DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and Gm9046

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_036012054.1	Gene:	Gm9046 / 668209	MGIID:	3647143	Length:	802	Species:	Mus musculus

Alignment Length:	816	Identity:	507/816 - (62%)
Similarity:	617/816 - (75%)	Gaps:	37/816 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65
            ||||||||||||||||||||||:|||.||||||||||||||||||||||||||||||||||||||
Mouse     1 MPRIMIKGGVWRNTEDEILKAAIMKYRKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65

  Fly    66 EEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDP 130
            ||:||||||||||||||||||||||||||||||.||:|||:..::::.|:|.|||||||||||||
Mouse    66 EEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDP 130

  Fly   131 NPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAG 195
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||
Mouse   131 NPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAG 195

  Fly   196 IG-SGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFNKMRQQDLDGELRSEKEERER 259
            |. ...|||.:|:||||||||||:||.||||||||:.|..:.||.|:||||||||||||||.|:|
Mouse   196 IEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDR 260

  Fly   260 KRDKQKLKQRKENEVPTAMLQN---MEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAG 321
            |.|||:||::||:::|:|:||.   .|..:||||||||.|||||.|||:|||:|:|||:|::.|.
Mouse   261 KTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAE 325

  Fly   322 ESGI--ETTDALLADYSITPQVAA--TPRTPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPLHE 382
            ||||  ..:..||::|::|....|  ||||||| .|||:|||||:||||:.:|||||||||||||
Mouse   326 ESGITNSASSTLLSEYNVTNNSIALRTPRTPAP-QDRILQEAQNLMALTNVDTPLKGGLNTPLHE 389

  Fly   383 SDFSGVLPKAASIATPNTVIATPFRTQREGG-AATPGGFQTPSSGALVPVKGAGGATGVVNTPAY 446
            ||||||.|:...:.|||||::||.||...|. ..||....||.     ||..|        ||..
Mouse   390 SDFSGVTPQRQVVQTPNTVLSTPLRTPSNGAEGLTPRSGTTPK-----PVTNA--------TPGR 441

  Fly   447 --VRDKLSINPEESMGVTETPAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIETN 509
              :||||:||||:.|.....|::.|..:::.:..||.|...||||:||:|||:||..|.|..|..
Mouse   442 TPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEERE 506

  Fly   510 -SEPAVEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQQA 573
             .:..:||.||||||..|.::|.|.:|:::..:.:|:.||||:|||..||||.:.:..||:.|::
Mouse   507 IDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKS 571

  Fly   574 EELIKHEMITMQLYDSVKDPVP----------GQSQHKLEQLQSYFKANPYEDISQQELAKAKQM 628
            |||||.|||||..||.:..|..          |.:.:..|.: :|.:.:|||..|:::|.||:..
Mouse   572 EELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHI-TYLEHSPYEKFSKEDLKKAQGA 635

  Fly   629 LTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLETNR 693
            |.:||||||:.|:||||..:.|.|||:||..|||.|.:|.|||||||||||||:||.|||||.||
Mouse   636 LVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINR 700

  Fly   694 RHMAKEAKRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFRFLGEQEAIAVPR 758
            .||..||||..|:|||:|||.||||:||..|:|||.|.:.||||..:.|.||..|.::|..|:||
Mouse   701 GHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPR 765

  Fly   759 RLESLQEDVRRQMDREKELQQKYASLVEERDSLYSQ 794
            |||.|:|||:.|.:|||||||:||.|:.|:::|.::
Mouse   766 RLECLKEDVQLQQEREKELQQRYADLLMEKETLQAK 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	45/47 (96%)
		Myb_DNA-bind_6	11..71	CDD:290632	56/59 (95%)
		SANT_CDC5_II	56..108	CDD:212557	47/51 (92%)
		SANT	60..104	CDD:197842	40/43 (93%)
		Myb_Cef	397..648	CDD:288664	109/264 (41%)
Gm9046	XP_036012054.1	REB1	6..>303	CDD:227476	241/296 (81%)
Gm9046	XP_036012054.1	Myb_Cef	404..655	CDD:403131	109/264 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837002
Domainoid	1	1.000	464	1.000	Domainoid score	I471
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	960	1.000	Inparanoid score	I329
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55711
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002438
OrthoInspector	1	1.000	-	-		otm42361
orthoMCL	1	0.900	-	-		OOG6_102607
Panther	1	1.100	-	-	O	PTHR45885
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1623
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900