DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1233 and ZBTB10

DIOPT Version :9

Sequence 1:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001099009.1	Gene:	ZBTB10 / 65986	HGNCID:	30953	Length:	871	Species:	Homo sapiens

Alignment Length:	832	Identity:	158/832 - (18%)
Similarity:	235/832 - (28%)	Gaps:	299/832 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 REPLPDFPP-LMPDSGSAANILDLLEGVAVGASPTEQTMPTAPAAN---------LPAPPPKPIQ 330
            |:|.|..|| |.|.:|..|:....|||:    .|.:......|||.         ||.....|..
Human    45 RQPPPPAPPALQPPNGRGADEEVELEGL----EPQDLEASAGPAAGAAEEAKELLLPQDAGGPTS 105

  Fly   331 KISIKSVDVLRETALLPFDFQ------LQNHSVNTDNSLPEVPDVVGEPE---------KPRQPK 380
            ........:|.|.......|:      |.|:..:.           |.||         ..|.|.
Human   106 LGGGAGGPLLAERNRRTLAFRGGGGGGLGNNGSSR-----------GRPETSVWPLRHFNGRGPA 159

  Fly   381 IYIRNVDILKEPMVLP---------------------SALPGLGFNSTMPSAAEPGQ--SGLVVG 422
            .....:|.|:...::.                     |...|...:|:..|..:.|.  .|..||
Human   160 TVDLELDALEGKELMQDGASLSDSTEDEEEGASLGDGSGAEGGSCSSSRRSGGDGGDEVEGSGVG 224

  Fly   423 GADGDVFQSETLLTPTCQLPGFEPSLAPLAQMCS------EAFPF-----DSVLNGNG----APA 472
            ..:|:..|...|..|        .||....| ||      :.||:     |:.|...|    .||
Human   225 AGEGETVQHFPLARP--------KSLMQKLQ-CSFQTSWLKDFPWLRYSKDTGLMSCGWCQKTPA 280

  Fly   473 AHVENTRFSALDLDFG-VDFVSEEATPPPPLNDPL---------TMMEPQPVQLEHYMPPT---- 523
                         |.| ||.       ||..:|.|         |::....|..||.:...
Human   281 -------------DGGSVDL-------PPVGHDELSRGTRNYKKTLLLRHHVSTEHKLHEANAQE 325

  Fly   524 ----------------------------------------APITTKQKIFIKNVDILKAPQRGTL 548
                                                    ..|....|||..:.:||.|..|...
Human   326 SEIPSEEGYCDFNSRPNENSYCYQLLRQLNEQRKKGILCDVSIVVSGKIFKAHKNILVAGSRFFK 390

  Fly   549 HLRTVDELNLMNRTEVEHLIVPNLEPMAMTM-----MELPPVQQQPMEVTS-----QLKGPTETL 603
            .|.........|:....||.:..::..::.:     ..|....|..:||.:     |:....:|.
Human   391 TLYCFSNKESPNQNNTTHLDIAAVQGFSVILDFLYSGNLVLTSQNAIEVMTVASYLQMSEVVQTC 455

  Fly   604 GEF-QPSISESWPSEDGYDLPEDLECWPWMEDAVPEAGLVLPTPSEVANAPPL--DGLS------ 659
            ..| :.:::.|..||                  .||:.:|     :..|..|:  ||||
Human   456 RNFIKDALNISIKSE------------------APESVVV-----DYNNRKPVNRDGLSSSRDQK 497

  Fly   660 -------HNAVDLL---------------------VKDFSHLYAAPPEDTQNAEEGTA------- 689
                   .|..:|.                     :.|.|.:....||..:|..||..
Human   498 IASFWATRNLTNLASNVKIENDGCNVDEGQIENYQMNDSSWVQDGSPEMAENESEGQTKVFIWNN 562

  Fly   690 AGGRGTVPPLVPVTSSEGTASVAQSAALGSLPVPPLVPLAAEMNAAIEKPARIYVANNLLPAAVD 754
            .|.:|       :..:..|....|:.......:||......| :.::.:|...|...|.|....:
Human   563 MGSQG-------IQETGKTRRKNQTTKRFIYNIPPNNETNLE-DCSVMQPPVAYPEENTLLIKEE 619

  Fly   755 PPLLG-------------------GGTSVRGRPYGAKHS------GGAASKRKLSLGPNQVPEGG 794
            |.|.|                   .|||..|...|..|.      .|.::..|..|.|....:..
Human   620 PDLDGALLSGPDGDRNVNANLLAEAGTSQDGGDAGTSHDFKYGLMPGPSNDFKYGLIPGTSNDFK 684

  Fly   795 KCLVEGCMFRFKSPVTLEYHGRCHNGSLSSNQPVVCPECKSSNFSNWNCLHTHLWRTHQIDMELY 859
            ..|:.|....||            .|.|..:.|      |...:.|..         ..:.|...
Human   685 YGLIPGASNDFK------------YGLLPESWP------KQETWENGE---------SSLIMNKL 722

  Fly   860 SCQLCSFKTPIYSRLVNTHAKIHSEERNYKCEQCGKGFKNTKQLKNHRRLHR 911
            .|..||:... |.|.:..|..||:..|::.|:.|||.|...:.:|.|..:|:
Human   723 KCPHCSYVAK-YRRTLKRHLLIHTGVRSFSCDICGKLFTRREHVKRHSLVHK 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	2/21 (10%)
		C2H2 Zn finger	861..882	CDD:275368	6/20 (30%)
		zf-H2C2_2	875..899	CDD:290200	9/23 (39%)
		zf-C2H2	888..910	CDD:278523	7/21 (33%)
		C2H2 Zn finger	890..910	CDD:275368	7/19 (37%)
		zf-C2H2_2	893..999	CDD:289522	7/19 (37%)
		C2H2 Zn finger	939..956	CDD:275368
		RPB9	966..1061	CDD:224510
		C2H2 Zn finger	966..986	CDD:275368
		C2H2 Zn finger	994..1014	CDD:275368
		C2H2 Zn finger	1022..1042	CDD:275368
		C2H2 Zn finger	1055..1075	CDD:275368
ZBTB10	NP_001099009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..156		27/125 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..228		8/50 (16%)
		ZnF_TTF	249..>316	CDD:214739	18/86 (21%)
		BTB	354..460	CDD:279045	19/105 (18%)
		BTB	365..461	CDD:197585	19/95 (20%)
		zf-H2C2_5	722..744	CDD:290620	6/22 (27%)
		C2H2 Zn finger	724..744	CDD:275368	6/20 (30%)
		zf-H2C2_2	737..761	CDD:290200	9/23 (39%)
		C2H2 Zn finger	752..772	CDD:275368	7/19 (37%)
		zf-H2C2_2	764..787	CDD:290200	3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000