DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1233 and Zbtb48

DIOPT Version :9

Sequence 1:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_017175372.1	Gene:	Zbtb48 / 100090	MGIID:	2140248	Length:	767	Species:	Mus musculus

Alignment Length:	712	Identity:	149/712 - (20%)
Similarity:	227/712 - (31%)	Gaps:	220/712 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   560 NRTEV----EHLIVPNLEPMAMTMMELPPVQQ------QP--MEVTSQLKGPTETLGEFQPSISE 612
            ||.:|    :.|.||....:..:......|.|      ||  .:|.|.||.||: |.|.:...:.
Mouse   121 NRDQVLLAAKELRVPEAVELCQSFQPQTSVGQAQSGLGQPASQDVKSHLKEPTD-LDEEEVFRTL 184

  Fly   613 SWPSEDGYDLPEDLECWPWMEDAVPEAGLVLPTPSEVANAPPLDGLSHNAVDLLVKDFSHLYAAP 677
            |..|.|  ..|.|.|        .|:.|    ||::...|           .|..|....|..:|
Mouse   185 SLASVD--QEPRDTE--------QPQLG----TPAQSTTA-----------FLCGKLTQALKPSP 224

  Fly   678 PEDTQNAE-----EGTAAGGRGTVPPLVPVTSSEGTASVAQSAALGSLPVPPLVPLAAEMNAAIE 737
            .||.::.:     ....|||    .||...::........:....|.....|...|....:..|.
Mouse   225 SEDKESEDCKEPPRPFEAGG----APLQGESNEWEVVVQVEDDRDGDYVSEPETVLTRRKSKVIR 285

  Fly   738 KPARIYVANNLLPAAVDPPLLGGGTSVRGRPYGAKHSGGAASKRKLSLGPNQVPEGGKCLVEGCM 802
            |           |.|.:|.|  |..|:...|         ...||.:..|.:.|.        |.
Mouse   286 K-----------PCAAEPAL--GAGSLTAEP---------TDSRKGAAVPVECPT--------CH 320

  Fly   803 FRFKSPVTLEYHGRCHNGSLSSNQPVVCPECKSSNFSNWNCLHTHLWRTHQIDMELYSCQLC--S 865
            .:|.|...|:.|.|.|.|    .:|..||:|....|...|.|............::::|.:|  :
Mouse   321 KKFLSKYYLKVHNRKHTG----EKPFECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQET 381

  Fly   866 FKTPIYSRLVNTHAKIHSEERNYKCEQCGKGFKNTKQLKNHR-RLH---------RTQGLGMGKQ 920
            |:..:..||   |...|:.|..|||..|.:.|...|.|::|. :||         .:||.|.|..
Mouse   382 FRRRMELRL---HMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHAVSASQGWGSGGS 443

  Fly   921 SNEQ------------------------------------------------------------- 924
            ...|
Mouse   444 GTAQSCPHLDVLPLPVSPTCSAPLVPSASCLGRSYSCTRLLSIVEKSSLCVRNAGTGPRAATDCR 508

  Fly   925 ------------ISVGPEGNPVVMHRCEDCGAAFKQKKTL-------REHLCKERNEQ-LECPEC 969
                        :||.....|........|..|....::|       |....|.|..| |..|..
Mouse   509 CTSRPSTGMKGLMSVSSAAMPSPRRPTSTCTCAHTPARSLSSATSVGRPSAPKVRQAQPLLAPGL 573

  Fly   970 QRRFGSK----SSLRLHLRSHQEHKRFRCDTCDHETSDHNAYRRHLAT-HKESKRYSCPHC--DF 1027
            ::...|.    :||..|.|:|...:.|.|:.|:...::.....||:|: |:|.:.:.|..|  .|
Mouse   574 RQPLSSTLSPIASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTF 638

  Fly  1028 RAIQSTAFRIHLQTRHPEQELSTIIYKCNQCNFTSINQGLLQVHQAKHD-AGNHN---------- 1081
            :|::.  .|:|:: ||.    ....::|.:|.:....|..|:.|...|| ..|:|
Mouse   639 KAVEQ--LRVHVR-RHK----GVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLI 696

  Fly  1082 --------------QTLASSQGDVPVEKQSQIKVESNLVLAHSSTKVATEVIKAQENILQAS 1129
                          ..|.....:|.||..:|..:.|.|    .|.::.:|...|...:|:.|
Mouse   697 IEDEKMVVVALQPPADLEVGSAEVIVESLTQGGLASQL----PSQRLCSEESFASPGVLEPS 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	6/21 (29%)
		C2H2 Zn finger	861..882	CDD:275368	6/22 (27%)
		zf-H2C2_2	875..899	CDD:290200	8/23 (35%)
		zf-C2H2	888..910	CDD:278523	8/22 (36%)
		C2H2 Zn finger	890..910	CDD:275368	6/20 (30%)
		zf-C2H2_2	893..999	CDD:289522	33/200 (17%)
		C2H2 Zn finger	939..956	CDD:275368	4/23 (17%)
		RPB9	966..1061	CDD:224510	25/101 (25%)
		C2H2 Zn finger	966..986	CDD:275368	6/23 (26%)
		C2H2 Zn finger	994..1014	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1022..1042	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1055..1075	CDD:275368	5/19 (26%)
Zbtb48	XP_017175372.1	BTB_POZ_ZBTB48_TZAP_KR3	38..145	CDD:349541	6/23 (26%)
		C2H2 Zn finger	316..336	CDD:275368	7/27 (26%)
		zf-H2C2_2	328..351	CDD:372612	9/26 (35%)
		C2H2 Zn finger	344..395	CDD:275368	12/53 (23%)
		zf-H2C2_2	387..410	CDD:372612	9/25 (36%)
		C2H2 Zn finger	403..424	CDD:275368	6/20 (30%)
		PHA03247	<426..583	CDD:223021	18/156 (12%)
		zf-H2C2_2	586..610	CDD:372612	8/23 (35%)
		C2H2 Zn finger	602..623	CDD:275368	5/20 (25%)
		C2H2 Zn finger	631..651	CDD:275368	6/22 (27%)
		zf-H2C2_2	644..668	CDD:372612	6/28 (21%)
		zf-C2H2	657..679	CDD:333835	5/21 (24%)
		C2H2 Zn finger	659..679	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100