DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1233 and Zfp354c

DIOPT Version :9

Sequence 1:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_038950.3	Gene:	Zfp354c / 30944	MGIID:	1353621	Length:	560	Species:	Mus musculus

Alignment Length:	581	Identity:	147/581 - (25%)
Similarity:	212/581 - (36%)	Gaps:	119/581 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   537 VDILKAPQRGT--LHLRTV------DE---LNLMNRTEVEHLIVPNLEPMAMT--MMELPPVQQQ 588
            ||:|.|  |||  :..|.|      ||   |:...|:....:::.|...:|..  ...:|||
Mouse     3 VDLLAA--RGTEPVTFRDVAVSFSQDEWLHLDPAQRSLYREVMLENYSNLASLGFQASIPPV--- 62

  Fly   589 PMEVTSQLKGPTETLGEFQPSISESWPSEDGYDLPEDLECWPWMEDAVPEAGLVLPTPSEVANAP 653
                          :|:.|.........|...|...|.|.||.:|        .||...:|....
Mouse    63 --------------IGKLQKGQDPCMEREAPEDTCLDFEIWPEIE--------ALPPKQDVLTKE 105

  Fly   654 PLDGLSHNAVDLLVK---DFSHLYAAPPEDTQNAEEGTAAGGRGTVPPLVPVTSSEGTASVAQSA 715
            ...||..|.....|.   .|..|......|....:|....|.....|.  ..||.:||.:
Mouse   106 TSHGLIKNGSTKCVYWKISFGELVKTECRDIAQEQEKKVHGPGAESPK--ETTSEDGTPT----- 163

  Fly   716 ALGSLPVPPL----VPLAAEMNAAIEKPARIYVANNLLPAAVD------------PPL---LGGG 761
              |..|..||    ..::.|.:.....||..:.:...||...|            |.:   .|.|
Mouse   164 --GFEPEKPLFISKALVSQEGDPTESVPATYHTSEKDLPQDFDLMRSFQMYPGQKPHVCSECGKG 226

  Fly   762 TS------------VRGRPYGAKHSGGAASKRKLSLGPNQVPEGG---KCLVEGCMFRFKSPVTL 811
            .:            ...:||.....|.:.|.|...|...:...|.   ||  ..|...|.|..||
Mouse   227 FTQSLHLLEHKRLHTGEKPYKCSECGKSFSHRSSLLAHQRTHTGEKPYKC--SECEKAFGSSSTL 289

  Fly   812 EYHGRCHNGSLSSNQPVVCPECKSSNFSNWNCLHTHLWRTHQIDMELYSCQLCSFKTPIYSRLVN 876
            ..|.|.|.|    .:|..|.:|..: ||..:.|..| .|.|..: :||.|..|.......::| :
Mouse   290 IKHLRVHTG----EKPYRCRQCGKA-FSQCSTLTVH-QRIHTGE-KLYKCAECDKAFNCRAKL-H 346

  Fly   877 THAKIHSEERNYKCEQCGKGFKNTKQLKNHRRLHR----TQGLGMGKQ--------SNEQISVGP 929
            .|.:||:.|:.|||.:||||:.....|..|:|||.    .|.|..|:.        .:::|..|.
Mouse   347 RHQRIHTGEKPYKCAECGKGYSQFPSLAEHQRLHTGEQLCQCLQCGRTFTRVSTLIEHQRIHTGQ 411

  Fly   930 EGNPVVMHRCEDCGAAFKQKKTLREHLCKERNEQL-ECPECQRRFGSKSSLRLHLRSHQEHKRFR 993
            :     .::|.:||..|.|..:..||......|:| .|.||.:.||.||:|..|.|.|...|.::
Mouse   412 K-----PYQCNECGKTFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQ 471

  Fly   994 CDTCDHETSDHNAYRRHLATHKESKRYSCPHCDFRAIQSTAFRIHLQTRHPEQELSTIIYK 1054
            |:.|....|.::....|...|...|.|.|..|.    ::.::|.:| .||.:..|...:||
Mouse   472 CNQCGKAFSQYSFLTEHERIHTGEKLYKCMECG----KAYSYRSNL-CRHKKVHLKERLYK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	7/21 (33%)
		C2H2 Zn finger	861..882	CDD:275368	4/20 (20%)
		zf-H2C2_2	875..899	CDD:290200	11/23 (48%)
		zf-C2H2	888..910	CDD:278523	10/21 (48%)
		C2H2 Zn finger	890..910	CDD:275368	8/19 (42%)
		zf-C2H2_2	893..999	CDD:289522	37/118 (31%)
		C2H2 Zn finger	939..956	CDD:275368	6/16 (38%)
		RPB9	966..1061	CDD:224510	28/89 (31%)
		C2H2 Zn finger	966..986	CDD:275368	10/19 (53%)
		C2H2 Zn finger	994..1014	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1022..1042	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1055..1075	CDD:275368	147/581 (25%)
Zfp354c	NP_038950.3	KRAB	14..74	CDD:214630	13/76 (17%)
		KRAB	14..53	CDD:279668	8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..168		8/37 (22%)
		COG5048	204..>543	CDD:227381	94/344 (27%)
		C2H2 Zn finger	220..240	CDD:275368	2/19 (11%)
		zf-H2C2_2	232..257	CDD:290200	3/24 (13%)
		C2H2 Zn finger	248..268	CDD:275368	4/19 (21%)
		zf-H2C2_2	260..283	CDD:290200	5/24 (21%)
		C2H2 Zn finger	276..296	CDD:275368	8/21 (38%)
		zf-H2C2_2	289..313	CDD:290200	9/28 (32%)
		C2H2 Zn finger	304..324	CDD:275368	7/21 (33%)
		zf-H2C2_2	317..341	CDD:290200	8/25 (32%)
		C2H2 Zn finger	332..352	CDD:275368	4/20 (20%)
		zf-H2C2_2	347..369	CDD:290200	11/21 (52%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	2/19 (11%)
		zf-H2C2_2	401..425	CDD:290200	6/28 (21%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..451	CDD:290200	7/22 (32%)
		C2H2 Zn finger	444..464	CDD:275368	10/19 (53%)
		zf-H2C2_2	456..481	CDD:290200	7/24 (29%)
		C2H2 Zn finger	472..492	CDD:275368	4/19 (21%)
		zf-H2C2_2	485..509	CDD:290200	6/27 (22%)
		C2H2 Zn finger	500..520	CDD:275368	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910