DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and NPAS2

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_005264010.1	Gene:	NPAS2 / 4862	HGNCID:	7895	Length:	889	Species:	Homo sapiens

Alignment Length:	979	Identity:	206/979 - (21%)
Similarity:	352/979 - (35%)	Gaps:	268/979 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELRKEKSRDAARS-----RRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGH 144
            |..|::::.|:|:     ||.:.|....||:.|||   ..|.::||.:::...|.:|:..:
Human    68 EDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHN---- 125

  Fly   145 GDPPWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHI-LQSLDGFALAVAADGRFLYISETVSIY 208
                   |.|:.:::  ..|::..........:.|.: |::||||.:||..||..:|:|::::..
Human   126 -------EVSAQTEI--CDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPL 181

  Fly   209 LGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGAS 273
            ||....::...::.:::.:.:|||:...|...:.                             .:
Human   182 LGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML-----------------------------VT 217

  Fly   274 DDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCNNG 338
            |..|..:..::.|:                ..:|..::.:|..:  .|.:..|...       .|
Human   218 DSPSPEYLKSDSDL----------------EFYCHLLRGSLNPK--EFPTYEYIKF-------VG 257

  Fly   339 NNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPL------LGMVALAIALPPPSVHE 397
            |..|.|  ||.:|..|            .:..:.||..:.||      :..|.||   .|..:.|
Human   258 NFRSYN--NVPSPSCN------------GFDNTLSRPCRVPLGKEVCFIATVRLA---TPQFLKE 305

  Fly   398 IRL---ECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIE 459
            :.:   ..:.|.:|.:.:.:....:.|...::.|.|.:::..|.|...|.:|...|.:.|..|::
Human   306 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQ 370

  Fly   460 KGQVLTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVIS------NRENENMILDCC 518
            .|:..:..||.:.|...:.||||...:.....|:..:.|:|.:.|:|      .|..|      .
Human   371 FGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQE------L 429

  Fly   519 QLEPSPDSIKHEEGLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAAS 583
            .||..|....|...|   |..||     |.|...|.:..|:..:...|   .||.....||   |
Human   430 ALEDPPSEALHSSAL---KDKGS-----SLEPRQHFNTLDVGASGLNT---SHSPSASSRS---S 480

  Fly   584 HGSSMNSLTMIKDSPTPLGVEIDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAEDQGQEQV 648
            |.||..:::....:||.|..|..:..||.:...|
Human   481 HKSSHTAMSEPTSTPTKLMAEASTPALPRSATLP------------------------------- 514

  Fly   649 ISEQPLPKLPTMEQRDQQPRSRLPSIVDEQPSSAADSAVKDLEQAMSKHLPSPAAVVSVAPPNTD 713
               |.|| :|.:.|....| :.|||     ||| .|...:.|.|.:.:..|:|.|..|     ..
Human   515 ---QELP-VPGLSQAATMP-APLPS-----PSS-CDLTQQLLPQTVLQSTPAPMAQFS-----AQ 563

  Fly   714 FSADSLLKQQ-------------QQQQQLDPNE------KSSTIQWIGTPYQQPPAPMPATALLR 759
            ||....:|.|             .||::|...:      :.|.:|..   .|||...:..::..|
Human   564 FSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMF---LQQPAVSLSFSSTQR 625

  Fly   760 QLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTPPGSESSYE--NQYLQLHS---AASGGH 819
            .....:.....|...|...|.||.:             ||..||.:  :|:|...|   :..|..
Human   626 PEAQQQLQQRSAAVTQPQLGAGPQL-------------PGQISSAQVTSQHLLRESSVISTQGPK 677

  Fly   820 P--GGQ--KTSADAFTNLVSTYGGYHSSIDYHNAMTPPSSVSPRDSNQ----------------- 863
            |  ..|  ::|..:.::|||.:....:::.....:|.|:|.| :|::|
Human   678 PMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTS-QDASQCQPSPDFSHDRQLRLLL 741

  Fly   864 --------PGKA---APVLASNGG--YDYAPDPLRGQYATSSGDVVPA---TLPLKPQASYTATM 912
                    ||..   .|...|..|  ..||    :.|....:.|..||   :.|:.......|.:
Human   742 SQPIQPMMPGSCDARQPSEVSRTGRQVKYA----QSQTVFQNPDAHPANSSSAPMPVLLMGQAVL 802

  Fly   913 HPSGSTTTEGGVTYSNLDQ--PQYF----APHSSFHLYHKGSPASGWYS-TPSXVVDDQGQVPPS 970
            |||...:....:..:...|  ||::    || :|.|...:.|.....|| .|. :...|   ||.
Human   803 HPSFPASQPSPLQPAQARQQPPQHYLQVQAP-TSLHSEQQDSLLLSTYSQQPGTLGYPQ---PPP 863

  Fly   971 CQDQ 974
            .|.|
Human   864 AQPQ 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	16/56 (29%)
		PAS	176..236	CDD:214512	17/60 (28%)
		PAS	180..>236	CDD:279347	16/56 (29%)
		PAS	403..505	CDD:238075	23/101 (23%)
		PAS_3	415..502	CDD:285623	21/86 (24%)
NPAS2	XP_005264010.1	HLH	72..126	CDD:238036	15/67 (22%)
		PAS	149..214	CDD:214512	18/64 (28%)
		PAS_9	159..260	CDD:290162	24/154 (16%)
		PAS_11	314..417	CDD:291273	24/102 (24%)
		PAS	315..415	CDD:238075	23/99 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910