DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and Sim2

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_006523029.1	Gene:	Sim2 / 20465	MGIID:	98307	Length:	661	Species:	Mus musculus

Alignment Length:	811	Identity:	243/811 - (29%)
Similarity:	353/811 - (43%)	Gaps:	241/811 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLR------DFSGHGD 146
            ||||::||::||.|||.|||||||:||||:|||||||||||||||.||||:|      :.:|.||
Mouse     2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGEAAGLGD 66

  Fly   147 PPWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGL 211
             .|.:.:            |:..:|...:..|:|:||:||||...||:||:.:|||||.|::|||
Mouse    67 -AWGQPS------------RTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGL 118

  Fly   212 SQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDG 276
            ||||:||:||::|||.:||.|:...|
Mouse   119 SQVELTGNSIYEYIHPSDHDEMTAVL--------------------------------------- 144

  Fly   277 SGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCNNGNNA 341
                 |.:|.:...:.|.    |: .:|||.:|||..|.||......|||:    ..:|
Mouse   145 -----TAHPPLHHHLLQE----YE-IERSFFLRMKCVLAKRNAGLTCSGYK----VIHC------ 189

  Fly   342 SNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHS-RKSQPPLLGMVALAIALPPPSVHEIRLECDMF 405
                       |.|      .|:| ||....| ..|...::|:||:..:|||.::.||:|..:||
Mouse   190 -----------SGY------LKIR-QYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMF 236

  Fly   406 VTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRL 470
            :.|.:.||::...:.||::|..|.|:||:.|:||...|..|...||.:|..|:.||||.|.||||
Mouse   237 MFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYRL 301

  Fly   471 MNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEEGLGN 535
            ::|.||:.|:|:.||||.:::::....|:.||||:::.|.:.:.|...|:..|    |.:|....
Mouse   302 LSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVSTS----KSQESWRT 362

  Fly   536 DKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDSPTP 600
            ..|:                       |.:|           |.:|....:.|.  |.::.:|.|
Mouse   363 TLST-----------------------SQET-----------RKSAKPKNTKMK--TKLRTNPYP 391

  Fly   601 ----LGVEID----SGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAE---------------- 641
                ...::|    |.|.....:.|..|..||.|..          |:|
Mouse   392 PQQYSSFQMDKLECSQVGNWRTSPPTNAVAPPEQQL----------HSEASDLLYGPPYSLPFSY 446

  Fly   642 DQGQEQVISEQPLPKLPTMEQRDQQPR-----------SRLPSIVDEQ--------PSSAADSAV 687
            ..|...:.|.....|.|.:..:..||:           |.||:..:.|        |||:  |..
Mouse   447 HYGHFPLDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHCANSLVPSSS--SPA 509

  Fly   688 KDLEQAMSKHLPSP--AAVVSVAPPNTDFSADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPA 750
            |:|.:      |||  ||...:.|   ::.|.|...::..:....|:..|.      ..|::.||
Mouse   510 KNLSE------PSPVNAARHGLVP---NYEAPSAAARRFCEDPAPPSFPSC------GHYREEPA 559

  Fly   751 PMPATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTP------PGSESSYENQYL 809
            ..||.| .||  |:|::...|.||..|....|          |.|.|      |....:|.....
Mouse   560 LGPAKA-PRQ--ASRDAARLALARAPPECCAP----------PAPEPQAPAQLPFVLLNYHRVLA 611

  Fly   810 Q---LHSAASGG----------HPGGQKTSA 827
            :   |.|||.|.          |||....||
Mouse   612 RRGPLGSAAPGAPEAAGSLRPRHPGPVAASA 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	39/48 (81%)
		PAS	176..236	CDD:214512	35/59 (59%)
		PAS	180..>236	CDD:279347	34/55 (62%)
		PAS	403..505	CDD:238075	43/101 (43%)
		PAS_3	415..502	CDD:285623	35/86 (41%)
Sim2	XP_006523029.1	bHLH_SF	1..78	CDD:381792	47/88 (53%)
		PAS	83..144	CDD:214512	35/60 (58%)
		PAS_3	247..333	CDD:369881	35/85 (41%)
		SIM_C	363..654	CDD:369005	75/356 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.770