DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and NPAS1

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_002508.2	Gene:	NPAS1 / 4861	HGNCID:	7894	Length:	590	Species:	Homo sapiens

Alignment Length:	798	Identity:	273/798 - (34%)
Similarity:	360/798 - (45%)	Gaps:	243/798 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PTPGH-PGSHMATMGSLGMPAVPFTHSWMVPTQDLCAMPPYNKMTG--HQQPPGAGMHAQQQPLE 80
            |.||. .||.:..:|..|                  |..|::.:.|  .:.|.|..:.||
Human     4 PYPGSGGGSEVKCVGGRG------------------ASVPWDFLPGLMVKAPSGPCLQAQ----- 45

  Fly    81 PGILELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHG 145
                  ||||||:||||||||||.||:||||:||||.||:||||||||:||:::||:||.|:..|
Human    46 ------RKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG 104

  Fly   146 DPPW-TREASSSSKLKSAAIRRSPAV---DLFEQHQGTHILQSLDGFALAVAADGRFLYISETVS 206
            .||| .|.|...:.|  |..||.||.   ::||||.|.|||||||||..|:..:|:|||||||||
Human   105 APPWGLRAAGPPAGL--APGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVS 167

  Fly   207 IYLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSG 271
            ||||||||||||||:|||||..||||:.:||||...:                   .|..:|.|.
Human   168 IYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPT-------------------PGPPTPPSV 213

  Fly   272 ASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCN 336
            :|...|.:...:.|::.||:|:...|... .:|||.|||||||||||.|.|:|||:....|.
Human   214 SSSSSSSSSLADTPEIEASLTKVPPSSLV-QERSFFVRMKSTLTKRGLHVKASGYKVIHVTG--- 274

  Fly   337 NGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLE 401
                                      :||     :|:       ||:|||...|||..:.|:.|.
Human   275 --------------------------RLR-----AHA-------LGLVALGHTLPPAPLAELPLH 301

  Fly   402 CDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTG 466
            ..|.|.|::..|.:..||.||||.:|..|.:||.:|.|...|.:||.|:|:||.||::||||:||
Human   302 GHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTG 366

  Fly   467 YYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEE 531
            |||.:.::||:.|||:.|||..|.|:..|.:::.|::|:|..|.....||..||   |.|:..||
Human   367 YYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL---PASVACEE 428

  Fly   532 GLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKD 596
                   :.|||.:.:               .|:..:||.      ::|.|.:.:.......||.
Human   429 -------ASSPGPEPT---------------EPEPPTEGK------QAAPAENEAPQTQGKRIKV 465

  Fly   597 SPTPLGVEIDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPKLPTME 661
            .|.|                               |:||.|   ||.|
Human   466 EPGP-------------------------------RETKGS---EDSG----------------- 479

  Fly   662 QRDQQPRSRLPSIVDEQPSSAADSAVKDLEQAMSKHLPSPAAVVSVAPPNTDFSADSLLKQQQQQ 726
                          ||.|||               |..:|      .|..|......:|||
Human   480 --------------DEDPSS---------------HPATP------RPEFTSVIRAGVLKQ---- 505

  Fly   727 QQLDPNEKSSTIQW-IGTPYQQPPAPMPATALLRQLYANRESVIRATARQTPTGVGP---GVFYG 787
               ||     ...| :..|...||..:.|..|        ..|:|..........||   |:.|.
Human   506 ---DP-----VRPWGLAPPGDPPPTLLHAGFL--------PPVVRGLCTPGTIRYGPAELGLVYP 554

  Fly   788 D-QQTGPLPTPPGSESSY 804
            . |:.||.|..|  |:.|
Human   555 HLQRLGPGPALP--EAFY 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	39/51 (76%)
		PAS	176..236	CDD:214512	45/59 (76%)
		PAS	180..>236	CDD:279347	43/55 (78%)
		PAS	403..505	CDD:238075	46/101 (46%)
		PAS_3	415..502	CDD:285623	41/86 (48%)
NPAS1	NP_002508.2	HLH	45..96	CDD:238036	40/61 (66%)
		PAS	141..198	CDD:214512	43/56 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		9/49 (18%)
		PAS_3	315..386	CDD:312074	36/70 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..494		29/182 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157120
Domainoid	1	1.000	96	1.000	Domainoid score	I7336
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2288
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm41630
orthoMCL	1	0.900	-	-		OOG6_107023
Panther	1	1.100	-	-	LDO	PTHR23043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.830