DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and HIF1A

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001230013.1	Gene:	HIF1A / 3091	HGNCID:	4910	Length:	850	Species:	Homo sapiens

Alignment Length:	793	Identity:	213/793 - (26%)
Similarity:	337/793 - (42%)	Gaps:	207/793 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPW 149
            |.|||||||||||||.||:..|||||..||||..::|.|||||::|||||||::|.....||
Human    40 ERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD--- 101

  Fly   150 TREASSSSKLKSAAIRRSPAVDL---FEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGL 211
                                :|:   .:.......|::||||.:.:..||..:|||:.|:.|:||
Human   102 --------------------LDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGL 146

  Fly   212 SQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDG 276
            :|.|:||.|:||:.|..||.|:.:.|
Human   147 TQFELTGHSVFDFTHPCDHEEMREML--------------------------------------- 172

  Fly   277 SGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNGN 339
              ||  .|..|.....|.:       .|||.:|||.|||.||  .:.||:.::....|.:.:..:
Human   173 --TH--RNGLVKKGKEQNT-------QRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYD 226

  Fly   340 NASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDM 404
            ..||                     :||..:     .:||:..:|.:...:|.||..||.|:...
Human   227 TNSN---------------------QPQCGY-----KKPPMTCLVLICEPIPHPSNIEIPLDSKT 265

  Fly   405 FVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYR 469
            |::|.:.|::.::|:.|:::|:.|.||:|:.:|:|...||.|::.|.|:|.|:..||||.||.||
Human   266 FLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 330

  Fly   470 LMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDC----CQLEPSPDS---- 526
            ::.|.|||.|::|.|||:.:|||:..|.|:|||||:|.....::|...    |.|:|...|
Human   331 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKM 395

  Fly   527 ------IKHEEGLG-NDKSSGSPGG---DASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAA 581
                  ::.|:... .||....|..   .|...|::.:|. |...|..:||.:
Human   396 TQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISL-DFGSNDTETDDQ------------ 447

  Fly   582 ASHGSSMNSLTMIKD--SPTP----LGVEIDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHA 640
                 .:..:.:..|  .|:|    ..:.:....|| |..||.|..:....:..::...|...:.
Human   448 -----QLEEVPLYNDVMLPSPNEKLQNINLAMSPLP-TAETPKPLRSSADPALNQEVALKLEPNP 506

  Fly   641 EDQ----GQEQVISEQPLPKLPTMEQRDQQPRSRLPS---------IVDE--------------- 677
            |..    ...|:..:.|.|...:..|...:|.|  ||         :|:|
Human   507 ESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNS--PSEYCFYVDSDMVNEFKLELVEKLFAEDTE 569

  Fly   678 --QPSSAADSAVKDLEQAMSKHLP-------------SPAAVVSVAPPNTDFSADSLLKQQQQQQ 727
              .|.|..|:.: |||. ::.::|             ||....|.:|.:....:...:.||.|.|
Human   570 AKNPFSTQDTDL-DLEM-LAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQ 632

  Fly   728 QLDPNEKSST-----IQWIGTPYQQP-----PAPMPATALLRQLYANRESVIRATARQT--PTGV 780
            :...|..::|     ::.:.....:.     .:|.| |.:.::..:...|..|.|..:|  |...
Human   633 EPTANATTTTATTDELKTVTKDRMEDIKILIASPSP-THIHKETTSATSSPYRDTQSRTASPNRA 696

  Fly   781 GPGVFYGDQQTGP 793
            |.||....:::.|
Human   697 GKGVIEQTEKSHP 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	37/51 (73%)
		PAS	176..236	CDD:214512	25/59 (42%)
		PAS	180..>236	CDD:279347	25/55 (45%)
		PAS	403..505	CDD:238075	45/101 (45%)
		PAS_3	415..502	CDD:285623	39/86 (45%)
HIF1A	NP_001230013.1	HLH	39..92	CDD:238036	37/51 (73%)
		PAS	117..172	CDD:214512	25/54 (46%)
		PAS	263..362	CDD:238075	41/98 (42%)
		PAS_3	278..363	CDD:285623	39/84 (46%)
		HIF-1	575..605	CDD:288296	6/31 (19%)
		HIF-1a_CTAD	813..849	CDD:285931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740