DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and hif-1

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001023891.2	Gene:	hif-1 / 180359	WormBaseID:	WBGene00001851	Length:	721	Species:	Caenorhabditis elegans

Alignment Length:	943	Identity:	185/943 - (19%)
Similarity:	316/943 - (33%)	Gaps:	328/943 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LELRKEKSRDAARSRRGKENYEFYELAKMLPL-PAAITSQLDKASIIRLTISYLKLRDFSGH--- 144
            :|.|:|.||.|||.||.||:..|.:|...:|: .....:.||:.:::|:..:..:||..:|:
Worm     9 MERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLE 73

  Fly   145 -------GDPPWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYIS 202
                   .:..||.:.                           |.:.||||.:.|.:|...||::
Worm    74 NNLDNEITNEVWTEDT---------------------------IAECLDGFVMIVDSDSSILYVT 111

  Fly   203 ETVSIYLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMAS 267
            |:|::||||:|.::||.::.|::|.:|:.|...|                          ..|..
Worm   112 ESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQ--------------------------SKMLH 150

  Fly   268 PTSGASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG-C-HFKSSGYR--- 327
            ...|...|.:|.                         :..:|||:.::.|| | :.||:.|:
Worm   151 KPRGEDTDTTGI-------------------------NMVLRMKTVISPRGRCLNLKSALYKSVS 190

  Fly   328 ----------------------ASDATSNCNNGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTF 370
                                  |...|:|.    |||...|..::|
Worm   191 FLVHSKVSTGGHVSFMQGITIPAGQGTTNA----NASAMTKYTESP------------------- 232

  Fly   371 SHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVN 435
                      :|                     .|.||...|:|:.....:.:.:|....:.|:.
Worm   233 ----------MG---------------------AFTTRHTCDMRITFVSDKFNYILKSELKTLMG 266

  Fly   436 KSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMNKSGGYTWLQTCATVVC-STKNADEQNII 499
            .|.|.|.|..|...:.||..:|..||.:.|.||||:..:....|:||.||.:. :||....|.:|
Worm   267 TSFYELVHPADMMIVSKSMKELFAKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVI 331

  Fly   500 CVNYVISNRENENMILDCCQLEPSPDSIKHEEGLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSP 564
            ||:||:..:..|..::.|      .||:              |.|              |:::..
Worm   332 CVHYVLGIQGAEESLVVC------TDSM--------------PAG--------------MQVDIK 362

  Fly   565 KTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDSP--------TPLGVEIDSGVLPTTVATPVPAA 621
            |...:...:.||                    .|        ||| :|.:...  .||..||...
Worm   363 KEVDDTRDYIGR--------------------QPEIVECVDFTPL-IEPEDPF--DTVIEPVVGG 404

  Fly   622 TPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPKLPTMEQRDQQPRSRLPSIVDEQPSSAADSA 686
            ..||    ::....|.:::.|...:.:..:||....|...:...:.|:..||      :..:..|
Worm   405 EEPV----KQADMGARKNSYDDVLQWLFRDQPSSPPPARYRSADRFRTTEPS------NFGSALA 459

  Fly   687 VKDLEQAMSKHLPSPAAVVSVAPPNTDFSADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAP 751
            ..|...:.|:          .:.|.|.:.      ::.|.|.......|||......|:....:|
Worm   460 SPDFMDSSSR----------TSRPKTSYG------RRAQSQGSRTTGSSSTSASATLPHSANYSP 508

  Fly   752 MPATALLRQLYANRESVIRATARQTPT-GVGPG-VFYGDQQTGPLPTPPGSESSYENQYLQLHSA 814
            :            .|.:.:......|: .:..| |.|||.::......| |:||      :..||
Worm   509 L------------AEGISQCGLNSPPSCSIKSGQVVYGDARSMGRSCDP-SDSS------RRFSA 554

  Fly   815 ASGGHPGGQKTSADAFTNLVSTYG--------GYHSSIDYHNAMTPPSSVSPRDSNQP--GKAAP 869
            .|         .:|.. |:.||.|        ...|::.:.:::    :::.|..:.|  ....|
Worm   555 LS---------PSDTL-NVSSTRGINPVIGSNDVFSTMPFADSI----AIAERIDSSPTLTSGEP 605

  Fly   870 VLASNGGYDYAPD-----PLRGQYATSSGDV-----------VPATLPLKPQASYTATMH----P 914
            :|..:..:: .||     |....|.....|.           :|...|..|||.....:|    |
Worm   606 ILCDDLQWE-EPDLSCLAPFVDTYDMMQMDEGLPPELQALYDLPDFTPAVPQAPAARPVHIDRSP 669

  Fly   915 SGSTTTEGGVTYSNLDQPQYFAPHSSFHLYHKG 947
            ......:.|.:..:....|::.|......|.:|
Worm   670 PAKRMHQSGPSDLDFMYTQHYQPFQQDETYWQG 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	18/52 (35%)
		PAS	176..236	CDD:214512	22/59 (37%)
		PAS	180..>236	CDD:279347	22/55 (40%)
		PAS	403..505	CDD:238075	34/102 (33%)
		PAS_3	415..502	CDD:285623	27/87 (31%)
hif-1	NP_001023891.2	HLH	10..66	CDD:238036	19/55 (35%)
		PAS	94..>145	CDD:238075	21/50 (42%)
		PAS	233..>312	CDD:238075	24/99 (24%)
		PAS_11	236..338	CDD:291273	35/101 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158859
Domainoid	1	1.000	51	1.000	Domainoid score	I7753
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm14250
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840