DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and hif1a

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_031746581.1	Gene:	hif1a / 496583	XenbaseID:	XB-GENE-946622	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	779	Identity:	208/779 - (26%)
Similarity:	316/779 - (40%)	Gaps:	208/779 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPW 149
            |.||||||||||.||.||:..||||:..||||..::|.||||||:|||||||::|.....||...
Frog    16 ERRKEKSRDAARCRRSKESEVFYELSHELPLPHNVSSHLDKASIMRLTISYLRIRRLLDAGDLDG 80

  Fly   150 TREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQV 214
            ..|                    .::......|::|:||.|.:..:|..:|:||.|:..:||:|.
Frog    81 ETE--------------------LDKQLNCFYLKALEGFVLVLTEEGDMIYLSENVNKCMGLTQF 125

  Fly   215 EMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGT 279
            |:||.|:||:.|..||.|:.:.|...                 .|.|..|....|
Frog   126 ELTGHSVFDFTHPCDHEELREMLTFR-----------------NGPAKKGKEQIT---------- 163

  Fly   280 HGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATS-----NCNN 337
                                   :|||.:|||.|||.||  .:.||:.::....|.     :.||
Frog   164 -----------------------ERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHMRVYDANN 205

  Fly   338 GNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLEC 402
            .|                                |....:||:..||.:...:|.||..|..|:.
Frog   206 HN--------------------------------HCGYKKPPMTCMVIICEPIPHPSNIEFPLDS 238

  Fly   403 DMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGY 467
            ..|::|.:.|::.::|:.||::|:.|.|::|:.:|:|...||.|::.|.|:|.::..||||.||.
Frog   239 KTFLSRHSLDMKFSYCDERVTELVGYEPDELLGRSVYEYYHALDSDHLTKAHHNMFTKGQVTTGQ 303

  Fly   468 YRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILD----CCQLEP-SPDSI 527
            ||::.|.|||.|::|.|||:.::||:..|.|:|||||:|....:::||.    .|.|.| ....:
Frog   304 YRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTACVLSPVESQEM 368

  Fly   528 KHEE---GLGNDKSSGSPGGDASGEGNSHL----SAGDMKLNSPKTDSEGHSHRGRGRSAAASHG 585
            |..|   .|..|.::.........|..|..    .|||..:                 |...|.|
Frog   369 KMPEIFTELNEDNNAECLFEKLKQEPESLTVLAPDAGDEII-----------------SLDFSSG 416

  Fly   586 SSMNSLTMIKDSP---TPLGVEI----DSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAEDQ 643
            .|        |.|   .||..::    .|..|.:|..||:||:..|        |...|......
Frog   417 DS--------DKPYEDVPLYNDVMLHSTSKKLESTPVTPLPASEMP--------KPLRSNVDPAL 465

  Fly   644 GQEQVISEQPLPK-------LPTMEQRDQQPRSRLPSIVDEQPSSA-----------ADSAVK-- 688
            .:|.||..:..|:       :|.:.:.|.      ||.:....||.           .||.:.
Frog   466 NREVVIKMESNPEQLELTFTIPQLSKPDS------PSDISSSQSSTEPSTPPEYCFDVDSEIASE 524

  Fly   689 ---DLEQ---AMSKHLPSPAAV------VSVAPPNTDFSADSLLKQQQQQQQLDPNEKSSTIQWI 741
               ||.:   |:.....:|.:.      :.:..|......|..|:...|...|:.:  ||..|.:
Frog   525 FKLDLVEKLFAIDTEAKAPFSTQETDLDLEMLAPYIPMDDDFQLRTFDQLSSLECD--SSNPQTL 587

  Fly   742 G---TPYQQPPAPMPATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTPPGSES 802
            |   |.:||...|..:.........:.:::|::.....|.    ..|.|::.....|..|...:
Frog   588 GSMATLFQQSLLPSSSDFKPEDAINDLKTIIQSPVHSAPA----SPFDGNRSRTSSPVRPAKSA 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	36/51 (71%)
		PAS	176..236	CDD:214512	23/59 (39%)
		PAS	180..>236	CDD:279347	23/55 (42%)
		PAS	403..505	CDD:238075	43/101 (43%)
		PAS_3	415..502	CDD:285623	37/86 (43%)
hif1a	XP_031746581.1	bHLH-PAS_HIF1a_PASD8	13..83	CDD:381570	40/66 (61%)
		PAS	93..148	CDD:214512	23/54 (43%)
		PAS_11	241..343	CDD:405306	44/101 (44%)
		HIF-1	549..575	CDD:402842	4/25 (16%)
		HIF-1a_CTAD	761..795	CDD:400914
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000