DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1233 and Zfp423

DIOPT Version :9

Sequence 1:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001380647.1	Gene:	Zfp423 / 94188	RGDID:	621664	Length:	1292	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	106/470 - (22%)
Similarity:	162/470 - (34%)	Gaps:	158/470 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   783 LSLGPNQVPEGGKCLVEGCMFRFKSPVTLEY---HGRCHNGSLSSNQPVVCPECKSSNFSNWNCL 844
            |.||..   |||..|...|.|..||.:.|.|   |.:.|:..|    |..|..| |..|.:....
  Rat   133 LGLGEE---EGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKL----PFKCTFC-SRLFKHKRSR 189

  Fly   845 HTHLWRTHQIDMELYSCQLCSFKTPIYSRL--VNTHAKIHSEERNYKCEQCGKGFKNTKQLKNHR 907
            ..|: :.|..|.: |.|..|.   ..:||.  :..|.|.||..:.:||..|.:||.:|..|::|.
  Rat   190 DRHI-KLHTGDKK-YHCHECE---AAFSRSDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHM 249

  Fly   908 RLHRTQGLGMGKQSNEQISVGPEGNPVVMHRCEDCGAAFKQKKTLREHLCK-----ERNEQLECP 967
            :.|        |::.|.::...:........|:.|...|.|.:.|.:|:..     .....|:|.
  Rat   250 QAH--------KKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKADLQCI 306

  Fly   968 ECQRRFGSKSSLRLHLRSHQEH--KRFRCDTCDHETSDHNAYRRHLATHKE-------------- 1016
            .|...|..:|:|..|:  ||.|  ::.:|..|..:.|.......||.:|::
  Rat   307 HCPEVFVDESTLLAHI--HQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVL 369

  Fly  1017 --------------------------------SKR------------YSCPHCDFRAIQSTA-FR 1036
                                            .|:            ||||:|..|...|.| ..
  Rat   370 GSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQSWSKVVYSCPYCSKRDFTSLAVLE 434

  Fly  1037 IHLQTRH---PEQELSTII----------------------------------YKCNQC--NFTS 1062
            |||:|.|   |:|..:..|                                  :.||.|  .|..
  Rat   435 IHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFAD 499

  Fly  1063 INQGLLQVH--------QAKHDAGNH----NQTLASSQGDVPVEKQSQIKVESNLVLAH---SST 1112
            ||.  ||.|        .|....||:    ||   .|.|.:     ::..:..::..||   .||
  Rat   500 INS--LQEHIRVSHCGPNANPPDGNNAFFCNQ---CSMGFL-----TESSLTEHIQQAHCSVGST 554

  Fly  1113 KVATEVIKAQENILQ 1127
            |:.:.||:..::.::
  Rat   555 KLESPVIQPTQSFME 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	5/21 (24%)
		C2H2 Zn finger	861..882	CDD:275368	6/22 (27%)
		zf-H2C2_2	875..899	CDD:290200	9/23 (39%)
		zf-C2H2	888..910	CDD:278523	8/21 (38%)
		C2H2 Zn finger	890..910	CDD:275368	7/19 (37%)
		zf-C2H2_2	893..999	CDD:289522	27/112 (24%)
		C2H2 Zn finger	939..956	CDD:275368	5/16 (31%)
		RPB9	966..1061	CDD:224510	35/194 (18%)
		C2H2 Zn finger	966..986	CDD:275368	6/19 (32%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1022..1042	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1055..1075	CDD:275368	10/29 (34%)
Zfp423	NP_001380647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..123
		C2H2 Zn finger	148..168	CDD:275368	7/19 (37%)
		C2H2 Zn finger	176..196	CDD:275368	5/21 (24%)
		COG5048	202..603	CDD:227381	82/391 (21%)
		C2H2 Zn finger	204..224	CDD:275368	6/22 (27%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..292	CDD:275368	6/18 (33%)
		C2H2 Zn finger	419..440	CDD:275368	9/20 (45%)
		C2H2 Zn finger	451..475	CDD:275368	1/23 (4%)
		C2H2 Zn finger	490..509	CDD:275368	9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..635
		C2H2 Zn finger	672..692	CDD:275368
		C2H2 Zn finger	702..723	CDD:275368
		C2H2 Zn finger	730..751	CDD:275368
		C2H2 Zn finger	760..781	CDD:275368
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	817..835	CDD:275368
		C2H2 Zn finger	896..917	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	969..989	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1171
		C2H2 Zn finger	1208..1228	CDD:275368
		C2H2 Zn finger	1239..1260	CDD:275368
		C2H2 Zn finger	1269..1285	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100