Protein Alignment trh and Npas1

DIOPT Version :10

• Sequence 1: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_001100949.1
• Gene: Npas1 / 308387
• RGDID: 1310040
• Length: 595
• Species: Rattus norvegicus
• Alignment Length: 601
• Identity: 233/601 - (38%)
• Similarity: 313/601 - (52%)
• Gaps: 120/601 - (19%)

  Fly    57 PYNKMTG--HQQPPGAGMHAQQQPLEPGILELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAI 119
            |::.:.|  .:.|||..:.||           ||||||:|||.||||||.||:||||:||||.||
  Rat    25 PWDFLPGLMVKAPPGPCLQAQ-----------RKEKSRNAARWRRGKENLEFFELAKLLPLPGAI 78

  Fly   120 TSQLDKASIIRLTISYLKLRDFSGHGDPPWTREASSSSKLKSAAIRRSPAV--DLFEQHQGTHIL 182
            :||||||||:||:::||:||.|:..|.|||...|.......:...|.:.|:  ::||||.|.|||
  Rat    79 SSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAVGPPAGLAPGRRGAVALVSEVFEQHLGGHIL 143

  Fly   183 QSLDGFALAVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGG 247
            ||||||..|:..:|:||||||||||||||||||:||||:|||||..||||:.:||||...:.|
  Rat   144 QSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYIHPGDHSEVLEQLGLRAATTG-- 206

  Fly   248 GGGSSSSGGGGGGAGGGMASPT----SGASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCV 308
                               .||    |..|...|.:...:.|::.||.|:||.: ::..:|||.|
  Rat   207 -------------------PPTPPSVSSTSSSSSSSSLVDTPEIEASPTEASPA-FRVQERSFFV 251

  Fly   309 RMKSTLTKRGCHFKSSGYRASDATSNCNNGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHS 373
            ||||||||||.:.|:|||:....|.                             :||.:
  Rat   252 RMKSTLTKRGLNVKASGYKVIHVTG-----------------------------RLRAR------ 281

  Fly   374 RKSQPPLLGMVALAIALPPPSVHEIRLECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSL 438
                  .||:|||...|||..:.|:.|...|.|.|::..|.:..||.||||.:|..|.:||.:|.
  Rat   282 ------ALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDMGPSELVGRSC 340

  Fly   439 YSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNY 503
            |...|.:|..|:|:||.||::||||:|||||.:.::||:.|||:.|||..:.|:|.|.:::.|::
  Rat   341 YQFVHGQDVTRIRQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKSAGEHHVLWVSH 405

  Fly   504 VISNRENENMILDCCQLEPSPDSIKHEEGLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDS 568
            |:|:.|.....||..||   |..:..||       |.|||.:.:.|.    ...:.|...|....
  Rat   406 VLSHAEGGQTPLDAFQL---PAIVSQEE-------SSSPGPEPTKEE----PPVERKQTVPVEQD 456

  Fly   569 EGHSHRGRGR------SAAASHGSSMNSLTMIKDSPTPLGVEIDS----------GVLP---TTV 614
            :....:.||:      |.....||..:....:.|.|.|...|..|          .|||   ||.
  Rat   457 KDKDPQARGKRIKVEASPKEVRGSEDSGEEEVSDPPAPPRPEFTSVIRAGALKHDPVLPWGLTTP 521

  Fly   615 ATPVPAA-----TPPV 625
            ..|.||.     .|||
  Rat   522 GDPSPALLHAGFLPPV 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	bHLH-PAS_trachealess_like	83..152	CDD:381576	46/68 (68%)
		PAS	176..236	CDD:214512	44/59 (75%)
		PAS_3	415..502	CDD:430001	40/86 (47%)
Npas1	NP_001100949.1	bHLH-PAS_NPAS1_PASD5	43..116	CDD:381574	49/83 (59%)
		PAS	141..198	CDD:214512	42/56 (75%)
		PAS_3	317..388	CDD:430001	35/70 (50%)