DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trh and sim1b

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001153057.1	Gene:	sim1b / 566656	ZFINID:	ZDB-GENE-041210-5	Length:	586	Species:	Danio rerio

Alignment Length:	776	Identity:	222/776 - (28%)
Similarity:	338/776 - (43%)	Gaps:	217/776 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDPPWT 150
            ||||:.|||:||.|||.||||||||||||:|||||||||||||||.||||:|..  .|.|: .|.
Zfish     2 KEKSKTAARTRREKENSEFYELAKMLPLPSAITSQLDKASIIRLTSSYLKMRLVFPQGLGE-VWG 65

  Fly   151 REASSSSKLKSAAIRRSPAVDLFEQHQGTHI--------LQSLDGFALAVAADGRFLYISETVSI 207
            :...:.|       ..:|:.:|     |:|:        ||:||||...|||||:.:|||||.|:
Zfish    66 QAGRTRS-------GENPSHEL-----GSHLLQVIISKMLQTLDGFIFVVAADGKIMYISETASV 118

  Fly   208 YLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGA 272
            :|||||||:||:||::|:|.|||.|:|..|
Zfish   119 HLGLSQVELTGNSIYEYVHPADHDEMAAVL----------------------------------- 148

  Fly   273 SDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCNN 337
                     |..|...:...|.    |: .:|||.:|||..|.||.....|.||:    ..:|
Zfish   149 ---------TPQPSYHSHFVQE----YE-VERSFFLRMKCVLAKRNAGLTSGGYK----VIHC-- 193

  Fly   338 GNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPL------LGMVALAIALPPPSVH 396
                           |.|      .|:| |::...|     |.      :|:||:...|||.:|.
Zfish   194 ---------------SGY------LKIR-QFSLDAS-----PFDGCYQNVGLVAVGHTLPPSAVT 231

  Fly   397 EIRLECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKG 461
            ||:|..:||:.|.:.|:::...:.|||||..|.|:||:.|:||...|..|:..||.:|..|:.||
Zfish   232 EIKLHSNMFMFRASLDMKLIFLDSRVSDLTGYEPQDLIEKTLYHHVHCCDSFHLRCAHHLLLVKG 296

  Fly   462 QVLTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDS 526
            ||.|.|||.::|.||:.|:|:.||:|.:::::....|:.||||:::.|.:.:||...||.|...:
Zfish   297 QVTTKYYRFLSKRGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLILSLDQLNPRKPA 361

  Fly   527 IKHEEGLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSL 591
            ..:    .|...........|....||.|.........::||:              |.|....
Zfish   362 FPY----ANHSDKTHTTNSRSKILLSHYSQQFSSFPPDRSDSD--------------HDSQWED- 407

  Fly   592 TMIKDSPTPLGVEIDSGVLPTTVATPVPAATPPVQSTKRKR-----KTKASQHAEDQGQEQVISE 651
            :.:.||.:|..::....|..:...:.|..:.....:....|     ...|:||:.
Zfish   408 SPLTDSASPQRLDRSDSVCFSLAQSDVMQSCSQTHTPLFNRDGWWDARAANQHSH---------- 462

  Fly   652 QPLPKLPTMEQRDQQPRSRLPSIVDEQ-PSSAADSAVKDLEQAMSKHLPSPAAVVSVAPPN-TDF 714
                                 ::.||. .||:|.||  |..|::.:..|.   ::.|...: .|:
Zfish   463 ---------------------AVWDEDLSSSSAQSA--DGAQSLIRAAPE---LIKVEEAHMRDY 501

  Fly   715 SADSLLKQQQQQQQLDPNEKSSTIQWIGTP-YQQPPAPMPATALLRQLYANRESVIRATARQTPT 778
            |:.||....:.:.. ||:...:::..:.:| ..:|..|:.|
Zfish   502 SSSSLFSSARHRDG-DPDGSPASLSALSSPGSDRPSQPLSA------------------------ 541

  Fly   779 GVGPGVFYGDQQTGPLPTPPGSESSYENQYLQLHSAASGGHPGGQ-KTSADAFTNLVSTYG 838
                             :||..|:::.:..|:.:||....:...| .|:|...|:::.|.|
Zfish   542 -----------------SPPALETTHTHPSLRAYSAHYDINTHFQSSTTAHNGTSVIITNG 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	41/48 (85%)
		PAS	176..236	CDD:214512	37/67 (55%)
		PAS	180..>236	CDD:279347	36/63 (57%)
		PAS	403..505	CDD:238075	42/101 (42%)
		PAS_3	415..502	CDD:285623	35/86 (41%)
sim1b	NP_001153057.1	HLH	2..52	CDD:238036	42/49 (86%)
		PAS	92..>149	CDD:279347	36/100 (36%)
		PAS	92..148	CDD:214512	35/55 (64%)
		PAS	237..336	CDD:238075	39/98 (40%)
		PAS_3	251..337	CDD:285623	35/85 (41%)
		SIM_C	357..>498	CDD:284122	30/195 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.770