DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and REB1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_009605.1	Gene:	REB1 / 852338	SGDID:	S000000253	Length:	810	Species:	Saccharomyces cerevisiae

Alignment Length:	384	Identity:	70/384 - (18%)
Similarity:	137/384 - (35%)	Gaps:	105/384 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NQWSRIASLL-HRKSAKQCK--ARWYEWLDPSIKKTEWSREEDEKLLHLAKLMPTQWRTIAPIIG 90
            |.|:.|..:| :|.|:...|  .|.|...:   ::.:|:.||:::|..|......||..|...:|
Yeast   444 NFWNNIYKVLPYRSSSSIYKHMRRKYHIFE---QRGKWTAEEEQELAKLCAEKEGQWAEIGKTLG 505

  Fly    91 RTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLK-------------PGEIDPN---PETKPARP 139
            |....|.:|:...:.....:.....::::...||             ..::.||   .|....:.
Yeast   506 RMPEDCRDRWRNYVKCGTNRASNRWSVEEEELLKKVISDMLEEAQQQQSQLHPNLLEEEQHLLQD 570

  Fly   140 DPKD---MDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAGIGSGNR 201
            |..|   .|||:.:..|.|.|..|..|  :.::..::||.::...:|.     ...||....|:.
Yeast   571 DQNDHRNNDEDDDDTASAAAAAAAAIQ--EQQQLLQQKQQDDDDAIAA-----AAAAASSSLGDN 628

  Fly   202 K-----------RIKGIDYNAEIPFEKRP---AHGFYDTSEEHLQK--------NEPDF------ 238
            |           ::.....|:.:|.....   :....:|...|..|        .:.||
Yeast   629 KDEDKPHDSLGIQLDDNSQNSMVPAPSATSTHSKSLSNTIRRHNNKLRKSLMGNGKLDFKDIINW 693

  Fly   239 --------------------NKMRQQDLDGELRSEKEER-----ERKRDKQKLKQRKENEVPTAM 278
                                ||:.:::...::::.|::.     |:.||   |...::::|....
Yeast   694 TIVSERMGGTRSRIQCRYKWNKLVKREAIAKIQTVKDDDMLWIFEKLRD---LGITEDSQVDWDE 755

  Fly   279 LQNMEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAG--ESGIETTDALLADY 335
            |..::|..|          ::.:||:...:     .|.|::.|  :..|......|.||
Yeast   756 LAALKPGMK----------LNGLELKLCYE-----RMKKKVKGYKQKSINEISKELVDY 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	9/29 (31%)
		Myb_DNA-bind_6	11..71	CDD:290632	12/44 (27%)
		SANT_CDC5_II	56..108	CDD:212557	12/51 (24%)
		SANT	60..104	CDD:197842	12/43 (28%)
		Myb_Cef	397..648	CDD:288664
REB1	NP_009605.1	REB1	202..701	CDD:227476	50/266 (19%)
REB1	NP_009605.1	SANT	<691..719	CDD:197842	2/27 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900