DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trh and epas1b

DIOPT Version :9

Sequence 1:NP_001261207.1 Gene:trh / 38065 FlyBaseID:FBgn0262139 Length:1022 Species:Drosophila melanogaster
Sequence 2:NP_001034895.2 Gene:epas1b / 555192 ZFINID:ZDB-GENE-060607-11 Length:834 Species:Danio rerio


Alignment Length:906 Identity:233/906 - (25%)
Similarity:362/906 - (39%) Gaps:265/906 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDP 147
            |.||||||||||.||.||...|||||..||||.:|:|.||||||:||.||:|:.|..  ||:..|
Zfish    13 ERRKEKSRDAARCRRSKETEVFYELAHHLPLPHSISSHLDKASIMRLAISFLRTRKLVNSGYNTP 77

  Fly   148 PWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLS 212
               .|.:.:.:|                 ..:..|:||.||...|.:||..:::||.::.::||:
Zfish    78 ---TEMTDADRL-----------------MDSWYLKSLGGFITVVTSDGDMIFLSENINKFMGLT 122

  Fly   213 QVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGS 277
            |||:||.||||:.|..||.||.:  .|||.:|.|..|...|:                       
Zfish   123 QVELTGHSIFDFTHPCDHEEIRE--NLSLKAGIGKKGKELST----------------------- 162

  Fly   278 GTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSN---CNN 337
                                     :|.|.:|||.|:|.||  .:.||:.::....|.:   ||.
Zfish   163 -------------------------ERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKVCNG 202

  Fly   338 GNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLEC 402
                                    |..|....|     .:|||..:|.:...:..||..:..|:.
Zfish   203 ------------------------CPARVLCGF-----KEPPLTCVVMMCEPIVHPSNIDTPLDS 238

  Fly   403 DMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGY 467
            ..|::|.:.|::..:|:.||::|:.|:||||:.:|.|...||.||..:.|||.:|..|||.::|.
Zfish   239 KTFLSRHSMDMKYTYCDERVTELMGYNPEDLLGRSAYEFYHALDAENVTKSHQNLCTKGQAVSGQ 303

  Fly   468 YRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEP--SPDSI--- 527
            ||::.|:|||.|::|..||:.:::|:..|.|:|||||:|:.|.:::|....|.|.  .|..:   
Zfish   304 YRMLAKNGGYVWVETRGTVIYNSRNSQPQCIVCVNYVLSDVEEKSLIFSMDQTESLFKPHKLNGF 368

  Fly   528 -KHEEGLGNDKS-----------------SGSPG--------GDASGEGN---SHLSAGDMKLNS 563
             ..:|.||:|.:                 :.:||        |.:..|.:   :.:|:....::.
Zfish   369 FSPKEALGSDPADLLFTKLKEEPEDLTQLAPTPGDTIISLDFGQSQYEEHTVYNKVSSVAQTVSH 433

  Fly   564 PKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDSPTPLGVEIDSGVLPTTVATPVPAATPPVQST 628
            |..|....|:.|.....||:.....::   ...|.||......:...|....|||.:.. .|:.|
Zfish   434 PVHDGHRTSYSGEMAKMAATFSVPQSA---PPSSATPSLSSCSTPSSPDDYYTPVDSDL-KVELT 494

  Fly   629 KRKRKTKASQHAEDQGQEQVISEQPL----PKLPTMEQRDQQPRSRLPSIVDEQPSSAAD----- 684
            ::.......:....:.||..:|:..|    |.:| |:..|.|    |..|..|:|.|...     
Zfish   495 EKLFSLDTQEAKTSRNQETDLSDLDLETLAPYIP-MDGEDFQ----LNPICPEEPPSEIGTLGTN 554

  Fly   685 ----SAVKDLEQAMSKHLPSPAAV-------------------VSVAPPNTDFSADSLLKQQQQQ 726
                |.:..|.|.:|    ||:|.                   |...|| ..:|.|.:       
Zfish   555 QQCFSNITSLFQPLS----SPSAAHYQPKMSSGGDKQNINGGSVESWPP-VPYSRDPM------- 607

  Fly   727 QQLDP-NEKSST----------IQWIGTPYQQPPAPMPATA-LLRQLYANRESVIRATARQTPTG 779
             |:.| ::.:||          :||      .|..|:|:.| ::..|.|.|........|..|..
Zfish   608 -QMPPYHDPASTPLSSMGGRQNLQW------PPDPPLPSKAGMMDPLAAKRSCQGMPANRMAPFM 665

  Fly   780 VGPGVFYGDQQTGPLPTPPGSESSYENQYLQLHSAASGGHPGGQKTSADAFTNLVSTYGGYHSSI 844
            ..|...:........|......:|::..:.|:..|.                             
Zfish   666 QRPMENFVQNYRDTSPARLALANSFKRSFSQMAMAE----------------------------- 701

  Fly   845 DYHNAMTPPS---------------SVSPRDS-NQPGKAAPVLASNGGYDYAPDPLRGQYA 889
                  |||:               :|..|.| :....:...:|.|||.|:  ...:.||:
Zfish   702 ------TPPTKSQQTVWKKLRHESCAVMERKSLSSSALSDKSMAHNGGMDH--QHRKSQYS 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trhNP_001261207.1 HLH 85..137 CDD:238036 36/51 (71%)
PAS 176..236 CDD:214512 26/59 (44%)
PAS 180..>236 CDD:279347 26/55 (47%)
PAS 403..505 CDD:238075 43/101 (43%)
PAS_3 415..502 CDD:285623 37/86 (43%)
epas1bNP_001034895.2 HLH 12..68 CDD:238036 37/54 (69%)
PAS 92..147 CDD:214512 26/56 (46%)
PAS 238..337 CDD:238075 39/98 (40%)
PAS_3 251..338 CDD:285623 37/86 (43%)
HIF-1 511..543 CDD:288296 11/36 (31%)
HIF-1a_CTAD 798..833 CDD:285931
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170592822
Domainoid 1 1.000 101 1.000 Domainoid score I6867
eggNOG 1 0.900 - - E1_KOG3558
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000232
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.740

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