DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1233 and ZBTB21

DIOPT Version :9

Sequence 1:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001091872.1	Gene:	ZBTB21 / 49854	HGNCID:	13083	Length:	1066	Species:	Homo sapiens

Alignment Length:	965	Identity:	181/965 - (18%)
Similarity:	297/965 - (30%)	Gaps:	358/965 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 LVVG-----------GADGDVFQS-----ETLLTPTCQLPGFEPSLAPLAQMCSEAFPFDSVLNG 467
            |:||           .|..:.|||     |.......||...||.            .||:|||.
Human    34 LIVGDQKFRAHKNVLAASSEYFQSLFTNKENESQTVFQLDFCEPD------------AFDNVLNY 86

  Fly   468 NGAPAAHVENTRFSA---LDLDFGVDFVSE--EATPPPPLNDPLTMMEPQPVQLEHYMPPTAPIT 527
            ..:.:..||.:..:|   |....|:.|::.  ..||..|.                   ||.|
Human    87 IYSSSLFVEKSSLAAVQELGYSLGISFLTNIVSKTPQAPF-------------------PTCP-- 130

  Fly   528 TKQKIFIKNVD-------ILKAPQRGTLHLRTVDELNLMNRTEVEHLIVPN-------------- 571
            .::|:|:::.:       ::....|.....:||.:    |:.:|.|...|:
Human   131 NRKKVFVEDDENSSQKRSVIVCQSRNEAQGKTVSQ----NQPDVSHTSRPSPSIAVKANTNKPHV 191

  Fly   572 ---LEP---MAMTMMELPP----VQQQPMEVTSQLKGPTETLGEFQPSISESWPSEDGYDLPEDL 626
               :||   :::|....|.    |..:.:|.:..|..|.......:.::..|.|.:|    .|.:
Human   192 PKPIEPLHNLSLTEKSWPKDSSVVYAKSLEHSGSLDDPNRISLVKRNAVLPSKPLQD----REAM 252

  Fly   627 ECWPWMEDAVP-----EAGLVLPTPSEVANAPPLDGLSHNAVDLLVKD---------------FS 671
            :..|.:...:|     |..|..|.|      |.|...|.:....|:|:               :|
Human   253 DDKPGVSGQLPKGKALELALKRPRP------PVLSVCSSSETPYLLKETNKGNGQGEDRNLLYYS 311

  Fly   672 HLYAAPPEDTQNAEEGTAAGGR--------------------GTVP---PLVPVTSSEGTASVAQ 713
            .|....|      ..|:.:|.:                    ..||   |.:.:.||:|::||:.
Human   312 KLGLVIP------SSGSGSGNQSIDRSGPLVKSLLRRSLSMDSQVPVYSPSIDLKSSQGSSSVSS 370

  Fly   714 SA---------------------AL------------------------GSLPVPPLVPLAAEMN 733
            .|                     ||                        |:.||.. |.:..|.:
Human   371 DAPGNVLCALSQKSSLKDCSEKTALDDRPQVLQPHRLRSFSASQSTDREGASPVTE-VRIKTEPS 434

  Fly   734 AAIEKPA---RIYVANNLLPAAVDPPLLGGGTSVRGRPYGAKHSGGAASKR----------KLSL 785
            :.:..|:   |:.|.:....||.....:....|::........|...|.:|          ||.:
Human   435 SPLSDPSDIIRVTVGDAATTAAASSSSVTRDLSLKTEDDQKDMSRLPAKRRFQADRRLPFKKLKV 499

  Fly   786 GPNQVP-------EGG-------------------------------KCLVEGCMFRFKSPVTLE 812
            ..:..|       ||.                               ||  :.|:..|:|...|.
Human   500 NEHGSPVSEDNFEEGSSPTLLDADFPDSDLNKDEFGELEGTRPNKKFKC--KHCLKIFRSTAGLH 562

