DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc5 and CEF1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_013940.1	Gene:	CEF1 / 855253	SGDID:	S000004826	Length:	590	Species:	Saccharomyces cerevisiae

Alignment Length:	811	Identity:	223/811 - (27%)
Similarity:	331/811 - (40%)	Gaps:	271/811 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREED 68
            |.:|||||.|.||:||||||.|||.:|||::||||.:|:|:|.:.||.|:|:|.:..||:|:|||
Yeast     6 IYVKGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNPKLNFTEFSKEED 70

  Fly    69 EKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKED--GEDTMDDPRKLKPGEIDPN 131
            .:||.||:.:|.||||||.::.|.|..|:|||..||:    .||  |.........||.|:|:||
Yeast    71 AQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLE----SEDSGGAALSTGVTDLKAGDINPN 131

  Fly   132 PETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAGI 196
            .||:.||||..|::::|.|||:||||||.|||||||.||.||:.|||::|:|.|||||||:.|||
Yeast   132 AETQMARPDNGDLEDEEKEMLAEARARLLNTQGKKATRKIRERMLEESKRIAELQKRRELKQAGI 196

  Fly   197 GSGNRKRIK----GIDYNAEIPFEKRPAHGFYDTSEEHLQ---KNEPDFNKMRQQDLDGELRSEK 254
            ....:|..|    .||||.:|.:|:.|..|.||||.|..|   |.|....|:.::.|||     .
Yeast   197 NVAIKKPKKKYGTDIDYNEDIVYEQAPMPGIYDTSTEDRQIKKKFEQFERKVNRKGLDG-----N 256

  Fly   255 EERERKRDKQKLKQRKENE-VPTAML---QNMEPERKRSKLVLPTPQISDMELQQVVKLGRASEM 315
            :::..|::|.|.::..||| |..|.|   ..:..|.|:.||:|..|
Yeast   257 KDKPSKKNKDKKRKHDENEHVEKAALGESTTLTDEYKKPKLILSAP------------------- 302

  Fly   316 AKEIAGESGIETTDALLADYSITPQVAATPRTPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPL 380
                                       .|.:....|..::..:.|.::
Yeast   303 ---------------------------GTKQGKVTYKKKLESKRQKLI----------------- 323

  Fly   381 HESDFSGVLPKAASIATPNTVIATPFRTQREGGAATPGGFQTPSSGALVPVKGAGGATGVVNTPA 445
                                                                 ...|||.|.||.
Yeast   324 -----------------------------------------------------EAQATGTVLTPK 335

  Fly   446 YVRDKLSINPEESMGVTETPAHYKNYQKQLKSTLRDGL----STLPAPRNDYEIVVPEQEESERI 506
                  .:.|.:|.......::.|: .|||||.:|..|    ::||:|:||:|||:.|.|:.|..
Yeast   336 ------ELLPHDSGQEDNERSNIKS-GKQLKSRIRKFLVQMFASLPSPKNDFEIVLSEDEKEEDA 393

  Fly   507 ETNSEPAVEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQ 571
            |                 :||.|    :|.|..                   |..:|:.|..|..
Yeast   394 E-----------------IAEYE----KEFENE-------------------RAMNEEDNFIEPP 418

  Fly   572 QAEELIKHEMITMQL-YDSVKDPVPGQSQHKLEQLQSYFKANPYEDISQQELAKAKQMLTEEMEV 635
            ...:..:..::.:.| |.::  |:|            .||.||...|..:........:.:|..:
Yeast   419 SQNDAPRVSLVAVPLAYSTL--PIP------------EFKNNPQSAIDNKYNLLVANAINKEPHM 469

  Fly   636 VKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLETNRRHMAKEA 700
            |.|                                      ...|.|:..|.|::    |:.:
Yeast   470 VPE--------------------------------------DTVDFLKEVESRMQ----HITQ-- 490

  Fly   701 KRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFRFLGEQE--------AIAVP 757
               |:...|::..|.  ....:||::.:|.....|||....|...:.|.:|.        ..::|
Yeast   491 ---GRTSMKIQFKTA--MPPTEVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLP 550

  Fly   758 RRLE----------SLQEDVRRQMDREKELQ 778
            ..:|          :.::::|....|.|.||
Yeast   551 ALIEGQRKYYADYYAYRQEIRSLEGRRKRLQ 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	30/47 (64%)
		Myb_DNA-bind_6	11..71	CDD:290632	34/59 (58%)
		SANT_CDC5_II	56..108	CDD:212557	26/51 (51%)
		SANT	60..104	CDD:197842	23/43 (53%)
		Myb_Cef	397..648	CDD:288664	49/255 (19%)
CEF1	NP_013940.1	REB1	1..491	CDD:227476	204/717 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343758
Domainoid	1	1.000	168	1.000	Domainoid score	I795
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002438
OrthoInspector	1	1.000	-	-		oto98963
orthoMCL	1	0.900	-	-		OOG6_102607
Panther	1	1.100	-	-	LDO	PTHR45885
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R188
SonicParanoid	1	1.000	-	-		X1623
TreeFam	1	0.960	-	-
	11	10.730