DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trh and Epas1

DIOPT Version :9

Sequence 1:NP_001261207.1 Gene:trh / 38065 FlyBaseID:FBgn0262139 Length:1022 Species:Drosophila melanogaster
Sequence 2:NP_034267.3 Gene:Epas1 / 13819 MGIID:109169 Length:874 Species:Mus musculus


Alignment Length:1000 Identity:247/1000 - (24%)
Similarity:372/1000 - (37%) Gaps:293/1000 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPW 149
            ||||||||||||.||.||...|||||..||||.:::|.||||||:||.||:|:            
Mouse    13 ELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLR------------ 65

  Fly   150 TREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQV 214
                  :.||.|:....:.:....:|......|::|:||...|..||..:::||.:|.::||:||
Mouse    66 ------THKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQV 124

  Fly   215 EMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGT 279
            |:||.||||:.|..||.||.:.|.|.                                  :||| 
Mouse   125 ELTGHSIFDFTHPCDHEEIRENLTLK----------------------------------NGSG- 154

  Fly   280 HGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNGNNAS 342
            .|..:.||:.             :|.|.:|||.|:|.||  .:.||:.::....|......||..
Mouse   155 FGKKSKDVST-------------ERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNNCP 206

  Fly   343 NNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLG-MVALAIALPPPSVHEIRLECDMFV 406
                    |.|:      ||            .|:.|||. ::.:...:..||..:|.|:...|:
Mouse   207 --------PHSS------LC------------GSKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245

  Fly   407 TRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLM 471
            :|.:.|::..:|:.|:.:|:.|.||:|:.:|.|...||.|:..:.|||.:|..||||::|.||::
Mouse   246 SRHSMDMKFTYCDDRILELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRML 310

  Fly   472 NKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLE--------------P 522
            .|.|||.||:|..||:.:.:|...|.|:|||||:|..|..:::....|.|              .
Mouse   311 AKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFD 375

  Fly   523 SPDSIKHEE-------GLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGR-- 578
            |.|.:...|       .|..:....:......|:....|..|....:.|  .:.|.:....|:  
Mouse   376 SSDDVAVTEKSNYLFTKLKEEPEELAQLAPTPGDAIISLDFGSQNFDEP--SAYGKAILPPGQPW 438

  Fly   579 -SAAASHGSSMNSLTMIKDSPTPLGVEIDSGVLP--TTVATPVPAATPPVQSTKRKRKTKASQHA 640
             |...||.:                 :.:||.||  |......|..|.|..|:.....|.:|...
Mouse   439 VSGLRSHSA-----------------QSESGSLPAFTVPQADTPGNTTPSASSSSSCSTPSSPED 486

  Fly   641 EDQGQEQVISEQPLPKLPTMEQRDQQPRSR--------LPSIVDEQPSSAADSAVKDL--EQAMS 695
            .....|..:..:.:.||..|:...:.|.|.        |.::....|....|..:..:  |:.:.
Mouse   487 YYSSLENPLKIEVIEKLFAMDTEPRDPGSTQTDFSELDLETLAPYIPMDGEDFQLSPICPEEPLM 551

  Fly   696 KHLPSP------AAVVSVAPPNTDFSADSLLKQQQQQQQLDPNEKSSTIQW-------------- 740
            ...|.|      :.:.|:..|.|..:........:..|||: :.|:.:..|              
Mouse   552 PESPQPTPQHCFSTMTSIFQPLTPGATHGPFFLDKYPQQLE-SRKTESEHWPMSSIFFDAGSKGS 615

  Fly   741 -------IGTPY---------QQPPAPMPATALLRQLYANRESVIRATARQTPTGVGPGVF-YGD 788
                   ..||.         |.||.|                         |...||..: .||
Mouse   616 LSPCCGQASTPLSSMGGRSNTQWPPDP-------------------------PLHFGPTKWPVGD 655

  Fly   789 QQT---GPLPT------PPGS--------------------------------------ESSYEN 806
            |..   |.||.      ||.:                                      :..||.
Mouse   656 QSAESLGALPVGSSQLEPPSAPPHVSMFKMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLEYEE 720

  Fly   807 QYLQLHSAASGGHPGGQKTSADAFTNLVSTYGGY-----HSSIDYHNA----------------- 849
            |..|   ..|||.|.|..:|...:..:.|..||.     ..:|..:.|                 
Mouse   721 QAFQ---DTSGGDPPGTSSSHLMWKRMKSLMGGTCPLMPDKTISANMAPDEFTQKSMRGLGQPLR 782

  Fly   850 -MTPPSSVSPRDSNQPGKAA--PVLASNGGYDYAPDPLRGQYATSSGDVVPATLP-LKPQAS-YT 909
             :.||...|.|.|.:..|..  |...::...||.|...:.....:|..:.|:..| |.|:.: |.
Mouse   783 HLPPPQPPSTRSSGENAKTGFPPQCYASQFQDYGPPGAQKVSGVASRLLGPSFEPYLLPELTRYD 847

  Fly   910 ATMH---PSGSTTTEGGVTYSNLDQ 931
            ..::   |..||..:|......|||
Mouse   848 CEVNVPVPGSSTLLQGRDLLRALDQ 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trhNP_001261207.1 HLH 85..137 CDD:238036 36/51 (71%)
PAS 176..236 CDD:214512 26/59 (44%)
PAS 180..>236 CDD:279347 26/55 (47%)
PAS 403..505 CDD:238075 42/101 (42%)
PAS_3 415..502 CDD:285623 36/86 (42%)
Epas1NP_034267.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 9/9 (100%)
HLH 12..68 CDD:238036 37/72 (51%)
DNA-binding. /evidence=ECO:0000269|PubMed:26245371 26..53 15/26 (58%)
PAS 86..147 CDD:214512 26/60 (43%)
Required for heterodimer formation with ARNT. /evidence=ECO:0000269|PubMed:26245371 171..192 9/20 (45%)
PAS 241..340 CDD:238075 38/98 (39%)
PAS_3 254..341 CDD:285623 36/86 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..489 14/67 (21%)
NTAD 495..541 8/45 (18%)
HIF-1 516..548 CDD:288296 3/31 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..803 6/25 (24%)
CTAD 834..874 10/38 (26%)
HIF-1a_CTAD 837..873 CDD:285931 10/35 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847524
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3558
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000232
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.740

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