DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trh and Npas1

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001100949.1	Gene:	Npas1 / 308387	RGDID:	1310040	Length:	595	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	233/601 - (38%)
Similarity:	313/601 - (52%)	Gaps:	120/601 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PYNKMTG--HQQPPGAGMHAQQQPLEPGILELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAI 119
            |::.:.|  .:.|||..:.||           ||||||:|||.||||||.||:||||:||||.||
  Rat    25 PWDFLPGLMVKAPPGPCLQAQ-----------RKEKSRNAARWRRGKENLEFFELAKLLPLPGAI 78

  Fly   120 TSQLDKASIIRLTISYLKLRDFSGHGDPPWTREASSSSKLKSAAIRRSPAV--DLFEQHQGTHIL 182
            :||||||||:||:::||:||.|:..|.|||...|.......:...|.:.|:  ::||||.|.|||
  Rat    79 SSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAVGPPAGLAPGRRGAVALVSEVFEQHLGGHIL 143

  Fly   183 QSLDGFALAVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGG 247
            ||||||..|:..:|:||||||||||||||||||:||||:|||||..||||:.:||||...:.|
  Rat   144 QSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYIHPGDHSEVLEQLGLRAATTG-- 206

  Fly   248 GGGSSSSGGGGGGAGGGMASPT----SGASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCV 308
                               .||    |..|...|.:...:.|::.||.|:||.: ::..:|||.|
  Rat   207 -------------------PPTPPSVSSTSSSSSSSSLVDTPEIEASPTEASPA-FRVQERSFFV 251

  Fly   309 RMKSTLTKRGCHFKSSGYRASDATSNCNNGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHS 373
            ||||||||||.:.|:|||:....|.                             :||.:
  Rat   252 RMKSTLTKRGLNVKASGYKVIHVTG-----------------------------RLRAR------ 281

  Fly   374 RKSQPPLLGMVALAIALPPPSVHEIRLECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSL 438
                  .||:|||...|||..:.|:.|...|.|.|::..|.:..||.||||.:|..|.:||.:|.
  Rat   282 ------ALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDMGPSELVGRSC 340

  Fly   439 YSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNY 503
            |...|.:|..|:|:||.||::||||:|||||.:.::||:.|||:.|||..:.|:|.|.:::.|::
  Rat   341 YQFVHGQDVTRIRQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKSAGEHHVLWVSH 405

  Fly   504 VISNRENENMILDCCQLEPSPDSIKHEEGLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDS 568
            |:|:.|.....||..||   |..:..||       |.|||.:.:.|.    ...:.|...|....
  Rat   406 VLSHAEGGQTPLDAFQL---PAIVSQEE-------SSSPGPEPTKEE----PPVERKQTVPVEQD 456

  Fly   569 EGHSHRGRGR------SAAASHGSSMNSLTMIKDSPTPLGVEIDS----------GVLP---TTV 614
            :....:.||:      |.....||..:....:.|.|.|...|..|          .|||   ||.
  Rat   457 KDKDPQARGKRIKVEASPKEVRGSEDSGEEEVSDPPAPPRPEFTSVIRAGALKHDPVLPWGLTTP 521

  Fly   615 ATPVPAA-----TPPV 625
            ..|.||.     .|||
  Rat   522 GDPSPALLHAGFLPPV 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	38/51 (75%)
		PAS	176..236	CDD:214512	44/59 (75%)
		PAS	180..>236	CDD:279347	42/55 (76%)
		PAS	403..505	CDD:238075	45/101 (45%)
		PAS_3	415..502	CDD:285623	40/86 (47%)
Npas1	NP_001100949.1	bHLH-PAS_NPAS1_PASD5	43..116	CDD:381574	49/83 (59%)
		PAS	141..198	CDD:214512	42/56 (75%)
		PAS_3	317..388	CDD:369881	35/70 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351079
Domainoid	1	1.000	95	1.000	Domainoid score	I7250
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2273
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		oto97633
orthoMCL	1	0.900	-	-		OOG6_107023
Panther	1	1.100	-	-	LDO	PTHR23043
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760