DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and DMTF1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001135799.1	Gene:	DMTF1 / 9988	HGNCID:	14603	Length:	760	Species:	Homo sapiens

Alignment Length:	741	Identity:	121/741 - (16%)
Similarity:	223/741 - (30%)	Gaps:	256/741 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKT---------- 61
            |.|:|...|.:||...:.:|.|.:..:.|:.:..:.:|..:..:|..:...:.:.
Human   152 KQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLR 216

  Fly    62 ---------EWSREEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTM 117
                     :::.||.|||..|.......|.||...:||:|:...:|...:.|..   ..|:.|.
Human   217 MYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTC---NTGKWTE 278

  Fly   118 DDPRKL----------KPGEIDPNPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAR 172
            ::.::|          :||:|...                     ..:.|.:|...|.:::::.|
Human   279 EEEKRLAEVVHELTSTEPGDIVTQ---------------------GVSWAAVAERVGTRSEKQCR 322

  Fly   173 EKQLEEARRLATLQKRRELRAAGIGSGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPD 237
            .|.|...                    |.|:..|.::..|              .|.:|.....:
Human   323 SKWLNYL--------------------NWKQSGGTEWTKE--------------DEINLILRIAE 353

  Fly   238 FNKMRQQDLDGELRSEKEERERKRD---------KQKLKQRKENEVPTAM--LQNMEPERKRSKL 291
            .:...:.|::.:|.:|.....|...         |:::...|:...|..:  |:.:...:|.:..
Human   354 LDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPT 418

  Fly   292 VLPTPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAATPRTPAPYTDRIM 356
            :|                        |....||:                      |...|:..:
Human   419 LL------------------------ENKSGSGV----------------------PNSNTNSSV 437

  Fly   357 QEAQNMMALTHTETPLKGGLNTPLHESDFSGVLPKAASIATPNTV----------------IATP 405
            |..|..:|.....|.:.   ::|:........:...:|..:|.||                |...
Human   438 QHVQIRVARLEDNTAIS---SSPMAALQIPVQITHVSSADSPATVDSETITLNSGTLQTFEILPS 499

  Fly   406 FRTQREGGAATPGGF--QTPSSGALVPVKGAGGATGVVNTPAYVRDKLSINPEESMGVTETPAHY 468
            |..|..|   |||.:  ||.||..| |:......|..:...|      ..:||:.:....:|.|.
Human   500 FHLQPTG---TPGTYLLQTSSSQGL-PLTLTASPTVTLTAAA------PASPEQIIVHALSPEHL 554

  Fly   469 KNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIETNSEPAVEDQADVDARLLAEQEARRK 533
            .|....:.....       .||     |:.:...:|.|.::...|
Human   555 LNTSDNVTVQCH-------TPR-----VIIQTVATEDITSSISQA-------------------- 587

  Fly   534 RELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQQAEELIKHEMITMQLYDSVKDPVPGQS 598
             ||...|.:.....|.|.:.              .|.....:.|.|..:|::  .|..|.
Human   588 -ELTVDSDIQSSDFPEPPDA--------------LEADTFPDEIHHPKMTVE--PSFNDA----- 630

  Fly   599 QHKLEQLQSYFKANPYEDISQQELAKAKQMLTEEMEVVKERMAHGELPLDVYAQVWQECLGQ--- 660
                       ..:.:.|.:..||..:..:.||| |:....:...|.|.|:.:....|.|..
Human   631 -----------HVSKFSDQNSTELMNSVMVRTEE-EISDTDLKQEESPSDLASAYVTEGLESPTI 683

  Fly   661 ------------VLYLPSQHRYTRAN 674
                        :|.:||.|.:.:|:
Human   684 EEQVDQTIDDETILIVPSPHGFIQAS 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	10/47 (21%)
		Myb_DNA-bind_6	11..71	CDD:290632	12/78 (15%)
		SANT_CDC5_II	56..108	CDD:212557	14/70 (20%)
		SANT	60..104	CDD:197842	13/62 (21%)
		Myb_Cef	397..648	CDD:288664	49/268 (18%)
DMTF1	NP_001135799.1	Interaction with CCND2. /evidence=ECO:0000250	1..237		16/84 (19%)
		Required for DNA-binding. /evidence=ECO:0000250	87..458		62/412 (15%)
		Required for transcriptional activation. /evidence=ECO:0000250	87..170		6/17 (35%)
		SANT	<89..438	CDD:333364	58/389 (15%)
		Interaction with CCND1, CCND2 and CCND3. /evidence=ECO:0000250	176..760		113/717 (16%)
		Myb_DNA-bind_6	228..284	CDD:316443	16/58 (28%)
		Myb_DNA-binding	274..329	CDD:306708	12/75 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..435		7/66 (11%)
		Required for transcriptional activation. /evidence=ECO:0000250	459..760		58/327 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..760
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900