DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and Epas1

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_038967774.1	Gene:	Epas1 / 29452	RGDID:	68404	Length:	885	Species:	Rattus norvegicus

Alignment Length:	992	Identity:	254/992 - (25%)
Similarity:	386/992 - (38%)	Gaps:	277/992 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPW 149
            ||||||||||||.||.||...|||||..||||.:::|.||||||:||.||:|:
  Rat    24 ELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLR------------ 76

  Fly   150 TREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQV 214
                  :.||.|:....:.:....:|......|::|:||...|..||..:::||.:|.::||:||
  Rat    77 ------THKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQV 135

  Fly   215 EMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGT 279
            |:||.||||:.|..||.||.:.|.|...||
  Rat   136 ELTGHSIFDFTHPCDHEEIRENLTLKTGSG----------------------------------- 165

  Fly   280 HGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNGNNAS 342
            .|..|.|::.             :|.|.:|||.|:|.||  .:.||:.::....|......||..
  Rat   166 FGKKNKDMST-------------ERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNNCP 217

  Fly   343 NNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMFVT 407
                    |.|:      ||..:           :|.|..::.:...:..||..:|.|:...|::
  Rat   218 --------PHSS------LCGYK-----------EPLLSCLIIMCEPIQHPSHMDIPLDSKTFLS 257

  Fly   408 RVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMN 472
            |.:.|::..:|:.|:.:|:.|.||:|:.:|.|...||.|:..:.|||.:|..||||::|.||::.
  Rat   258 RHSMDMKFTYCDDRILELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLA 322

  Fly   473 KSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMIL---------------------- 515
            |.|||.||:|..|||.:.:|...|.|:|||||:|..|..:::.
  Rat   323 KHGGYVWLETQGTVVYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDS 387

  Fly   516 ----------------------DCCQLEPSPDS--IKHEEGLGN-DKSSG------SPGGDASGE 549
                                  |..||.|:|..  |..:.|..| |:||.      .||...:.|
  Rat   388 SDDVALSEKSNYLFTKLKEEPEDLAQLAPTPGDAIISLDFGSQNFDESSTYGKAILPPGQPWATE 452

  Fly   550 GNSHLSAGDMK----LNSPKTDSEGHSHRGRGRSAAASHGSS----MNSL-------------TM 593
            ..||.:..:.:    ...|:..|.|::......|::.|..||    .:||             .|
  Rat   453 LRSHSAQSESRSLPAFTVPQAGSPGNATPSATSSSSCSTPSSPEDYYSSLENHLKIEVIEKLFAM 517

  Fly   594 IKDSPTPLGVEIDSGVLP-TTVATPVPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPL-PK 656
            ..::......:.|...|. .|:|..:|                  ...||.....:..|:|| |:
  Rat   518 DTEAKDQCSTQTDFNELDLETLAPYIP------------------MDGEDFQLSPICPEEPLVPE 564

  Fly   657 LPTMEQRDQQPRSRLPSIVDEQPSSAA------DSAVKDLE--QAMSKHLPS-----PAAVVSVA 708
            .|  :...|...|.:.||.......|:      |...:.||  :..|:|.|.     .|......
  Rat   565 SP--QPNPQHCFSTMSSIFQPLTPGASQGTFFLDKYPQQLESRKTESEHWPMSTIFFDAGSKGSL 627

  Fly   709 PP-----NTDFSADSLLKQQQQQQQLDPNEKSSTIQW--------------IGTPYQQPPAPMP- 753
            ||     :|..|  |:..:...|...||.......:|              :||...:||:..|
  Rat   628 PPCCGQASTPLS--SMGGRSNTQWPPDPPLHFGPTKWSVGNQSAEPLGPLPLGTSQLEPPSTPPH 690

  Fly   754 -----------------------ATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLP 795
                                   ..||..:|...|:......|.|..:|       ||
  Rat   691 VSMFKMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLDYEEPAFQDTSG-------GD------- 741

  Fly   796 TPPGSESSYENQYLQLHSAASGGHP-GGQKT-----SADAFTNLVSTYGGYHSSIDYHNAMTPPS 854
             |||:.||: ..:.::.|...|..| ...||     :.|.||.  .:..|....:.:.....|||
  Rat   742 -PPGTSSSH-LMWKRMKSLMGGTCPLMPDKTVSASMAPDEFTQ--KSMRGLGQPLRHLPPSQPPS 802

  Fly   855 SVSPRDSNQPGKAAPVLASNGGYDYAPDPLRGQYATSSGDVVPATLP-LKPQAS-YTATMH---P 914
            :.||.::.:.| ..|...::...||:|...:.....:|..:.|:..| |.|:.: |...::   |
  Rat   803 TRSPGENAKSG-FPPQCYASPFQDYSPPGAQKGSGVASRLLGPSFEPYLLPELTRYDCEVNVPVP 866

  Fly   915 SGSTTTEGGVTYSNLDQ 931
            ..||..:|......|||
  Rat   867 GSSTLLQGRDLLRALDQ 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	36/51 (71%)
		PAS	176..236	CDD:214512	26/59 (44%)
		PAS	180..>236	CDD:279347	26/55 (47%)
		PAS	403..505	CDD:238075	43/101 (43%)
		PAS_3	415..502	CDD:285623	37/86 (43%)
Epas1	XP_038967774.1	bHLH-PAS_HIF2a_PASD2	20..85	CDD:381571	40/78 (51%)
		PAS	97..158	CDD:214512	26/60 (43%)
		PAS_3	265..352	CDD:369881	37/86 (43%)
		HIF-1	527..559	CDD:402842	7/49 (14%)
		HIF-1a_CTAD	849..884	CDD:400914	10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351078
Domainoid	1	1.000	98	1.000	Domainoid score	I7013
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840