  Fly   813 YH-GRCHNGSLSSNQPVVCPECKS---SNFSNW-NCLHTH------------------------- 847
            .| ...||    ..:|..|..|..   :||..| :|...|
Human   563 RHVNMYHN----PEKPYACDICHKRFHTNFKVWTHCQTQHGIVKNPSPASSSHAVLDEKFQRKLI 623

  Fly   848 -LWRTHQIDMEL----------YSCQLCSFKTPIYSRLVNTHAKIHSEERNYKCEQCGKGFKNTK 901
             :.|..:|...|          :..|..|....:..|.:.:.||     ..|.|..|||.::...
Human   624 DIVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKRNLRSRAK-----GAYICTYCGKAYRFLS 683

  Fly   902 QLKNHRRLH-RTQGLGMGKQSNEQISVGPEGNPV---VMHRCEDCGAAFKQ--KKTLREHLCKER 960
            |.|.|.::| ..:.||:.|.:..: ...|..:||   .:::|..|.|....  ::...|.||  |
Human   684 QFKQHIKMHPGEKPLGVNKVAKPK-EHAPLASPVENKEVYQCRLCNAKLSSLLEQGSHERLC--R 745

  Fly   961 NEQLECPECQRRFGSKSSLRLHLRSHQEHKRFRCDTCDHE-TSDHNAYRRHLATHKE-----SKR 1019
            |..: ||.|..||.|....:.| .|..|:|:..|..|... .|..:.:|..:..|.:     ::.
Human   746 NAAV-CPYCSLRFFSPELKQEH-ESKCEYKKLTCLECMRTFKSSFSIWRHQVEVHNQNNMAPTEN 808

  Fly  1020 YSCPHCDFRAIQSTAFR----------IHLQTRHPEQELSTIIYKCNQCNFTSINQGLLQVHQAK 1074
            :|.|..|.....:.:.|          .|:.|...:...|.   ...|.||.|.:...|
Human   809 FSLPVLDHNGDVTGSSRPQSQPEPNKVNHIVTTKDDNVFSD---SSEQVNFDSEDSSCL------ 864

  Fly  1075 HDAGNHNQTLASSQGDVPVEKQSQIKVESNLVLAHSSTKVATEVIKAQENILQAS 1129
                         ..|:.:.||.:|:|:..            .|.:|:|...:||
Human   865 -------------PEDLSLSKQLKIQVKEE------------PVEEAEEEAPEAS 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	8/51 (16%)
		C2H2 Zn finger	861..882	CDD:275368	5/20 (25%)
		zf-H2C2_2	875..899	CDD:290200	7/23 (30%)
		zf-C2H2	888..910	CDD:278523	8/21 (38%)
		C2H2 Zn finger	890..910	CDD:275368	7/19 (37%)
		zf-C2H2_2	893..999	CDD:289522	33/111 (30%)
		C2H2 Zn finger	939..956	CDD:275368	4/18 (22%)
		RPB9	966..1061	CDD:224510	24/110 (22%)
		C2H2 Zn finger	966..986	CDD:275368	7/19 (37%)
		C2H2 Zn finger	994..1014	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1022..1042	CDD:275368	4/29 (14%)
		C2H2 Zn finger	1055..1075	CDD:275368	5/19 (26%)
ZBTB21	NP_001091872.1	BTB	20..120	CDD:279045	23/97 (24%)
		Mediates homodimerization	30..96		18/73 (25%)
		BTB	31..120	CDD:197585	23/97 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..196		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..442		8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..485		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..525		3/26 (12%)
		C2H2 Zn finger	548..569	CDD:275368	6/22 (27%)
		zf-C2H2	670..692	CDD:278523	8/21 (38%)
		C2H2 Zn finger	672..692	CDD:275370	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	806..840		5/33 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..906		5/28 (18%)
		C2H2 Zn finger	911..931	CDD:275370
		C2H2 Zn finger	939..960	CDD:275370
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..1014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100