DRSC/TRiP Functional Genomics Resources

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Protein Alignment trh and epas1a

DIOPT Version :9

Sequence 1:NP_001261207.1 Gene:trh / 38065 FlyBaseID:FBgn0262139 Length:1022 Species:Drosophila melanogaster
Sequence 2:XP_695262.6 Gene:epas1a / 566886 ZFINID:ZDB-GENE-030131-4490 Length:843 Species:Danio rerio


Alignment Length:814 Identity:227/814 - (27%)
Similarity:326/814 - (40%) Gaps:253/814 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDP 147
            |.||||||||||.||.||...|||||..||||.:|:|.||||||:||.||:|:.|..  |||   
Zfish    13 ERRKEKSRDAARCRRSKETEVFYELAHQLPLPHSISSHLDKASIMRLAISFLRTRKLFSSGH--- 74

  Fly   148 PWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLS 212
              |.:...|..|       ....:|:        |:||:||.:.|.:||..:::||.||.::||:
Zfish    75 --TVQQMRSQNL-------GQMDNLY--------LKSLEGFVIVVTSDGDMIFLSENVSKFMGLT 122

  Fly   213 QVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGS 277
            |||:||.||||:.|..||.||.:  .||:.||                       |..|...   
Zfish   123 QVELTGHSIFDFTHPCDHEEIRE--NLSIKSG-----------------------PVYGRKG--- 159

  Fly   278 GTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNGNN 340
                          .:.|||      |.|.:|||.|:|.||  .:.||:.::....|.:      
Zfish   160 --------------KEMSTS------RDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGH------ 198

  Fly   341 ASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMF 405
                              |.:|..||.......  |:|||..:..|...:|.||..:..|:...|
Zfish   199 ------------------LQVCSSRPPQILCGF--SEPPLTCITMLCAPIPHPSNVDTPLDSKTF 243

  Fly   406 VTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRL 470
            ::|.:.|::..:|:.|||.|:.|.||:|:.:|:|..|||.|:..:.|||.:|..||||::|.||:
Zfish   244 MSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFCHALDSENMTKSHQNLCNKGQVVSGQYRM 308

  Fly   471 MNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMIL-------------------- 515
            :.|:|||.|::|.|||:.:.:|:..|.|||:||::|:.|.:::|.                    
Zfish   309 LAKNGGYVWVETQATVIYNNRNSQPQCIICINYILSSVEEQSVIFSLDQTEALFKPYHTYDMGEI 373

  Fly   516 -----------------------DCCQLEPSP-DSI--------KHEEGLGNDKSSGSPG----- 543
                                   :..||.|.| |:|        :.||.....|||..|.     
Zfish   374 FSQNTSISEPQNNLFTTLKEEPEELAQLAPMPGDAIIALDFERAEFEEATFFSKSSKLPAVGPSW 438

  Fly   544 -----GDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDSPT---- 599
                 .|.|.|.|  ||:.......|:....|..      :...:...|..|.....:||.    
Zfish   439 VVDTPPDGSPERN--LSSLPSSFTVPQVPPAGKC------TPCTTPCLSSCSSCSTPNSPVDCCG 495

  Fly   600 ----PLGVEIDSGVLPTTVATPVPAATPPVQS----TKRKRKTKA---SQHAEDQGQEQVISEQP 653
                .|.||     |...:..|...||.|..|    :....:|.|   ....||.....:..|:|
Zfish   496 SGEWDLKVE-----LTEKLFAPESGATNPTDSQLNLSDLDLETLAPYIPMDGEDFQLHPICLEEP 555

  Fly   654 LPKL-PTMEQRDQ----------QPRSRLPSIVDEQPSSAADSAVKDLEQAMSKHLPSPAAVVSV 707
            :|.. |.:....|          ||..:.|..:..:||:..||.          |: .|....  
Zfish   556 VPDAGPGLSAAVQHSFSSVADLFQPLGQYPPYIKNRPSTCPDST----------HI-QPYQTT-- 607

  Fly   708 APPNTDFSADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAPMPATALLRQLYANRESVIRAT 772
              ||...|::   ||:|            ::.|       ||..:          :..|:.....
Zfish   608 --PNIPLSSE---KQRQ------------SLHW-------PPDQL----------SQYENTNVGC 638

  Fly   773 ARQTPTGVGPGVFYGDQQTGPLPTPPGSESSYEN 806
            .....|| |||      ||.....||..:..:||
Zfish   639 MDDRNTG-GPG------QTCNFNVPPPHQRFFEN 665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trhNP_001261207.1 HLH 85..137 CDD:238036 36/51 (71%)
PAS 176..236 CDD:214512 28/59 (47%)
PAS 180..>236 CDD:279347 28/55 (51%)
PAS 403..505 CDD:238075 45/101 (45%)
PAS_3 415..502 CDD:285623 40/86 (47%)
epas1aXP_695262.6 HLH 12..68 CDD:238036 37/54 (69%)
PAS 86..147 CDD:214512 29/70 (41%)
PAS 240..339 CDD:238075 42/98 (43%)
PAS_3 253..340 CDD:285623 40/86 (47%)
HIF-1 522..554 CDD:288296 5/31 (16%)
HIF-1a_CTAD 806..842 CDD:285931
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170592823
Domainoid 1 1.000 101 1.000 Domainoid score I6867
eggNOG 1 0.900 - - E1_KOG3558
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000232
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.740

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