DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1233 and Zfp438

DIOPT Version :9

Sequence 1:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001347376.1	Gene:	Zfp438 / 240186	MGIID:	2444919	Length:	798	Species:	Mus musculus

Alignment Length:	859	Identity:	157/859 - (18%)
Similarity:	255/859 - (29%)	Gaps:	322/859 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 NSTMPSAAEPGQSGLVVGGA-DGDVFQSETLLTPTCQLPGFEPSLAPLAQMCSEAFPFDSVLNGN 468
            ||:.....:.|:|.:..|.. .|...||::      |.....|.:.|.. :.|...|..|.::..
Mouse     3 NSSSVPPKDQGESNIRSGTTQSGKTLQSKS------QFRTIAPKVVPKV-LTSRVLPCPSSISDQ 60

  Fly   469 GAPAAHVENTRFSALDLDFGVDFVSEEATPPPPLNDPLTMMEPQPVQLEHYMPPTAPITTKQKIF 533
            |:                                   ||:| |:|:.:     ||
Mouse    61 GS-----------------------------------LTLM-PKPLGM-----PT---------- 74

  Fly   534 IKNVDILK-APQRGTLHLRTVDELNLMNRTEVEHLIVPNLEPMAMTMMELPPVQQQPMEVTSQLK 597
             :|..::: |.|.||..|                :..||       :....|||:..|.....||
Mouse    75 -QNYALMQVAGQEGTFSL----------------VAFPN-------VASAQPVQKPRMSTHENLK 115

  Fly   598 GPTETLGEFQPSISE--------SWPSEDGYDLP---------EDLECWP--------WMEDAVP 637
            .|   :..:||..|:        |.|.....|.|         ...:.:|        |.:  :|
Mouse   116 LP---IPRYQPLSSQGLRKKQDLSSPKSGSSDPPGPSQLCHLTSSPQAYPDPHHKPSLWKQ--MP 175

  Fly   638 EAGLVLPTPSEVANAPPLDGLSHNAVDLLVKDFS---HLYAAP---PEDTQNAEEGTA----AGG 692
            ...   |:|:.:..|....|:....:..||.:..   .|.|.|   .||:.:.:...|    ||.
Mouse   176 TLN---PSPTNINTATLTSGVGQGDLSPLVTNSCGDLELSAMPVYTTEDSSSQQSLPASMQKAGC 237

  Fly   693 RGTVPPLVPVTSSE------GTASVAQSAAL--------GSLPVPPL------------------ 725
            .....|..|..:||      .:|....|:|:        |.||:.||
Mouse   238 ARKEAPTTPAIASEELKEQLASAQTVLSSAVQLLSVVPKGKLPILPLPRVKTTEVGKVESDADNA 302

  Fly   726 --------------VPLAAEMNAAIEKPARIYVANNLLPAAVDP---PLLGGGTSVRGRP-YGAK 772
                          :.:....:||.|..::|...:....:|.:.   |:.....|.:.:| .|.|
Mouse   303 ELSLSGCRANCDERLSITEGFDAATEIASKIAALHGSKQSACESAFCPVTKLDLSHKAKPSSGIK 367

  Fly   773 HSGGAASKRKLSLGPNQV----PEGGKCLVEGCMFRFKSPVTLEYHGRCHNG-SLSSNQPVVC-- 830
            ..|     ||..: |:::    .:..||::                |.|.:| ..:.|.|...
Mouse   368 RRG-----RKWKV-PDEILALQGKRRKCII----------------GMCGDGIERARNSPQEARD 410

  Fly   831 --PECKSSNFSNW----------------------------------NCLHTHLWRTHQIDMEL- 858
              |...|..:.|.                                  |.|.:....:.|.|...
Mouse   411 QKPRVASRKYRNIMPKPVLVLSALAPLASHTAVLSQAPSSLGQDVLNNALPSKCLGSKQSDSSTP 475

  Fly   859 -----------------YSCQLCSFKTPIYSRLVNTHAKIHSEERNYKCEQCGKGFKNTKQLKNH 906
                             :.|.:|::.......|:: |...|:..|.|.|..|.|.:.....|..|
Mouse   476 KPSSVLRNGFSGIKKPWHMCPVCNYHFQFKHHLLD-HMNTHTNRRPYSCGICRKTYVRPGSLSAH 539

  Fly   907 RRLHRTQGLGMGKQSNEQISVGPEGNPVVMHRCEDCGAAFKQKKTLREHLCKERNEQLECPECQR 971
            .:||.                 .:.:|..:..||.|...|...:....|| ||.:..:...|
Mouse   540 MKLHH-----------------GDNHPKKLVCCEFCAKVFGHVRVYFGHL-KEVHRVVISTE--- 583

  Fly   972 RFGSKSSLRLHLRSHQEHKRFRCDTCDHETSDHNAYRRHLATHKESKRYSCPHCDFRAIQSTAFR 1036
              .|.|.|:            ..||..::..|........:..:|:|  |....||  :.:.|..
Mouse   584 --PSPSELQ------------PGDTPKNKNRDPGMQGPDNSLERETK--SSLEEDF--LLNQADE 630

  Fly  1037 IHLQTRHPEQELSTIIYKCNQC-----NFTSINQGLLQVHQAKHDAGNHNQTLASSQGDVPVEKQ 1096
            :.||.|            |.:|     :|..|...||.||..:.........|..|:.|.|.:||
Mouse   631 VKLQIR------------CGRCQITAQSFAEIKFHLLHVHGEEIQGRLQEMILPGSRSDAPHQKQ 683

  Fly  1097 -----SQIKVESNL 1105
                 .|:|..::|
Mouse   684 YTERRKQMKPYASL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	5/59 (8%)
		C2H2 Zn finger	861..882	CDD:275368	4/20 (20%)
		zf-H2C2_2	875..899	CDD:290200	7/23 (30%)
		zf-C2H2	888..910	CDD:278523	6/21 (29%)
		C2H2 Zn finger	890..910	CDD:275368	5/19 (26%)
		zf-C2H2_2	893..999	CDD:289522	21/105 (20%)
		C2H2 Zn finger	939..956	CDD:275368	4/16 (25%)
		RPB9	966..1061	CDD:224510	18/99 (18%)
		C2H2 Zn finger	966..986	CDD:275368	4/19 (21%)
		C2H2 Zn finger	994..1014	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1022..1042	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1055..1075	CDD:275368	8/24 (33%)
Zfp438	NP_001347376.1	C2H2 Zn finger	495..515	CDD:275368	4/20 (20%)
		zf-H2C2_2	507..532	CDD:372612	8/25 (32%)
		zf-C2H2	521..543	CDD:333835	6/21 (29%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		C2H2 Zn finger	554..573	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100