DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and Cdc5l

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_690023.1	Gene:	Cdc5l / 71702	MGIID:	1918952	Length:	802	Species:	Mus musculus

Alignment Length:	814	Identity:	512/814 - (62%)
Similarity:	621/814 - (76%)	Gaps:	33/814 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65

  Fly    66 EEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDP 130
            ||:||||||||||||||||||||||||||||||.||:|||:..::::.|:|.|||||||||||||
Mouse    66 EEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDP 130

  Fly   131 NPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAG 195
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||
Mouse   131 NPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAG 195

  Fly   196 IG-SGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFNKMRQQDLDGELRSEKEERER 259
            |. ...||:.:|:||||||||||:||.||||||||:.|..:.||.|:||||||||||||||.|:|
Mouse   196 IEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDR 260

  Fly   260 KRDKQKLKQRKENEVPTAMLQN---MEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAG 321
            |:|||.||::||:::|:|:||.   .|..:||||||||.|||||.|||:|||:|:|||:|::.|.
Mouse   261 KKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAE 325

  Fly   322 ESGI--ETTDALLADYSITPQVAA--TPRTPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPLHE 382
            ||||  ..:..||::|::|....|  ||||||. .|||:|||||:||||:.:|||||||||||||
Mouse   326 ESGITNSASSTLLSEYNVTNNSIALRTPRTPAS-QDRILQEAQNLMALTNVDTPLKGGLNTPLHE 389

  Fly   383 SDFSGVLPKAASIATPNTVIATPFRTQREGG-AATPGGFQTPSSGALVPVKGAGGATGVVNTPAY 446
            ||||||.|:...:.|||||::|||||...|. ..||....||.     ||..|...    .||
Mouse   390 SDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPK-----PVTNATPG----RTP-- 443

  Fly   447 VRDKLSINPEESMGVTETPAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIETN-S 510
            :||||:||||:.|.....|::.|..:::.:..||.||..||||:||:|||:||..|.|..|.. .
Mouse   444 LRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREID 508

  Fly   511 EPAVEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQQAEE 575
            :..:||.||||||..|.::|.|.:|:::..:.:|:.||||:|||..||||.:.:..||:.|::||
Mouse   509 DTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEE 573

  Fly   576 LIKHEMITMQLYDSVKDPVP----------GQSQHKLEQLQSYFKANPYEDISQQELAKAKQMLT 630
            |||.|||||..||.:..|..          |.:.:..|.: :|.:.:|||..|:::|.||:..|.
Mouse   574 LIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHI-TYLEHSPYEKFSKEDLKKAQDALV 637

  Fly   631 EEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLETNRRH 695
            :||||||:.|:||||..:.|.|||:||..||||||:|.|||||||||||||:||.|||||.||.|
Mouse   638 QEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGH 702

  Fly   696 MAKEAKRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFRFLGEQEAIAVPRRL 760
            |..||||..|:|||:|||.||||:||..|:|||.|.:.||||..:.|.||..|.:.|..|:||||
Mouse   703 MTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRL 767

  Fly   761 ESLQEDVRRQMDREKELQQKYASLVEERDSLYSQ 794
            |.|:|||:||.:|||||||:||.|:.|:::|.::
Mouse   768 ECLKEDVQRQQEREKELQQRYADLLMEKETLQAK 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	47/47 (100%)
		Myb_DNA-bind_6	11..71	CDD:290632	58/59 (98%)
		SANT_CDC5_II	56..108	CDD:212557	47/51 (92%)
		SANT	60..104	CDD:197842	40/43 (93%)
		Myb_Cef	397..648	CDD:288664	111/262 (42%)
Cdc5l	NP_690023.1	SANT	8..56	CDD:197842	47/47 (100%)
		Myb_DNA-bind_6	11..71	CDD:290632	58/59 (98%)
		SANT_CDC5_II	56..106	CDD:212557	46/49 (94%)
		SANT	60..106	CDD:197842	42/45 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..143		26/34 (76%)
		Nuclear localization signal. /evidence=ECO:0000255	165..271		80/105 (76%)
		Required for interaction with CTNNBL1. /evidence=ECO:0000250\|UniProtKB:Q99459	200..206		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..278		22/31 (71%)
		Interaction with PPP1R8. /evidence=ECO:0000250\|UniProtKB:Q99459	260..606		176/357 (49%)
		Myb_Cef	404..655	CDD:288664	111/262 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..460		25/62 (40%)
		Interaction with DAPK3. /evidence=ECO:0000250\|UniProtKB:O08837	501..659		65/158 (41%)
		Interaction with PLRG1. /evidence=ECO:0000250\|UniProtKB:Q99459	706..800		55/93 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837005
Domainoid	1	1.000	464	1.000	Domainoid score	I471
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13291
Inparanoid	1	1.050	960	1.000	Inparanoid score	I329
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55711
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002438
OrthoInspector	1	1.000	-	-		otm42361
orthoMCL	1	0.900	-	-		OOG6_102607
Panther	1	1.100	-	-	LDO	PTHR45885
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R188
SonicParanoid	1	1.000	-	-		X1623
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790