DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trh and sim1

DIOPT Version :9

Sequence 1:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_004914602.1	Gene:	sim1 / 100486719	XenbaseID:	XB-GENE-485816	Length:	763	Species:	Xenopus tropicalis

Alignment Length:	907	Identity:	247/907 - (27%)
Similarity:	359/907 - (39%)	Gaps:	265/907 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLR--------DFSGH 144
            ||||::|||:||.|||.|||||||:||||:|||||||||||||||.||||:|        :..||
Frog     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGH 66

  Fly   145 GDPPWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYL 209
            ...|.|                   :|...:..|:|:||:||||...||.||:.:|||||.|::|
Frog    67 TSRPST-------------------LDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHL 112

  Fly   210 GLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASD 274
            ||||||:||:||::|||.|||.|:...|                                  .:.
Frog   113 GLSQVELTGNSIYEYIHPADHDEMTAVL----------------------------------TAH 143

  Fly   275 DGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCNNGN 339
            ....:|.....::               :|||.:|||..|.||.......||:    ..:|
Frog   144 QPYHSHFVQEYEI---------------ERSFFLRMKCVLAKRNAGLTCGGYK----VIHC---- 185

  Fly   340 NASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPL------LGMVALAIALPPPSVHEI 398
                         |.|      .|:| ||:...|     |.      :|:||:..:|||.:|.||
Frog   186 -------------SGY------LKIR-QYSLDMS-----PFDGCYQNVGLVAVGHSLPPSAVTEI 225

  Fly   399 RLECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQV 463
            :|..:||:.|.:.|:::...:.||::|..|.|:||:.|:||...|..|...||.:|..|:.||||
Frog   226 KLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQV 290

  Fly   464 LTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSP---- 524
            .|.|||.:.|.||:.|:|:.||:|.:::::....|:.||||:::.|.:.:.|...|:...|
Frog   291 TTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVTTKPPFSY 355

  Fly   525 --------DSIKHEEG-LGNDKSSG--SPGGDASG------EGNSHLSAGDMKLNSPKTDS---- 568
                    ||.|..:. |.|.||..  ||....||      |.:.....|    .||.||:
Frog   356 TSSNPTINDSRKSSKARLSNTKSKSRTSPYPQYSGFHTERSESDHESQWG----GSPLTDTASPQ 416

  Fly   569 --------EGHSH------RGRGRSAAASHGSSMNSLTMIKD----SPTPLGVEIDSG------- 608
                    ..|.|      |.....:....|.|::...:..|    |.:..|...::|
Frog   417 LLDPIERPSSHQHDVSCAYRQYPDRSGLCFGFSIDHSRLSDDRHHHSQSCEGGRCEAGRYFLGSP 481

  Fly   609 ------------VLPTTVATP-----VPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPK 656
                        |||....:|     ..|..|.:.|..|       .|.....:|..:...|.|.
Frog   482 QTGRETWWGSRSVLPVPKTSPDGKDIYEATMPHIASGHR-------AHGRSHWEEDSVVSSPDPG 539

  Fly   657 LPTME----QRDQQPRSRLPSIVDEQPSS------AADSAVKDLEQAMSKHLPSP---------- 701
            ..:..    :.||...|.      .:||.      |....:|:.|..:....|||
Frog   540 SASESGDRYRTDQYQNSH------HEPSKIETLIRATQQMIKEEESRIQLRKPSPDQLTTINGAG 598

  Fly   702 ---------------AAVVSVAPPNTDFS-ADSLLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPA 750
                           ..||...||.::.| .|.:  ||:..:.|.|.:..         |:..|
Frog   599 KRNSVCFANFHQPQLTGVVCRGPPLSNSSPCDHV--QQRDGKILSPRDHE---------YENSP- 651

  Fly   751 PMPATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTPPGSESSYEN--QYLQLHS 813
                .||.|....|.:.|.:::..     :.....:.:....|......|.:.|.:  ||...|:
Frog   652 ----NALSRMSSPNSDRVSKSSVT-----IAKDYLHANLSPSPAMDHSASPNYYSSHRQYFDKHT 707

  Fly   814 AASGGHPGGQKTSADAFTNLVSTYGGYHSSIDYHNAMTPPSSVSPRDSNQPGKAAPVLASNG 875
            ....|:.......:::..|......|.|..:..|..|       .:||.|..|...|:.|||
Frog   708 YTFTGYALEHLYDSESIRNYSLGCNGTHFDVTSHLRM-------QQDSAQVHKGTSVIISNG 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trh	NP_001261207.1	HLH	85..137	CDD:238036	40/48 (83%)
		PAS	176..236	CDD:214512	36/59 (61%)
		PAS	180..>236	CDD:279347	35/55 (64%)
		PAS	403..505	CDD:238075	40/101 (40%)
		PAS_3	415..502	CDD:285623	33/86 (38%)
sim1	XP_004914602.1	bHLH-PAS_SIM1	1..71	CDD:381581	45/68 (66%)
		PAS	88..>158	CDD:238075	34/118 (29%)
		PAS_3	243..329	CDD:369881	33/85 (39%)
		SIM_C	358..668	CDD:369005	66/342 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910