DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1233 and Zfp316

DIOPT Version :9

Sequence 1:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_059495.3	Gene:	Zfp316 / 54201	MGIID:	1860402	Length:	1017	Species:	Mus musculus

Alignment Length:	481	Identity:	120/481 - (24%)
Similarity:	174/481 - (36%)	Gaps:	129/481 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 PEDLECWPWMEDAVPEAGL--------------VLPTPSEVANAPPL--------------DGLS 659
            ||:||..| .|...||||:              |:..|:..|..|..              :||:
Mouse   540 PEELEAAP-AETEEPEAGVADGDTEAEARQDEQVVVAPAAEATVPDSKKDPEPDRRFREMGNGLA 603

  Fly   660 HNA----------VDLLVKDFSHLYAAP----PEDTQNAEEGTAAGGRGTVPPLVPVTSSEGTA- 709
            ...          ..:..|.:.|....|    ||.::..:    |.||....||....|.:|..
Mouse   604 EGEGPSSHPFGFHFPMHPKSWLHPDGFPILGFPEFSERLQ----ADGRHLPGPLGSPLSLQGMGL 664

  Fly   710 ------SVAQSAAL--GSLPVPPLVPLAAEMNAAIEKPARIYVANNLLPAAV---DPPLLGGGTS 763
                  ||...|.:  |....||.|      .:.:.:||         |||:   :.|.:   .|
Mouse   665 ACDPFRSVGPGAGVDGGLRAFPPAV------RSLLSEPA---------PAALAEEESPWI---CS 711

  Fly   764 VRGRPYG-----AKHSGGAASKRKLSLGPNQVPEGGKCLVEGCMFRFKSPVTLEYHGRCHNGSLS 823
            ..|:.:|     |||....|.:|     |::..:.||..|.|.        .|..|.|.|.|
Mouse   712 DCGKTFGRRAALAKHQRYHAGER-----PHRCADCGKSFVYGS--------HLARHRRTHTG--- 760

  Fly   824 SNQPVVCPECKSSNFSNWNCLHTHLWRTHQIDMELYSCQLCSFKTPIYSRL--VNTHAKIHSEER 886
             .:|..|||| .:.|:..:.|..|: |.|..: :.:.|.:|...   :||.  :..|.:.|:.||
Mouse   761 -ERPFPCPEC-GARFARGSHLAAHV-RGHTGE-KPFVCGVCGAG---FSRRAHLTAHGRAHTGER 818

  Fly   887 NYKCEQCGKGFKNTKQLKNHRRLHRTQGLGMGKQSNEQISVGPEGNPVVMHRCEDCGAAFKQKKT 951
            .|.|.:||:.|..:..|..|:..|                  .|..|   |||.|||..|.....
Mouse   819 PYACAECGRRFGQSAALTRHQWAH------------------AEEKP---HRCPDCGKGFGHSSD 862

  Fly   952 LREHLCKERNEQ-LECPECQRRFGSKSSLRLHLRSHQEHKRFRCDTCDHETSDHNAYRRHLATHK 1015
            .:.|......|: ..|.:|.|.|..:|:|..|.|.|...:.|.|..|....|..:....|..||.
Mouse   863 FKRHRRTHTGEKPFRCADCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHT 927

  Fly  1016 ESKRYSCPHCDFRAIQSTAFRIHLQT 1041
            ..:.|.|.:|..|..||:....|::|
Mouse   928 GERPYLCSNCGRRFSQSSHLLTHMKT 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	8/21 (38%)
		C2H2 Zn finger	861..882	CDD:275368	5/22 (23%)
		zf-H2C2_2	875..899	CDD:290200	9/23 (39%)
		zf-C2H2	888..910	CDD:278523	7/21 (33%)
		C2H2 Zn finger	890..910	CDD:275368	6/19 (32%)
		zf-C2H2_2	893..999	CDD:289522	29/106 (27%)
		C2H2 Zn finger	939..956	CDD:275368	5/16 (31%)
		RPB9	966..1061	CDD:224510	24/76 (32%)
		C2H2 Zn finger	966..986	CDD:275368	8/19 (42%)
		C2H2 Zn finger	994..1014	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1022..1042	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1055..1075	CDD:275368
Zfp316	NP_059495.3	KRAB	155..215	CDD:214630
		COG5048	<339..499	CDD:227381
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	383..408	CDD:372612
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	483..501	CDD:275368
		PRK13108	<507..584	CDD:237284	13/44 (30%)
		C2H2 Zn finger	710..730	CDD:275368	6/19 (32%)
		zf-C2H2	710..730	CDD:333835	6/19 (32%)
		zf-H2C2_2	722..747	CDD:372612	8/29 (28%)
		C2H2 Zn finger	738..758	CDD:275368	7/27 (26%)
		COG5048	<763..950	CDD:227381	59/213 (28%)
		C2H2 Zn finger	766..786	CDD:275368	8/21 (38%)
		C2H2 Zn finger	794..814	CDD:275368	5/22 (23%)
		C2H2 Zn finger	822..842	CDD:275368	6/19 (32%)
		C2H2 Zn finger	850..870	CDD:275368	6/19 (32%)
		C2H2 Zn finger	878..898	CDD:275368	8/19 (42%)
		C2H2 Zn finger	906..926	CDD:275368	4/19 (21%)
		C2H2 Zn finger	934..954	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010