Protein Alignment trh and sim1

DIOPT Version :10

• Sequence 1: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: XP_004914602.1
• Gene: sim1 / 100486719
• XenbaseID: XB-GENE-485816
• Length: 763
• Species: Xenopus tropicalis
• Alignment Length: 907
• Identity: 247/907 - (27%)
• Similarity: 359/907 - (39%)
• Gaps: 265/907 - (29%)

  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLR--------DFSGH 144
            ||||::|||:||.|||.|||||||:||||:|||||||||||||||.||||:|        :..||
 Frog     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGH 66

  Fly   145 GDPPWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYL 209
            ...|.|                   :|...:..|:|:||:||||...||.||:.:|||||.|::|
 Frog    67 TSRPST-------------------LDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHL 112

  Fly   210 GLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASD 274
            ||||||:||:||::|||.|||.|:...|                                  .:.
 Frog   113 GLSQVELTGNSIYEYIHPADHDEMTAVL----------------------------------TAH 143

  Fly   275 DGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCNNGN 339
            ....:|.....::               :|||.:|||..|.||.......||:    ..:|
 Frog   144 QPYHSHFVQEYEI---------------ERSFFLRMKCVLAKRNAGLTCGGYK----VIHC---- 185

  Fly   340 NASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPL------LGMVALAIALPPPSVHEI 398
                         |.|      .|:| ||:...|     |.      :|:||:..:|||.:|.||
 Frog   186 -------------SGY------LKIR-QYSLDMS-----PFDGCYQNVGLVAVGHSLPPSAVTEI 225

  Fly   399 RLECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQV 463
            :|..:||:.|.:.|:::...:.||::|..|.|:||:.|:||...|..|...||.:|..|:.||||
 Frog   226 KLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQV 290

  Fly   464 LTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSP---- 524
            .|.|||.:.|.||:.|:|:.||:|.:::::....|:.||||:::.|.:.:.|...|:...|
 Frog   291 TTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVTTKPPFSY 355

  Fly   525 --------DSIKHEEG-LGNDKSSG--SPGGDASG------EGNSHLSAGDMKLNSPKTDS---- 568
                    ||.|..:. |.|.||..  ||....||      |.:.....|    .||.||:
 Frog   356 TSSNPTINDSRKSSKARLSNTKSKSRTSPYPQYSGFHTERSESDHESQWG----GSPLTDTASPQ 416

  Fly   569 --------EGHSH------RGRGRSAAASHGSSMNSLTMIKD----SPTPLGVEIDSG------- 608
                    ..|.|      |.....:....|.|::...:..|    |.:..|...::|
 Frog   417 LLDPIERPSSHQHDVSCAYRQYPDRSGLCFGFSIDHSRLSDDRHHHSQSCEGGRCEAGRYFLGSP 481

  Fly   609 ------------VLPTTVATP-----VPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPK 656
                        |||....:|     ..|..|.:.|..|       .|.....:|..:...|.|.
 Frog   482 QTGRETWWGSRSVLPVPKTSPDGKDIYEATMPHIASGHR-------AHGRSHWEEDSVVSSPDPG 539

  Fly   657 LPTME----QRDQQPRSRLPSIVDEQPSS------AADSAVKDLEQAMSKHLPSP---------- 701
            ..:..    :.||...|.      .:||.      |....:|:.|..:....|||
 Frog   540 SASESGDRYRTDQYQNSH------HEPSKIETLIRATQQMIKEEESRIQLRKPSPDQLTTINGAG 598

  Fly   702 ---------------AAVVSVAPPNTDFS-ADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPA 750
                           ..||...||.::.| .|.:  ||:..:.|.|.:..         |:..|
 Frog   599 KRNSVCFANFHQPQLTGVVCRGPPLSNSSPCDHV--QQRDGKILSPRDHE---------YENSP- 651

  Fly   751 PMPATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTPPGSESSYEN--QYLQLHS 813
                .||.|....|.:.|.:::..     :.....:.:....|......|.:.|.:  ||...|:
 Frog   652 ----NALSRMSSPNSDRVSKSSVT-----IAKDYLHANLSPSPAMDHSASPNYYSSHRQYFDKHT 707

  Fly   814 AASGGHPGGQKTSADAFTNLVSTYGGYHSSIDYHNAMTPPSSVSPRDSNQPGKAAPVLASNG 875
            ....|:.......:::..|......|.|..:..|..|       .:||.|..|...|:.|||
 Frog   708 YTFTGYALEHLYDSESIRNYSLGCNGTHFDVTSHLRM-------QQDSAQVHKGTSVIISNG 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	bHLH-PAS_trachealess_like	83..152	CDD:381576	47/71 (66%)
		PAS	176..236	CDD:214512	36/59 (61%)
		PAS_3	415..502	CDD:430001	33/86 (38%)
sim1	XP_004914602.1	bHLH-PAS_SIM1	1..71	CDD:381581	45/68 (66%)
		PAS	88..>158	CDD:238075	34/118 (29%)
		PAS_3	243..329	CDD:430001	33/85 (39%)
		SIM_C	357..668	CDD:461963	66/343 (19%)