DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and hif1ab

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001296971.1	Gene:	hif1ab / 393202	ZFINID:	ZDB-GENE-040426-706	Length:	777	Species:	Danio rerio

Alignment Length:	883	Identity:	228/883 - (25%)
Similarity:	353/883 - (39%)	Gaps:	278/883 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPW 149
            |.||||||||||||||||:..|||||..||||..:||.||||||:|||||||::|......:
Zfish    15 ERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLNSDE--- 76

  Fly   150 TREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQV 214
             :|....::|:|             |..|.: |::|:||.:.::.||..:|:||.||..:||:|.
Zfish    77 -KEEKEENELES-------------QLNGFY-LKALEGFLMVLSEDGDMVYLSENVSKSMGLTQF 126

  Fly   215 EMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGT 279
            ::||.|||::.|..||.|:.:.|                                         .
Zfish   127 DLTGHSIFEFSHPCDHEELREML-----------------------------------------V 150

  Fly   280 HGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSN--CNNGNN 340
            |.|.:.......|          :|||.:|||.|||.||  .:.||:.::......:  .:.|:.
Zfish   151 HRTGSKKTKEQNT----------ERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRVHEGSE 205

  Fly   341 ASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMF 405
            ||.:                            |...:||:..:|.:...:|.||..|:.|:...|
Zfish   206 ASED----------------------------SGFKEPPVTYLVLICEPIPHPSNIEVPLDSKTF 242

  Fly   406 VTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRL 470
            ::|...|::.::|:.|:::|:.|.|:||:|:|:|...||.|::.|.|:|.:|..|||..||.||:
Zfish   243 LSRHTLDMKFSYCDERITELMGYEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQATTGQYRM 307

  Fly   471 MNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEEGLGN 535
            :.|.||:.|::|.|||:.:.||:..|.|:|||||:|.....:::|...|....|.:::.|.....
Zfish   308 LAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAVEKESEETE 372

  Fly   536 DKSS------------------------------------GSPGGDASGEGNSHLSAGDMKL--- 561
            :|:|                                    ....|||....:.:.|..|::|
Zfish   373 EKTSELDILKLFKPESLNCSLESSTLYNKLKEEPEALTVLAPAAGDAIISLDFNNSDSDIQLLKE 437

  Fly   562 -------------------NSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDS---------- 597
                               .||.|.|:                 |:.:||.::..
Zfish   438 VPLYNDVMLPSSSEKLPLSLSPLTPSD-----------------SIPALTKLETGGEDFPFSSAS 485

  Fly   598 ---PTPLGVEIDSGVLPTTVATPVPAATP--PVQSTKRKRKTKASQHAEDQGQEQVISEQPL--- 654
               |.|......||:..:...:|:....|  |..|::.|........|.|...:...|.||:
Zfish   486 DRVPDPTNTPSTSGLGSSGPNSPMDYGFPVEPDISSEFKLDLVEKLFAIDTEAKTPFSTQPMEDL 550

  Fly   655 ------PKLPTMEQRDQQPRSRLPSIVDEQPSSA-ADSAVKDLEQAMSKHLPSPAAVVSVAPPNT 712
                  |.:|    .|...:.|:||.:|..||:. :.||:..|.|.:.....|||:
Zfish   551 DLEMLAPYIP----MDDDFQLRIPSPLDPLPSATHSVSAMSSLFQPLPSSPASPAS--------- 602

  Fly   713 DFSADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAPMPATALLRQLYANRESVIRATARQTP 777
              |..|.:||          |.||          :.|:|:   .||:::         .:|..:|
Zfish   603 --STSSTVKQ----------EASS----------RAPSPL---HLLQEV---------CSAPVSP 633

  Fly   778 TGVGPGVFYGDQQTGPL-PTPPGSESSYENQYLQLHSAASGGHPGGQK----TSADAFTNLVSTY 837
                   |.|.:...|: .:.|.|.|...|:.:.....|.......:|    ||......|.:..
Zfish   634 -------FSGSRDASPVRSSTPQSSSQLNNREMSPKMLAFQNIQRKRKLNEVTSLSEAVGLGALL 691

  Fly   838 GGYHSSIDYHNAMTPPSSVSPRDSNQPGKAAPVLASNG 875
            ....|:||                  |||.|.||...|
Zfish   692 HSVDSAID------------------PGKRAKVLEVKG 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	40/51 (78%)
		PAS	176..236	CDD:214512	24/59 (41%)
		PAS	180..>236	CDD:279347	23/55 (42%)
		PAS	403..505	CDD:238075	43/101 (43%)
		PAS_3	415..502	CDD:285623	37/86 (43%)
hif1ab	NP_001296971.1	HLH	14..74	CDD:238036	42/58 (72%)
		PAS	94..149	CDD:214512	23/54 (43%)
		PAS	239..338	CDD:238075	39/98 (40%)
		PAS_3	254..339	CDD:285623	37/84 (44%)
		HIF-1	543..574	CDD:288296	9/34 (26%)
		HIF-1a_CTAD	740..776	CDD:285931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592837
Domainoid	1	1.000	101	1.000	Domainoid score	I6867
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740