Protein Alignment trh and sim

DIOPT Version :9

• Sequence 1: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 238/905 - (26%)
• Similarity: 356/905 - (39%)
• Gaps: 307/905 - (33%)

  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDPPWT 150
            ||||::|||:||.|||.||.||||:|||||||||||||||:||||.||||:|..  .|.|: .|
  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGE-AW- 88

  Fly   151 REASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQVE 215
              .||.:..:.|.|:          ..|:|:||:||||...||.||:.:|||||.|::|||||||
  Fly    89 --GSSPAMQRGATIK----------ELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVE 141

  Fly   216 MTGSSIFDYIHQADHSEI---------ADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSG 271
            :||:|||:|||..|..|:         .:|..|:.|.             ...|:..|:..|:
  Fly   142 LTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTH-------------TPIGSPNGVQHPS-- 191

  Fly   272 ASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCN 336
            |.|...|:|...                  .:::|.:|||..|.||.....:||::    ..:|
  Fly   192 AYDHDRGSHTIE------------------IEKTFFLRMKCVLAKRNAGLTTSGFK----VIHC- 233

  Fly   337 NGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLE 401
                            |.|    |..::.|..  ...:.|....||:||:..:||..::.||:|.
  Fly   234 ----------------SGY----LKARIYPDR--GDGQGSLIQNLGLVAVGHSLPSSAITEIKLH 276

  Fly   402 CDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTG 466
            .:||:.|...|:::...:.|||.|..|.|:||:.|:||...||.|...:|.||..|:.||||.|.
  Fly   277 QNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTK 341

  Fly   467 YYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEE 531
            |||.:.|.||:.|:|:.||:|.:::::.|..|:.||||:|.||.::::|:
  Fly   342 YYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLN--------------- 391

  Fly   532 GLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKD 596
                                                                             
  Fly   392 ----------------------------------------------------------------- 391

  Fly   597 SPTPLGVEIDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAE----DQGQEQVISEQPLPKL 657
                   ||.:||:.....:|...|....|:.:..:..:|:|.|.    .|.|..|:.:|.:...
  Fly   392 -------EIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQ 449

  Fly   658 PTMEQRDQQPRSRLPSIVDEQPSSAADSAVKDLEQAMSKHLPSPAAVVSVAPPNTDFSADS---- 718
            |.......||      :....|.|.|.||...|:......||...||..|.|.|...|:.:
  Fly   450 PQCAGATGQP------VGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNG 508

  Fly   719 -----LLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAPMPATALLRQLYANRESVIRATARQTPT 778
                 .::||||...:|.:..|.|                      |||.....::.:::    :
  Fly   509 VWHHHHVQQQQQSGSMDHDSLSYT----------------------QLYPPLNDLVVSSS----S 547

  Fly   779 GVGPGVFYGDQQTGPLPTPPGSESSYENQYLQLHSAASGGHPGGQKTSADA-------------- 829
            .||.|                             :|:|.|  ||...||.:
  Fly   548 SVGGG-----------------------------TASSAG--GGSSASASSSGVYSTEMQYPDTT 581

  Fly   830 -----FTNLVSTYGGYHSSIDYHNAMTPPSSVSPRDSNQPGKAAPVLASNGGYDYAPDPLRGQYA 889
                 :.|....|..|.:::|...:|..|.|.:....:...::                 ..|.:
  Fly   582 TGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSES-----------------ERQLS 629

  Fly   890 TSSGDVVPATLPLKPQASYTATMHPSGSTTTEGGVTYSNLD---QPQYFAPHSSFHLYHK 946
            |.:..:|..|.|.:                    .|||:|.   :..||:.:||....|:
  Fly   630 TGNASIVNETSPSQ--------------------TTYSDLSHNFELSYFSDNSSQQHQHQ 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	39/48 (81%)
		PAS	176..236	CDD:214512	35/68 (51%)
		PAS	180..>236	CDD:279347	34/64 (53%)
		PAS	403..505	CDD:238075	43/101 (43%)
		PAS_3	415..502	CDD:285623	36/86 (42%)
sim	NP_524340.2	HLH	26..78	CDD:238036	41/51 (80%)
		PAS	102..215	CDD:279347	49/145 (34%)
		PAS	102..163	CDD:214512	35/60 (58%)
		PAS	278..376	CDD:238075	40/97 (41%)
		PAS_3	291..377	CDD:285623	36/85 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I7753
eggNOG	1	0.900	-	-		E1_KOG3558
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I3384
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm14250
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
	10	10.000