Protein Alignment trh and clockb

DIOPT Version :9

• Sequence 1: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_840080.2
• Gene: clockb / 352927
• ZFINID: ZDB-GENE-030408-2
• Length: 820
• Species: Danio rerio
• Alignment Length: 1031
• Identity: 209/1031 - (20%)
• Similarity: 359/1031 - (34%)
• Gaps: 341/1031 - (33%)

  Fly    82 GILEL-RKEKSRDAARS-----RRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRD 140
            |::|. .|:|::..:|:     ||.:.|....||..|||   ..|.::||::|::.:|.||:
Zfish    14 GLMEEDEKDKAKRVSRNKSEKKRRDQFNVLIKELGTMLP---GNTRKMDKSTILQKSIDYLR--- 72

  Fly   141 FSGHGDPPWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHI-LQSLDGFALAVAADGRFLYISET 204
                      :...::::.:|:.|::..........:.:.: |::||||.|.:..||..:||||:
Zfish    73 ----------KNKENAAQSESSDIKQDWKPPFLSNEEFSQLMLEALDGFFLVMLTDGYIIYISES 127

  Fly   205 VSIYLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPT 269
            |:..|.....::...::.:::...||.|:...|
Zfish   128 VTSLLEHLPSDLMDQNLLNFLPVVDHGEVYKAL-------------------------------- 160

  Fly   270 SGASDDGSGTHGTNNPDVAASMTQASTSGY-KGYDR-SFCVRMKSTLTKRGCHF--------KSS 324
                        ::.||:     :...|.| |..:: .||           ||.        |..
Zfish   161 ------------SSQPDI-----ENLNSDYLKSKNQMEFC-----------CHMLRGSVDPKKPP 197

  Fly   325 GYRASDATSNCNNGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYT-------FSHSRKSQPPL-- 380
            .|                   :.||..|:..|:|.:     ||.|       ..||  .||..
Zfish   198 VY-------------------EYVKFIGNFKSLVNM-----PQKTRNGLEGILQHS--LQPAFDD 236

  Fly   381 -LGMVALAIALPPPSVHEIRLEC------DMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSL 438
             |..:|......|..:.|:   |      :.|.:|.:.:.:....:.|...::.|.|.:::..|.
Zfish   237 QLCFIATVRLAKPQFIKEM---CMVEEPNEEFTSRHSLEWKFLLLDHRAPPIIGYMPFEVLGTSG 298

  Fly   439 YSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNY 503
            |...|.:|.:.|.|.|..|::.|:..:.|||.:.|...:.||||...:.....|:..:.|:|.:.
Zfish   299 YDYYHVDDLHSLAKCHEHLMQFGKGKSCYYRFLTKGQQWIWLQTNYYITYHQWNSRPEFIVCTHT 363

  Fly   504 VIS------NRENENMILDCCQLEPSPDSIKHEEGLGNDKSSGSPGGDASGEGNSHLSAGDMKLN 562
            |:|      .|..|      ..:|.||..      |..||.|||         .:.|:....|:.
Zfish   364 VVSYAEVRAERRRE------MGIEESPPE------LTADKISGS---------ETQLNNSLKKVL 407

  Fly   563 SPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKD-----SPTPLGVEIDSGVLPTT--------- 613
            ...:||     |....|:.:||.||.   |.|.|     :|:.|.:::.|...|.|
Zfish   408 ERFSDS-----RSPSTSSRSSHKSSH---TAISDNTCTSTPSKLHMDVSSSPRPATVDMISQRRS 464

  Fly   614 -VATPVPAATPPVQSTKRKRKTKASQHAEDQGQE-----------------QVISEQPLPKLPTM 660
             |:|...::....|:....:.::.:||.:.|.|:                 |.:.||       :
Zfish   465 SVSTQSMSSQNTTQTDSPVQISQQTQHQQQQPQQPQQVQPNALFSAQLNAMQHLKEQ-------L 522

  Fly   661 EQR-------------------DQQPRSRLPSIVDEQPSSAADSAVKDLEQAMSKH-----LPSP 701
            |||                   :|..|.:.|.::.:||:.....:|. |.|.....     :.:.
Zfish   523 EQRTRMIEANIQKQQEELRQIHEQLQRVQGPQMILQQPAQGGGPSVL-LPQVGGAQNNILGIGTQ 586

  Fly   702 AAVVSVAPPNTDFSADS-------LLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAPMPATALLR 759
            |:||::...|...:|.|       .|.|||..:.|..|.:||::...|..|.......||.|
Zfish   587 ASVVAIQGQNVTSTAHSGSAPQQQTLPQQQTPRSLQQNLQSSSVTQCGPVYNTMMISQPANA--- 648

  Fly   760 QLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTPPGSESSYENQYLQLHSAASGGHPGGQK 824
                   :|:     |.|:.:.|.:               |:::..|::           |.||:
Zfish   649 -------NVV-----QIPSNLAPKI---------------SQANAINRF-----------PAGQQ 675

  Fly   825 TSADAFTNLVSTYGGYHSSIDYHNAMTPPSSVSPRDSNQPGKAAPVLASNGGYDYAPDPLRGQYA 889
            ......|..::.           .|:..|:|:.         ...|:.:     |:|      :.
Zfish   676 LVTKIVTAPMAC-----------GAVMVPTSMF---------MGQVVTA-----YSP------FT 709

  Fly   890 TSSGDVVPATLPLKP-----QASYTATMHPSGSTTTEGGVTYSNLDQPQYFAPHSSFHLYHKGSP 949
            ...|.....||..:|     |.:..||:.     :.:.|.|..:..|.|.|.  .|..|.|...|
Zfish   710 QQQGQTQTITLQTQPTVPADQQTQAATLQ-----SQQQGATQQSTKQQQPFL--QSTRLLHGNQP 767

  Fly   950 ASGWYSTPSXVVDDQGQVPPSCQDQYHHHHHHH----------HHQDGSAGSSASQ 995
            ..  ....:..:..|....||.|.|.......|          .||..|| |:.||
Zfish   768 TQ--LILQAFPIQQQSTFTPSQQQQQQQQLKPHTQKPQKQTASSHQTDSA-SAQSQ 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	18/57 (32%)
		PAS	176..236	CDD:214512	17/60 (28%)
		PAS	180..>236	CDD:279347	17/56 (30%)
		PAS	403..505	CDD:238075	25/101 (25%)
		PAS_3	415..502	CDD:285623	23/86 (27%)
clockb	NP_840080.2	HLH	22..76	CDD:238036	17/69 (25%)
		PAS	99..160	CDD:214512	17/60 (28%)
		PAS_11	263..366	CDD:291273	26/102 (25%)
		PAS	264..362	CDD:238075	25/97 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910