASDIFEPHLGSHILQSLDGFVFALNKEGRFLYISETV 216

  Fly   206 SIYLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTS 270
            ||||||||||:||||:|||:|..||.|:|:|||:.|..    |.|..|.|.|.          ..
Zfish   217 SIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPP----GRGLLSQGTGA----------ED 267

  Fly   271 GASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNC 335
            |||...|.:| :..|:...|.:.:..|.....:|||.:||||||||||.|.|||||:
Zfish   268 GASSASSSSH-SETPEPVESSSPSLLSPDNTLERSFFIRMKSTLTKRGVHIKSSGYK-------- 323

  Fly   336 NNGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRL 400
                                 |:.:..:||.:...:|||.....::|||.:|.|||||:::|:|:
Zfish   324 ---------------------VIHITGRLRIRMALTHSRSVPNQIMGMVVVAHALPPPTINEVRI 367

  Fly   401 ECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLT 465
            :|.|||||||.||.:.:||.|:||.:|.:|.|:|.|..|...||||...:|:||.||:.|||.:|
Zfish   368 DCQMFVTRVNMDLNIVYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRQSHLDLLNKGQCVT 432

  Fly   466 GYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSP------ 524
            .|||.:.|:|||.|:|:.||:..:.|||:|:|||.||||:||.|.::..:|..||...|
Zfish   433 KYYRWIQKNGGYIWIQSSATIAINAKNANEKNIIWVNYVLSNPEYKDTPMDIAQLPNLPEKASES 497

  Fly   525 --------DSIKHEEGLGNDKSSGSPGGDASGEGNSHLSA-------------------GDMKLN 562
                    ||.::.|...|.||.|.  |:.|.|.:....|                   ||...|
Zfish   498 SETSDSESDSKENSEDNENSKSDGK--GNQSSENSEDPEADSKKQTGRPPEQEMRRQEEGDSSSN 560

  Fly   563 SPKTDS--------------EGH--------SHRGRGR-SAAASHGSSMNSLTMIKDSPTPLGVE 604
            ....||              ||.        .|.|.|. .......||.:|....:|....:..:
Zfish   561 PESQDSDDSLEPSDCETDHKEGRLGGLHIKVEHYGDGEMEGLQDSSSSCSSEDEEEDDVEDIVKD 625

  Fly   605 IDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPKLPTMEQRDQQPRS 669
            .:||          ...:.|..|..:|||.:..:...|..::::       :|.........|.|
Zfish   626 CNSG----------GELSGPAMSKHQKRKKRRKKQKWDGSRQRL-------RLSPSAAATPSPGS 673

  Fly   670 RLPSIVDEQ----PSSAADSAVKDLEQAMSKHLPSPAAVVSVAPPNTDFSADSLLKQQQQQQQLD 730
            ..|::.|:.    |.|...|:|..::..||:.:              :|..||.:......:::.
Zfish   674 LDPTLGDQPPLLLPPSPTSSSVLKIKTEMSEPI--------------NFDNDSSIWNYPPNREIS 724

  Fly   731 PNEKSSTIQWIGTPYQQPPAPMPATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGP-- 793
            .||...::.   .|:...|:|.||                                |.|.:.|
Zfish   725 RNESPYSMT---KPHDTFPSPPPA--------------------------------GLQVSIPDS 754

  Fly   794 LPTPPGSESSYENQYLQLHSAASGGHPGGQKTSADAFT--NLVSTYGGYHSSIDYHNAMTPPSSV 856
            :.||||:||...::....:..:|.|:.....||..:.|  :||..     ||....:.::||.|.
Zfish   755 VLTPPGAESGGGSRKPNFNGNSSSGNNNNAATSVSSATSGSLVPP-----SSSTTADPLSPPLSA 814

  Fly   857 SPRDSNQPGKAAPVLASNGGYDYAPDPLRGQYATSSGDVVPATLPLKPQ-----ASYTATMHPSG 916
            ||||..|   ..|  .|:|...|..| |.......:|:||   |||..:     |:.|:|..|..
Zfish   815 SPRDKQQ---GTP--TSSGSLLYTSD-LEALQRLQAGNVV---LPLVHRVTGTLAAATSTASPRV 870

  Fly   917 STTTEGGVTYSNLDQPQYFAPHSSFHLYHKGSPASGWYSTPSXVVDDQG-QVPPSCQDQYHHHHH 980
            .||  |.:.|:..|          ..|..:|:.....: |.. .||..| .:.|....:..:||.
Zfish   871 YTT--GTIRYAPAD----------VSLAMQGNLLPNAH-TAVNFVDGPGFGIDPKTPMEMLYHHV 922

  Fly   981 HHHHQDGSAGSSASQA 996
            |..:.....|.:.|.|
Zfish   923 HRLNMSTPFGGAVSGA 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	bHLH-PAS_trachealess_like	83..152	CDD:381576	59/68 (87%)
		PAS	176..236	CDD:214512	44/59 (75%)
		PAS_3	415..502	CDD:430001	42/86 (49%)
npas3	XP_017207251.1	bHLH-PAS_NPAS3_PASD6	86..162	CDD:381575	59/75 (79%)
		PAS	190..248	CDD:214512	42/57 (74%)
		PAS_3	382..469	CDD:430001	42/86 (49%)
		PHA03269	711..>913	CDD:165527	63/263 (24%)