DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and TTF1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_031370.2	Gene:	TTF1 / 7270	HGNCID:	12397	Length:	905	Species:	Homo sapiens

Alignment Length:	792	Identity:	153/792 - (19%)
Similarity:	266/792 - (33%)	Gaps:	262/792 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LANTQGKKAKRKAREKQL---------------EEARRLATLQKRRELR--------AAGI---- 196
            |.|.|.:..:||.|:|..               |.|...:||:||::.|        .||:
Human    42 LVNEQSQITRRKKRKKDFQHLISSPLKKSRICDETANATSTLKKRKKRRYSALEVDEEAGVTVVL 106

  Fly   197 ----GSGNRKR-------IKGIDYNAEIPFEKRP-AHGFYDTSEEHLQKNEPDFNKMRQQDLDGE 249
                ...|..:       :..:|.:.|....::| ...|...::.|..|:|...:|:|      |
Human   107 VDKENINNTPKHFRKDVDVVCVDMSIEQKLPRKPKTDKFQVLAKSHAHKSEALHSKVR------E 165

  Fly   250 LRSEKEER-----ERKRDKQKLKQRKEN---------------EVPTAMLQNMEPERKRSKLVLP 294
            .:::|.:|     |.:|.:..|.|.:.:               |:|.:..:|...::|:..
Human   166 KKNKKHQRKAASWESQRARDTLPQSESHQEESWLSVGPGGEITELPASAHKNKSKKKKKKS---- 226

  Fly   295 TPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAATPRTPAPYTDRIMQEA 359
                |:.| .:.:.:...|:..:| ||                              ||  |||:
Human   227 ----SNRE-YETLAMPEGSQAGRE-AG------------------------------TD--MQES 253

  Fly   360 QNMMALTHTETPLKGGLNTPLHESDFSGVLPKAASIATPNTVIATPFRTQREGGAATPGGFQTPS 424
            |..:.| ..|||...|   |.|:........|.::             .|.....|.|.|.|..|
Human   254 QPTVGL-DDETPQLLG---PTHKKKSKKKKKKKSN-------------HQEFEALAMPEGSQVGS 301

  Fly   425 S-GALV----PVKGAGGATGVVNTPAY----VRDKLSINPEE----------------------S 458
            . ||.:    |..|..|.|..:..|||    .:.|...|.:|                      .
Human   302 EVGADMQESRPAVGLHGETAGIPAPAYKNKSKKKKKKSNHQEFEAVAMPESLESAYPEGSQVGSE 366

  Fly   459 MGVTETPAHYKNYQK----QLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIETNSEPAVEDQAD 519
            :|..|.....|.:::    :.||..|...|...|..:..:..||.:        |||..:.|..:
Human   367 VGTVEGSTALKGFKESNSTKKKSKKRKLTSVKRARVSGDDFSVPSK--------NSESTLFDSVE 423

  Fly   520 VDARLLAEQEARRKRELEKRSQVIQRS-----LPRPTEVNTKILRPQSEKQNLTEQQQAEELIKH 579
            .|..::  :|..:.|..:|::|....|     .||        |.|.:|:.|:...:.:|  |::
Human   424 GDGAMM--EEGVKSRPRQKKTQACLASKHVQEAPR--------LEPANEEHNVETAEDSE--IRY 476

  Fly   580 EMITMQLYDSVKDPVPGQSQHKLEQLQSYFKANPYEDISQQELAKAKQMLTEEMEVVKERMAHG- 643
              ::....|:  |.........::|||.:.     .:|..:..:..|:|..:::|..||..|.|
Human   477 --LSADSGDA--DDSDADLGSAVKQLQEFI-----PNIKDRATSTIKRMYRDDLERFKEFKAQGV 532

  Fly   644 -------------ELPL---DVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLETN 692
                         :|..   |..|....|...::||   ..||..             ||.:.||
Human   533 AIKFGKFSVKENKQLEKNVEDFLALTGIESADKLLY---TDRYPE-------------EKSVITN 581

  Fly   693 -------RRHMAKEAKRCGKI----EKKL---KILTGGYQARAQVLIKQLQDTYG--------QI 735
                   |.|:.:...|..|:    .||:   ....|.|.......:|......|        .:
Human   582 LKRRYSFRLHIGRNIARPWKLIYYRAKKMFDVNNYKGRYSEGDTEKLKMYHSLLGNDWKTIGEMV 646

  Fly   736 EQNSVS-------LSTFRFLGEQEAIAVPRRLESLQEDVRRQMDRE--KELQQKYASLVEE---- 787
            .::|:|       :|:.|..|........:.:::::|.:.::|..:  ||:..|.....|.
Human   647 ARSSLSVALKFSQISSQRNRGAWSKSETRKLIKAVEEVILKKMSPQELKEVDSKLQENPESCLSI 711

  Fly   788 -RDSLYSQIEHI 798
             |:.||..|..:
Human   712 VREKLYKGISWV 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842
		Myb_DNA-bind_6	11..71	CDD:290632
		SANT_CDC5_II	56..108	CDD:212557
		SANT	60..104	CDD:197842
		Myb_Cef	397..648	CDD:288664	60/307 (20%)
TTF1	NP_031370.2	N-terminal region (NRD). /evidence=ECO:0000250	1..223		36/186 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..443		72/366 (20%)
		Myb_DNA-bind_6	621..677	CDD:290632	7/55 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900